DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Amacr and Amacr

DIOPT Version :9

Sequence 1:	NP_001260638.1	Gene:	Amacr / 35337	FlyBaseID:	FBgn0032881	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_032563.2	Gene:	Amacr / 17117	MGIID:	1098273	Length:	381	Species:	Mus musculus

Alignment Length:	344	Identity:	182/344 - (52%)
Similarity:	238/344 - (69%)	Gaps:	12/344 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLKGIRVLEFVGLAPGPFCGKILTDFGATVTRIDKVMENPLDVLQQGKRTLCLDLKNPKGQQAV 65
            |.|:|:||:|..|||||||||.:|.||||.|.|::::.....:.|.:|||:|.||||..:|...:
Mouse     1 MVLRGVRVVELAGLAPGPFCGMVLADFGAEVVRVNRLGSTGENFLARGKRSLALDLKRSQGVTVL 65

  Fly    66 QRLVKKCDVLIEPFRPGVMEKLNLGPTDLCTANPRLIYARLTGFGQHGRLAQRAGHDINYAALSG 130
            :|:..:.|||:||||.||||||.|||..|...||:||||||:||||.|..::.|||||||.||||
Mouse    66 RRMCARADVLLEPFRCGVMEKLQLGPETLLQDNPKLIYARLSGFGQSGIFSKVAGHDINYLALSG 130

  Fly   131 VLSMLGRRHEKVTAPINILADFAGGSLMCALGICLALLERHRSGKGQVVDASMVEGAAYVASWLF 195
            |||.:||..|....|:|:||||.||.|||.|||.|||.||.|||:|||:|:|||||.||::|:|:
Mouse   131 VLSKIGRSGENPYPPLNLLADFGGGGLMCTLGIVLALFERTRSGRGQVIDSSMVEGTAYLSSFLW 195

  Fly   196 MSRNLVIWGRERGDNLVDGGSFFYDTYETKDGRYMSVGALEPQFFEMLKQRL-----ELPEDVSQ 255
            .::.:.:|.:.||.|::|||:.||.||:|.||.:|:|||:||||:.:|.:.|     |||   ||
Mouse   196 KTQPMGLWKQPRGQNILDGGAPFYTTYKTADGEFMAVGAIEPQFYALLLKGLGLESEELP---SQ 257

  Fly   256 FGEEHQVRGRKLLTEAFLSKTQAEWSQIFEDVDACVYPVLDYREVHRHDHNIQRNSFEVT--EDT 318
            .........:|...:.|..||:|||.|||:..||||.|||.:.|...|.||.:|.|| :|  |..
Mouse   258 MSSADWPEMKKKFADVFAKKTKAEWCQIFDGTDACVTPVLTFEEALHHQHNRERASF-ITDGEQL 321

  Fly   319 ATPRPAPVLSRTPGKLPKA 337
            .:|||||:|||||. :|.|
Mouse   322 PSPRPAPLLSRTPA-VPSA 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Amacr	NP_001260638.1	CaiB	2..365	CDD:224717	181/343 (53%)
Amacr	NP_032563.2	CaiB	3..372	CDD:224717	181/342 (53%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:O06543	54..57		2/2 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:O06543	120..125		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..344		13/22 (59%)
		Microbody targeting signal. /evidence=ECO:0000250\|UniProtKB:Q9UHK6	379..381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842631
Domainoid	1	1.000	351	1.000	Domainoid score	I1015
eggNOG	1	0.900	-	-		E1_COG1804
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7410
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2250
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58683
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006141
OrthoInspector	1	1.000	-	-		oto93401
orthoMCL	1	0.900	-	-		OOG6_104022
Panther	1	1.100	-	-	LDO	PTHR22923
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3686
SonicParanoid	1	1.000	-	-		X4431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790