DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns4 and lsg1

DIOPT Version :9

Sequence 1:	NP_610055.1	Gene:	Ns4 / 35338	FlyBaseID:	FBgn0032882	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_002937880.1	Gene:	lsg1 / 100145528	XenbaseID:	XB-GENE-990730	Length:	637	Species:	Xenopus tropicalis

Alignment Length:	601	Identity:	171/601 - (28%)
Similarity:	270/601 - (44%)	Gaps:	131/601 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GKKK----------KDQMLQKRNTKGPPKYLRSTQ--ESY-----------EDSDVPE--TTRKL 51
            ||||          |::...:|..:....:|.:::  :.|           |.|.:.:  .|.:|
Frog     2 GKKKATCGLGRALIKERAQSQRGLRAKDSWLHTSELNDGYDWGRLNLQSVTEQSSIDDFLATAEL 66

  Fly    52 MEQPFARGGNRNKNVNRYNLQFYQ-EGKKELEQMKQEGFKPFEKLSPAQREVDDRYFAGCDFPVR 115
            ....|.        ..:.|::|.. |.:.||  :..|..|...||     :.:::.|. | .|.|
Frog    67 AGTEFV--------AEKLNIKFVSAEARTEL--LTSEETKRIHKL-----QEENKQFL-C-IPRR 114

  Fly   116 PPWTLTESKEELDRTENRYFKEYVDELQKKQRAGDSKELSL--FELNLETWRQLWRVLEFSDILL 178
            |.|..:.|.|.|..||...|.::..:|.:.:   :.|:|.|  ||.||:.|||||||:|.||:::
Frog   115 PHWDESTSAEVLRETERETFLQWRRQLAQLE---EEKKLILTPFERNLDFWRQLWRVIERSDVVV 176

  Fly   179 IIVDVRYATLMFPPSLYDYIINTLK-KHAIVVFNKVDLVEPHAVVAWRQYFRDRYPQLPVVLFAS 242
            .|||.|...|.....|..|:....| |..|::.||.||:......:|.::|.....:   |:|.|
Frog   177 QIVDARNPLLFRCQDLECYVKEIDKDKENIILINKADLLTAQQRQSWAEFFEKEGVK---VVFWS 238

  Fly   243 FLPRSRKGSQRGPQAHR---RSMEGVYNIYKECQ---RYVQGE---------VDLTTWE------ 286
            .|...::.:..|...|.   :..||.:...:|.:   ...|||         :|..|.|
Frog   239 ALAEGQRLTAEGKVEHLDEIKENEGDFTDEEESESESEETQGENLHTRGNSGLDNDTSEEYEDCE 303

  Fly   287 -----QKIREDMRSDQLDILDEISTAVEGELKISS-----------SIDTTPHEHVKYHSGVLTI 335
                 |...||...|.:...|:..|...|:..|::           .|..:.|...:...|.:|:
Frog   304 EDEGWQTCSEDADDDDIISQDKDHTRTVGDKLITNQSHLVERDELLEIFKSVHAGQRIKEGQITV 368

  Fly   336 GCIGFPNVGKSSLINALKGRKVVSVSRTPGHTKHFQTIFLTPLVRLCDCPGLVFPS--STPKSLQ 398
            |.:|:|||||||.||.:.|.|.||||.||||||||||:::...:.||||||||.||  || |:..
Frog   369 GLVGYPNVGKSSTINTILGNKKVSVSATPGHTKHFQTLYVEQELCLCDCPGLVMPSFVST-KAEM 432

  Fly   399 VLLGSFPISQL------------AVPYRSLKFL-GEHLNLPQLLRLHLPEDYDEWSAVAISD--- 447
            :..|..||.|:            .:|..:|:.: |.::..|:       ||.|:.......:
Frog   433 ICSGILPIDQMRDHVPPISLIAQRIPRHALETIYGINIIRPR-------EDEDQDRPPTSEEFLC 490

  Fly   448 AWAYKRGFLTAKAARPDRYRAANHILRMCLAGQQMLVLQFYPPGFE--ERREHWLQHPD------ 504
            |:.|.|||:||. .:||:.|:|.::|:..::|:  |:....|||.|  |.:..::::.:
Frog   491 AYGYMRGFMTAH-GQPDQPRSARYVLKDYVSGK--LLYCHPPPGIEPAEFQPQFVKYEEKKGLKI 552

  Fly   505 VGEV-----KKYQQVE 515
            .||.     ||.:|:|
Frog   553 SGESQAHRGKKTRQIE 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns4	NP_610055.1	HSR1_MMR1	163..390	CDD:206750	88/264 (33%)
Ns4	NP_610055.1	GTPase_YlqF	165..474	CDD:274669	114/364 (31%)
lsg1	XP_002937880.1	RbgA	136..547	CDD:224083	131/427 (31%)
		HSR1_MMR1	161..423	CDD:206750	88/264 (33%)
		P-loop_NTPase	345..>387	CDD:304359	15/41 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55394
OrthoDB	1	1.010	-	-		D206558at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930