DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and KAP95

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_013451.1	Gene:	KAP95 / 851061	SGDID:	S000004339	Length:	861	Species:	Saccharomyces cerevisiae

Alignment Length:	898	Identity:	299/898 - (33%)
Similarity:	483/898 - (53%)	Gaps:	66/898 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TSDIAMQLIAILEKTV-SPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGL 65
            |::.|.    :||.:: |||:|..|:::..|::.:..|..:|....|::|::.......|:.|.|
Yeast     3 TAEFAQ----LLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAAL 63

  Fly    66 QLKNHLTSKDEKVSQQYQDRW-HQFPSEIRELIKNNILAALGTENTR-PSCAAQCVAYVAVIELP 128
            .|||.|.|||...:||:..|| .|...|.:..||.|.|.||.:...| .:.|||.:|.:|.||||
Yeast    64 TLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADIELP 128

  Fly   129 INRWPMLIQTLVNKVVSEGSSEMHRESALEAIGYICQ--DIRFGVMENQSNDVLTAIIHGMRKVE 191
            ...||.|::.:|:...:|....:.|.|.| |:||:|:  |.:...:.:.||::|.||:.|.:..|
Yeast   129 HGAWPELMKIMVDNTGAEQPENVKRASLL-ALGYMCESADPQSQALVSSSNNILIAIVQGAQSTE 192

  Fly   192 PSNHVRLAATTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQ 256
            .|..|||||..||.:||.|.|:|.|::.|||::|:|||||||.:|.::..||..||.|||:|||.
Yeast   193 TSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSLYYT 257

  Fly   257 YMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQR--VSKH 319
            :|:|||.|||:.:|:|.|||.||.||...:||||.:|:||||:|.|      ..:.||.  .|.:
Yeast   258 FMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYE------LAQFPQSPLQSYN 316

  Fly   320 YARGALQFLTPVLVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESP 384
            :|..:::.:.|.|:..||:|:|..::|.|:.:.:|..||.:.|..|.:.|:..||.|:::||.:.
Yeast   317 FALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHILEPVLEFVEQNITAD 381

  Fly   385 NWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAA 449
            |||.|:||||.|||:::|.:.......|.||:|:::.||.|.|:.|::|.||..|||.|.:.|:.
Yeast   382 NWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESI 446

  Fly   450 INETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEY---I 511
            ..:.:|..:::..:..|:..|:||.|..|..|.|.:...||       ||     ||.:.:   :
Yeast   447 DPQQHLPGVVQACLIGLQDHPKVATNCSWTIINLVEQLAEA-------TP-----SPIYNFYPAL 499

  Fly   512 ITQLLETTDRSDGAQANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNH 576
            :..|:...:|.|. :.|.|.:|:.||..|::.:...........:..::::|.|.|.::......
Yeast   500 VDGLIGAANRIDN-EFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTL 563

  Fly   577 SDRHQFNDLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTL 641
            .|.....:|||.:...|.:|:||......| ::|.:|.....:....  .|..::::.|.|:|.|
Yeast   564 EDAQSLQELQSNILTVLAAVIRKSPSSVEP-VADMLMGLFFRLLEKK--DSAFIEDDVFYAISAL 625

  Fly   642 VELLGAQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNL 706
            ...||..|.||:..|..:|:..| |..:..|...|||...||..:|::....||:.:|.||...:
Yeast   626 AASLGKGFEKYLETFSPYLLKAL-NQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMI 689

  Fly   707 TEPTIHRTVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESI 771
            :.|...|.:||.|||.|||||.:||..|:|||:.::.:...|.|.:.:....:..:|..::.|::
Yeast   690 SNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAV 754

  Fly   772 LEAYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGDV--SDSMLASAAGFIGDLCTS 834
            |:||.||:.||       |.....:.|::..|..||.::|::..:  .|:...:|.|.|||:...
Yeast   755 LDAYVGIVAGL-------HDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAM 812

  Fly   835 FGPRLYPLLDDAIITQFLAEG------KRSK-----AQRTKMLCTWAVKEIKK 876
            |        .|..|.||..:.      ||::     :|.||....||.::.|:
Yeast   813 F--------PDGSIKQFYGQDWVIDYIKRTRSGQLFSQATKDTARWAREQQKR 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	294/881 (33%)
		IBN_N	27..107	CDD:281761	27/80 (34%)
		HEAT repeat	136..162	CDD:293787	6/25 (24%)
		HEAT repeat	179..209	CDD:293787	14/29 (48%)
		HEAT repeat	223..255	CDD:293787	17/31 (55%)
		HEAT repeat	264..291	CDD:293787	15/26 (58%)
		HEAT repeat	330..360	CDD:293787	11/29 (38%)
		HEAT repeat	373..401	CDD:293787	16/27 (59%)
		HEAT_EZ	386..441	CDD:290247	24/54 (44%)
		HEAT repeat	414..444	CDD:293787	14/29 (48%)
		HEAT repeat	457..482	CDD:293787	6/24 (25%)
		HEAT repeat	508..540	CDD:293787	8/34 (24%)
KAP95	NP_013451.1	KAP95	1..861	CDD:227540	299/898 (33%)
		HEAT repeat	135..164	CDD:293787	9/29 (31%)
		HEAT repeat	180..215	CDD:293787	17/34 (50%)
		HEAT repeat	224..253	CDD:293787	15/28 (54%)
		HEAT repeat	264..293	CDD:293787	16/28 (57%)
		HEAT repeat	326..357	CDD:293787	11/30 (37%)
		HEAT repeat	370..398	CDD:293787	16/27 (59%)
		HEAT repeat	411..441	CDD:293787	14/29 (48%)
		HEAT repeat	454..479	CDD:293787	6/24 (25%)
		HEAT repeat	496..527	CDD:293787	8/31 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346425
Domainoid	1	1.000	217	1.000	Domainoid score	I472
eggNOG	1	0.900	-	-		E1_COG5215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1707
Inparanoid	1	1.050	467	1.000	Inparanoid score	I232
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S954
OMA	1	1.010	-	-		QHG56400
OrthoFinder	1	1.000	-	-		FOG0003173
OrthoInspector	1	1.000	-	-		oto99493
orthoMCL	1	0.900	-	-		OOG6_101642
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R600
SonicParanoid	1	1.000	-	-		X2136
TreeFam	1	0.960	-	-
	16	15.740