DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns4 and Gnl1

DIOPT Version :9

Sequence 1:	NP_610055.1	Gene:	Ns4 / 35338	FlyBaseID:	FBgn0032882	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_036016217.1	Gene:	Gnl1 / 14670	MGIID:	95764	Length:	730	Species:	Mus musculus

Alignment Length:	600	Identity:	255/600 - (42%)
Similarity:	341/600 - (56%)	Gaps:	61/600 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KDQMLQKRNTKGPPKYLRSTQESYEDSD-VPETTRKLMEQPFARGGNRNKNVNRYNLQFYQEGKK 79
            :|.:....|::...:..|..|....|.: |....|:|.:||....|.|..:.|||.|.|.::.::
Mouse   150 QDGLRSSSNSRSGSRERREEQTDTSDGESVTHHIRRLNQQPSQGLGPRGYDPNRYRLHFERDSRE 214

  Fly    80 ELEQMKQEGFKPFEKLSPAQREV---DDR--YFAG--CDFPVRPPWTLTESKEELDRTENRYFKE 137
            |:|:.|:...:  :.|.|...||   |.|  |..|  .|||.||||:...|||:|...|.|.|:|
Mouse   215 EVERRKRAARE--QVLQPVSAEVLELDIREVYQPGSVLDFPRRPPWSYEMSKEQLMSQEERSFQE 277

  Fly   138 YVDELQKKQRAGDSKELSLFELNLETWRQLWRVLEFSDILLIIVDVRYATLMFPPSLYDYIINTL 202
            |   |.|...|..|::||.||.|||||||||||||.|||:|:|.|:|:..:.|||:||:|:...|
Mouse   278 Y---LGKIHGAYTSEKLSYFEHNLETWRQLWRVLEMSDIVLLITDIRHPVVNFPPALYEYVTGEL 339

  Fly   203 KKHAIVVFNKVDLVEPHAVVAWRQYFRDRYPQLPVVLFASFLPRS-----------RKGSQRGPQ 256
            ....::|.|||||..|..||||:.||...||||.:|||.|| ||.           :|..:|| :
Mouse   340 GLALVLVLNKVDLAPPALVVAWKHYFHQCYPQLHIVLFTSF-PRDTRTPQEPGGVLKKNRRRG-K 402

  Fly   257 AHRRSMEGVYNIYKECQRYVQGEVDLTTWEQKIREDMRSDQLDIL------DEISTAVEGELKIS 315
            ...|:: |...:.:.|:....|:|||::|.:||..|:.......:      :|...||..|....
Mouse   403 GWTRAL-GPEQLLRACEAITVGKVDLSSWREKIARDVAGASWGNVSGEEEEEEDGPAVLVEQLTD 466

  Fly   316 SSIDTTPHEHVKYHSGVLTIGCIGFPNVGKSSLINALKGRKVVSVSRTPGHTKHFQTIFLTPLVR 380
            |:::.|.....:|..||:|||||||||||||||||.|.||||||||||||||::|||.||||.|:
Mouse   467 SAMEPTGPSRERYKDGVVTIGCIGFPNVGKSSLINGLVGRKVVSVSRTPGHTRYFQTYFLTPSVK 531

  Fly   381 LCDCPGLVFPSSTPKSLQVLLGSFPISQLAVPYRSLKFLGEHLNLPQLLRLHLPEDYD-----EW 440
            |||||||:|||..|:.||||.|.:||:|:..||.|:.:|...:.:..||.|..||..|     .|
Mouse   532 LCDCPGLIFPSLLPRQLQVLAGIYPIAQIQEPYTSVGYLASRIPVQALLHLRHPEAEDPSAEHPW 596

  Fly   441 SAVAISDAWAYKRGFLTAKAARPDRYRAANHILRMCLAGQQMLVLQFYPPGFEERREHWLQHPDV 505
            .|..|.:|||.|||:.||||||.|.|||||.:||:.:.|:  |.|.|||||:.|:|..|..||:.
Mouse   597 CAWDICEAWAEKRGYKTAKAARNDVYRAANSLLRLAVDGR--LSLCFYPPGYSEQRGTWESHPET 659

  Fly   506 GEVKKYQ-QV-ELDEPESETNGDTSSVCSDTADSEDEDEDSSNDETNADEEECGIREDAPRS--- 565
            .|:...| :| ...:.|.|...:.||.|          |:...::.:||||..| .||.|.|
Mouse   660 AELVLSQGRVGPAGDEEEEEEEELSSSC----------EEEGEEDRDADEEGEG-DEDTPTSDPG 713

  Fly   566 -----RNVFALLEDD 575
                 ||.:|||.:|
Mouse   714 SCLTARNPYALLGED 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns4	NP_610055.1	HSR1_MMR1	163..390	CDD:206750	118/243 (49%)
Ns4	NP_610055.1	GTPase_YlqF	165..474	CDD:274669	159/330 (48%)
Gnl1	XP_036016217.1	RbgA	293..637	CDD:224083	169/348 (49%)
Gnl1	XP_036016217.1	HSR1_MMR1	300..541	CDD:206750	118/243 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837066
Domainoid	1	1.000	195	1.000	Domainoid score	I3161
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3862
Inparanoid	1	1.050	409	1.000	Inparanoid score	I1853
Isobase	1	0.950	-	0	Normalized mean entropy	S2808
OMA	1	1.010	-	-		QHG55394
OrthoDB	1	1.010	-	-		D206558at33208
OrthoFinder	1	1.000	-	-		FOG0008221
OrthoInspector	1	1.000	-	-		oto93108
orthoMCL	1	0.900	-	-		OOG6_104554
Panther	1	1.100	-	-	LDO	PTHR45709
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5461
SonicParanoid	1	1.000	-	-		X6193
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750