DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and KAP104

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_009573.1	Gene:	KAP104 / 852305	SGDID:	S000000221	Length:	918	Species:	Saccharomyces cerevisiae

Alignment Length:	909	Identity:	175/909 - (19%)
Similarity:	310/909 - (34%)	Gaps:	266/909 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DIAMQLIAILEKTVSPD----KNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVA----- 59
            |..:||..:|:..:||:    .|.:.:.:||..|      ||||..|..||:...:..|.
Yeast    10 DYVLQLATLLQNCMSPNPEIRNNAMEAMENFQLQ------PEFLNYLCYILIEGESDDVLKQHYS 68

  Fly    60 -------RMAAGLQLKNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTEN-------- 109
                   |..||:.|||.:...:..:.....|..:         :|:||:..|...|
Yeast    69 LQDLQNNRATAGMLLKNSMLGGNNLIKSNSHDLGY---------VKSNIIHGLYNSNNNLVSNVT 124

  Fly   110 -----------------------------------TRPSCAA-----QCVAYVAVIELPINRWPM 134
                                               ..||..|     :..|....:|...|..||
Yeast   125 GIVITTLFSTYYRQHRDDPTGLQMLYQLLELTSNGNEPSIKALSKIMEDSAQFFQLEWSGNTKPM 189

  Fly   135 --LIQTLVNKVVSEGSSEMHRESALEAIGYICQ--------------DIRFGVMENQSNDVLTAI 183
              |:.:....:.:...|.:.|..:::.|..:..              :|.|.:.:|..||:
Yeast   190 EALLDSFFRFISNPNFSPVIRSESVKCINTVIPLQTQSFIVRLDKFLEIIFQLAQNDENDL---- 250

  Fly   184 IHGMRKVEPSNHVRLAATTALHNSLEFTKSNFEKDMER--NFIMEVVCEATQCQDSQICVAALQC 246
                        ||.....:....|||........::.  .|::.::   |...:.::.:.|.:.
Yeast   251 ------------VRAQICISFSFLLEFRPDKLVSHLDGIVQFMLHLI---TTVNEEKVAIEACEF 300

  Fly   247 LVKIMT---LYYQYMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATD 308
            |....|   :....::||: :.:.||.|:.|..:.:::.|  :|     ...:.|..:|.::...
Yeast   301 LHAFATSPNIPEHILQPYV-KDIVPILLSKMVYNEESIVL--LE-----ASNDDDAFLEDKDEDI 357

  Fly   309 QGRAPQRVSKHYARGALQFLTPVLVEKLTKQDECDDED-----TWSPAKAASVCLMVLATCCEDE 368
            :..||:.|.|..|.....     ..:.....|:.||||     .|:..|.::..|.|:......:
Yeast   358 KPIAPRIVKKKEAGNGED-----ADDNEDDDDDDDDEDGDVDTQWNLRKCSAATLDVMTNILPHQ 417

  Fly   369 IVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNG---LETNTLKPLVEQAMPTLIRLMYDSSVIV 430
            ::....||::|::.|..|..|:|.::..|::..|   ...:.|..|:    |.|:..:.|....|
Yeast   418 VMDIAFPFLREHLGSDRWFIREATILALGAMAEGGMKYFNDGLPALI----PFLVEQLNDKWAPV 478

  Fly   431 RDTIAWTFGRICDIIPEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTN- 494
            |....||..|....|.:.  :..:|..:||..:.:|..:.:              ...|||:::
Yeast   479 RKMTCWTLSRFSPWILQD--HTEFLIPVLEPIINTLMDKKK--------------DVQEAAISSV 527

  Fly   495 -------DGETPETYALSPYFEYIITQLLETTDRSDGAQANLRCAAYQ------ALMDMIKNSPL 546
                   |.|..||...|        |||.:.|         :|..|.      .|.|.|.....
Yeast   528 AVFIENADSELVETLFYS--------QLLTSFD---------KCLKYYKKKNLIILYDAIGRFAE 575

  Fly   547 DCYLVVQRTTL-VILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVLRKVHEQDAPQISD 610
            .|.|  ..|.: :||..|.:    :..:.:.||:..:..|:.|.|.             |..:.:
Yeast   576 KCAL--DETAMQIILPPLIE----KWALLSDSDKELWPLLECLSCV-------------ASSLGE 621

  Fly   611 AIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVEL--LGAQFAKYMPAFKDFLVMGLKNFQEYQVC 673
            ..|.....::|           .||..:...|||  ...|....:...|||::..|....
Yeast   622 RFMPMAPEVYN-----------RAFRILCHCVELEAKSHQDPTIVVPEKDFIITSLDLID----- 670

  Fly   674 CAAVGLTGDIFRALKDLMVPYSNEIMTVL---INNLTEPTIHRTVKPQVLSAFGDIA------LS 729
                ||...:....:||:.|...:.:|:|   :..|.:| :|. |:....:..|||.      |.
Yeast   671 ----GLVQGLGAHSQDLLFPQGTKDLTILKIMLECLQDP-VHE-VRQSCFALLGDIVYFFNSELV 729

  Fly   730 IGN--HFLPYLSMVLDMLRVASNLQTD---------------ANNFDMNEYINELRESILEAYT 776
            |||  .||..:.     ..:..|..:|               :...|:|.||.::...||:.:|
Yeast   730 IGNLEDFLKLIG-----TEIMHNDDSDGTPAVINAIWALGLISERIDLNTYIIDMSRIILDLFT 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	171/896 (19%)
		IBN_N	27..107	CDD:281761	22/91 (24%)
		HEAT repeat	136..162	CDD:293787	3/25 (12%)
		HEAT repeat	179..209	CDD:293787	2/29 (7%)
		HEAT repeat	223..255	CDD:293787	5/34 (15%)
		HEAT repeat	264..291	CDD:293787	6/26 (23%)
		HEAT repeat	330..360	CDD:293787	8/34 (24%)
		HEAT repeat	373..401	CDD:293787	8/27 (30%)
		HEAT_EZ	386..441	CDD:290247	14/57 (25%)
		HEAT repeat	414..444	CDD:293787	8/29 (28%)
		HEAT repeat	457..482	CDD:293787	3/24 (13%)
		HEAT repeat	508..540	CDD:293787	7/37 (19%)
KAP104	NP_009573.1	HEAT repeat	191..225	CDD:293787	4/33 (12%)
		HEAT repeat	234..261	CDD:293787	7/42 (17%)
		HEAT repeat	272..301	CDD:293787	3/31 (10%)
		HEAT repeat	422..450	CDD:293787	8/27 (30%)
		HEAT_2	424..528	CDD:290374	27/123 (22%)
		HEAT_EZ	435..489	CDD:290247	14/57 (25%)
		HEAT repeat	462..492	CDD:293787	9/33 (27%)
		HEAT repeat	500..529	CDD:293787	7/42 (17%)
		HEAT repeat	546..572	CDD:293787	9/34 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910