DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and KAP123

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_011035.1	Gene:	KAP123 / 856846	SGDID:	S000000912	Length:	1113	Species:	Saccharomyces cerevisiae

Alignment Length:	964	Identity:	193/964 - (20%)
Similarity:	359/964 - (37%)	Gaps:	246/964 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QLIAILEKTVSPDKNELLSAKNFLE-----QAAASNLPEFLKALSEILVNTANSAVARMAAGLQL 67
            |.::.||:|:    :.:.|.....|     |......|..|.||..||.|.::.::.:: ||::.
Yeast     4 QFLSQLEQTL----HAITSGVGLKEATKTLQTQFYTQPTTLPALIHILQNGSDDSLKQL-AGVEA 63

  Fly    68 KNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGT---ENTRPSCAAQCVAYVAVIELPI 129
            :. |.||          .|:......|..||.::|....:   ||.|.| .|:.:|.:...||..
Yeast    64 RK-LVSK----------HWNAIDESTRASIKTSLLQTAFSEPKENVRHS-NARVIASIGTEELDG 116

  Fly   130 NRWPMLIQTLVNKVVSEGSSEMHRESALEAIGYICQD-------------------------IRF 169
            |:||.|:..|:.  .:.|.....|::|:..:..:.:|                         :..
Yeast   117 NKWPDLVPNLIQ--TASGEDVQTRQTAIFILFSLLEDFTSSLSGHIDDFLALFSQTINDPSSLEI 179

  Fly   170 GVMENQSNDVLTAIIHGMRKVEPSNHVRLAAT---------------TALHNSLEFTKSN----F 215
            ..:..|:.:.::|:|.....:.|....:.||:               ..::..|.|...|    .
Yeast   180 RSLSAQALNHVSALIEEQETINPVQAQKFAASIPSVVNVLDAVIKADDTMNAKLIFNCLNDFLLL 244

  Fly   216 EKDMERNFIMEVVCEATQCQ-----DSQICVAALQCLVKIMTLYYQYMEPYMAQA-LFP-ITLAA 273
            :..:..|||::::..:.|..     |..:.|.|||.::..::    |.:..::|: |.| ||:||
Yeast   245 DSQLTGNFIVDLIKLSLQIAVNSEIDEDVRVFALQFIISSLS----YRKSKVSQSKLGPEITVAA 305

  Fly   274 MKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVEKLTK 338
            :|                |..||||:..|.....:.|...:......|...|.|.:..|
Yeast   306 LK----------------VACEEIDVDDELNNEDETGENEENTPSSSAIRLLAFASSEL------ 348

  Fly   339 QDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGL 403
                      .|::.|||            ||.|    |...::|.|...|.|.::.....:.|.
Yeast   349 ----------PPSQVASV------------IVEH----IPAMLQSANVFERRAILLAISVAVTGS 387

  Fly   404 ETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRI-CDIIPEAA-INETYLQTLLECFVKSL 466
            ....|... ::.:|..|..:.|:..||:........:: .|:..|.| .:|.||..::: .:.|.
Yeast   388 PDYILSQF-DKIIPATINGLKDTEPIVKLAALKCIHQLTTDLQDEVAKFHEEYLPLIID-IIDSA 450

  Fly   467 KSEPRVAANVCWAFIGLSDAAWEAAVTNDG--ETPETYALSPYFEYIITQL---LETTDRSDGAQ 526
            |:      .|.:.:         |.|..||  |.....|::.|.:.::.:|   ||:.:.|
Yeast   451 KN------IVIYNY---------ATVALDGLLEFIAYDAIAKYLDPLMNKLFYMLESNESS---- 496

  Fly   527 ANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCA 591
             .||||...|: .....:....::...:|::..||:.   :|..:||...|:    :|:: |...
Yeast   497 -KLRCAVVSAI-GSAAFAAGSAFIPYFKTSVHYLEKF---IQNCSQIEGMSE----DDIE-LRAN 551

  Fly   592 TLQSV---LRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYM 653
            |.:::   .|.|......:.::.::.:......:.:.:   ::|..:..::.|.::.|..||
Yeast   552 TFENISTMARAVRSDAFAEFAEPLVNSAYEAIKTDSAR---LRESGYAFIANLAKVYGENFA--- 610

  Fly   654 PAFKDFLVMGLKNFQ--EYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVK 716
            |..|..|....|..:  |||     ....||    .:||.....:.....|.|..|..|.....|
Yeast   611 PFLKTILPEIFKTLELDEYQ-----FNFDGD----AEDLAAFADSANEEELQNKFTVNTGISYEK 666

  Fly   717 PQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINE---LRESILEAYTGI 778
            ....:|..::||....|||||:...|.:|               ||.::|   |||:.|.....:
Yeast   667 EVASAALSELALGTKEHFLPYVEQSLKVL---------------NEQVDESYGLRETALNTIWNV 716

  Fly   779 IQGL------------KGVDQTAHTDVMHMEPHLMHIISFIK--RIAQEGDVSD----SMLASAA 825
            ::.:            ||:..:::.:.        .:::.|:  |....|::||    ||:.:..
Yeast   717 VKSVLLASKVEPESYPKGIPASSYVNA--------DVLAVIQAARETSMGNLSDEFETSMVITVM 773

  Fly   826 GFIGDLCTSFGPRLYPLLDDAIITQFLAEGKRSKAQRTKMLCTWAVKEIKKINT 879
            ....::...||         |||  .:..|..|..:   .||...:..:|..:|
Yeast   774 EDFANMIKQFG---------AII--IMDNGDSSMLE---ALCMQVLSVLKGTHT 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	187/950 (20%)
		IBN_N	27..107	CDD:281761	19/84 (23%)
		HEAT repeat	136..162	CDD:293787	4/25 (16%)
		HEAT repeat	179..209	CDD:293787	5/44 (11%)
		HEAT repeat	223..255	CDD:293787	8/36 (22%)
		HEAT repeat	264..291	CDD:293787	8/28 (29%)
		HEAT repeat	330..360	CDD:293787	5/29 (17%)
		HEAT repeat	373..401	CDD:293787	5/27 (19%)
		HEAT_EZ	386..441	CDD:290247	9/54 (17%)
		HEAT repeat	414..444	CDD:293787	5/30 (17%)
		HEAT repeat	457..482	CDD:293787	3/24 (13%)
		HEAT repeat	508..540	CDD:293787	9/34 (26%)
KAP123	NP_011035.1	IBN_N	25..92	CDD:197981	18/78 (23%)
		HEAT repeat	40..65	CDD:293787	8/25 (32%)
		HEAT repeat	77..111	CDD:293787	10/34 (29%)
		HEAT repeat	121..151	CDD:293787	5/31 (16%)
		HEAT repeat	162..189	CDD:293787	1/26 (4%)
		HEAT repeat	352..385	CDD:293787	11/48 (23%)
		HEAT repeat	397..427	CDD:293787	5/29 (17%)
		HEAT repeat	438..468	CDD:293787	9/45 (20%)
		HEAT repeat	479..506	CDD:293787	8/31 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910