Protein Alignment Ns4 and Ns4

DIOPT Version :10

• Sequence 1: NP_610055.1
• Gene: Ns4 / 35338
• FlyBaseID: FBgn0032882
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_317131.5
• Gene: Ns4 / 1277654
• VectorBaseID: AGAMI1_014625
• Length: 587
• Species: Anopheles gambiae
• Alignment Length: 596
• Identity: 300/596 - (50%)
• Similarity: 374/596 - (62%)
• Gaps: 37/596 - (6%)

  Fly     1 MPQQRRKVAFSGKKKKDQMLQKRNTKGPPKY-----LRSTQES--YEDSDVPET----TRKLMEQ 54
            |||.|||||||||:||.|:|.|:..|....:     |:..:.|  .||||:|.|    ..|:..|
Mosquito     1 MPQGRRKVAFSGKQKKQQLLAKKQAKSSTSHNLIRNLKDEESSDISEDSDMPRTFGQNIEKINLQ 65

  Fly    55 PFARGGNRNKNVNRYNLQFYQEGKKELEQMKQEGFKPFEKLSPAQREVDDRYFAGCDFPVRPPWT 119
            |..   :.....|||.|||::|..|||.:||:|..|.....|..:.|:.|.||...|||.||.||
Mosquito    66 PLK---DPRSKTNRYVLQFHRETAKELREMKEEARKGLVYRSEQEMELGDNYFQQYDFPTRPKWT 127

  Fly   120 LTESKEELDRTENRYFKEYVDELQKKQRAGDSKELSLFELNLETWRQLWRVLEFSDILLIIVDVR 184
            ...|||:||..|||||.:||.:|: |....|.|.||..|||||||||||||||.|||:|||||.|
Mosquito   128 YEMSKEQLDGNENRYFFKYVTKLE-KDHYDDMKSLSFCELNLETWRQLWRVLELSDIVLIIVDAR 191

  Fly   185 YATLMFPPSLYDYIINTLKKHAIVVFNKVDLVEPHAVVAWRQYFRDRYPQLPVVLFASFLPRSRK 249
            :.||||||:||.|:...|.|..::|.||:||||..||:||::||..:||.:.||||.|:...:.:
Mosquito   192 FPTLMFPPALYKYVTEELGKGMMLVINKIDLVEAEAVLAWKRYFEQKYPHIHVVLFTSYPSYNLR 256

  Fly   250 GSQR---GPQAHRR------SMEGVYNIYKECQRYVQGEVDLTTWEQKIREDMRSDQLDILDEIS 305
            |.|.   |.:..||      :.||...||..|.:||..||||.:|||||.|: |:..:::..:..
Mosquito   257 GKQESKYGLKIRRRRGRMRMAAEGAQQIYDICHKYVGDEVDLGSWEQKILEE-RNAPMEVDGDED 320

  Fly   306 TAVEGELKISSSIDTTPHEHVKYHSGVLTIGCIGFPNVGKSSLINALKGRKVVSVSRTPGHTKHF 370
            ..:..|.......|....||||:.:|||||||:|:||||||||:||:.|||||||||||||||||
Mosquito   321 KKLVSERTHEEEKDFAFEEHVKFKNGVLTIGCVGYPNVGKSSLLNAVMGRKVVSVSRTPGHTKHF 385

  Fly   371 QTIFLTPLVRLCDCPGLVFPSSTPKSLQVLLGSFPISQLAVPYRSLKFLGEHLNLPQLLRLHLPE 435
            ||||||..||||||||||||||||:.||||:||:||:||..||.|::||.|.|:|.:||.|..||
Mosquito   386 QTIFLTNTVRLCDCPGLVFPSSTPRRLQVLMGSYPIAQLREPYASIRFLAERLDLVRLLSLKHPE 450

  Fly   436 -DYDEWSAVAISDAWAYKRGFLTAKAARPDRYRAANHILRMCLAGQQMLVLQFYPPGFEERREHW 499
             |.|||||:.|.||||.|||||||||||||.|||||.||||.|.|:  :.|...|.|:...:|..
Mosquito   451 SDNDEWSAIDICDAWAIKRGFLTAKAARPDTYRAANSILRMALDGK--ITLSLKPIGYHLEKEKL 513

  Fly   500 LQHPDVGEVKKYQQVELDEPESETNGDTSSVCSDTADSEDEDEDSSNDETNADEEECGIREDAP- 563
            ...|.:..||:.|.:    .|::.|.|.....||| |:||. ..:|||..|.::|:.......|
Mosquito   514 ATDPGLARVKEIQAI----VENDGNDDEDDCFSDT-DTEDM-AGASNDGDNEEDEDPNSTMSPPA 572

  Fly   564 --RSRNVFALL 572
              .|.|.|.||
Mosquito   573 GSSSANPFDLL 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns4	NP_610055.1	HSR1_MMR1	163..390	CDD:206750	130/235 (55%)
		RbgA	204..474	CDD:440775	160/279 (57%)
Ns4	XP_317131.5	None