DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and Gcn1

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_001162135.1	Gene:	Gcn1 / 690632	RGDID:	1593434	Length:	2671	Species:	Rattus norvegicus

Alignment Length:	1066	Identity:	202/1066 - (18%)
Similarity:	354/1066 - (33%)	Gaps:	355/1066 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIAILEK---TVSPDKNELLSAKNF-LEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKN 69
            |:|.||:   .......|||.|..: ..:..:|.||..:..|:|:
  Rat  1502 LLAALEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEV-------------------- 1546

  Fly    70 HLTSKDEKVSQQYQDRWHQFPSEIRE----LIKNNILAALGTENTRPSCAAQ-CV------AYVA 123
             ||....||.:..|....|..|.||.    .|...:|.||    |.||...| |:      .:|.
  Rat  1547 -LTDSHVKVQKAGQQALRQIGSVIRNPEILAIAPVLLDAL----TDPSRKTQKCLQTLLDTKFVH 1606

  Fly   124 VIELPINRWPMLIQTLVNKVVSEGSSEMHRESALEAIG--YICQDIRFGVMENQSNDVLTAIIHG 186
            .|:.|.   ..||..:|.:...:.|::. |:.|.:.||  |...|      :......|.::..|
  Rat  1607 FIDAPS---LALIMPIVQRAFQDRSTDT-RKMAAQIIGNMYSLTD------QKDLAPYLPSVTPG 1661

  Fly   187 MRK--VEPSNHVRLAATTALHNSLE-FTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLV 248
            ::.  ::|...||..:..||...:: ..:|.||..:.  ::||.:   |..|.|.....|.|.|.
  Rat  1662 LKASLLDPVPEVRTVSAKALGAMVKGMGESCFEDLLP--WLMETL---TYEQSSVDRSGAAQGLA 1721

  Fly   249 KIMT--------------------------------LYYQYM--------EPYMAQALFPITLAA 273
            ::|.                                :.:.|:        .||:. .:.|..|.|
  Rat  1722 EVMAGLGVEKLEKLMPEIVATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVG-PIIPCILKA 1785

  Fly   274 MKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVE---- 334
            :..:|:.|.               |.|:         ||.|||...||..|:..|.|.|.:
  Rat  1786 LADENEFVR---------------DTAL---------RAGQRVISMYAETAIALLLPQLEQGLFD 1826

  Fly   335 -------------------------KLTKQDECDDE----------------------------- 345
                                     |:|.:...:|:
  Rat  1827 DLWRIRFSSVQLLGDLLFHISGVTGKMTTETASEDDNFGTAQSNKAIITALGVDRRNRVLAGLYM 1891

  Fly   346 ---DTWSPAKAAS------------------------VCLMVLATCCED---------------- 367
               ||....:.||                        :.|..||:.|.|
  Rat  1892 GRSDTQLVVRQASLHVWKIVVSNTPRTLREILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKL 1956

  Fly   368 --EIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIV 430
              :|:|.::|.::|.:.|.....|....:....::.....:.:....|..:||..:.:.|....|
  Rat  1957 GEKILPEIIPILEEGLRSQKSDERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEV 2021

  Fly   431 RDTIAWTFGRIC---------DIIP-------EAAINETYLQTLLECF-VKSLKSEPRVAANVCW 478
            |:..|.||.::.         ||:|       :..::|..|..|.:.. |||....|.:...:..
  Rat  2022 REAAAKTFEQLHSTIGHQALEDILPFLLKQLDDEEVSEFALDGLKQVMAVKSRVVLPYLVPKLTT 2086

  Fly   479 AFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLLETTDRSDGAQANLRCAAYQALMDMIKN 543
            ..:.....|:.::|..|..|.....:.|.....:.:.|.|.|.      .|..|..||::..:::
  Rat  2087 PPVNTRVLAFLSSVAGDALTRHLGVILPAVMLALKEKLGTPDE------QLEMANCQAVILSVED 2145

  Fly   544 SP-----LDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVLRKVHEQ 603
            ..     ::..|...|:..|.:.:...::     :|.:..|.:         |...|.||
  Rat  2146 DTGHRIIIEDLLEATRSPEVGMRQAAAII-----LNMYCSRSK---------ADYTSHLR----- 2191

  Fly   604 DAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELL--GAQFAKYMPAFKDFLVMGLKN 666
                   ::::.|:.:||.|   |.||..|::.|::.:.:.|  |.|.|......|:...:|.:.
  Rat  2192 -------SLVSGLIRLFNDS---SPVVLGESWDALNAITKKLDAGNQLALIEEFHKEIRYIGNEC 2246

  Fly   667 FQEY--QVCCAAVGLTGDIFRALKDLMV---PYSNEIMTVLINNLTEPTIHRTVKPQVLSAFGDI 726
            ..|:  ..|....|:| .|...|::.::   |...|.....:..:...|....::|.|:|..|.:
  Rat  2247 RGEHVPGFCLPKKGVT-SILPVLREGVLTGSPEQKEEAAKALGLVIRLTSADALRPSVVSITGPL 2310

  Fly   727 ALSIGNHF--------LPYLSMVLDMLRVA-----SNLQT-------DAN--------------- 756
            ...:|:.|        |..||::|..:.:|     ..|||       |:|
  Rat  2311 IRILGDRFSWSVKAALLETLSLLLGKVGIALKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLI 2375

  Fly   757 --NFDMNEYINEL------------RESILEAYTGIIQGLKG-VDQTAHTDVMHMEPHLMHIISF 806
              :..::....||            |:::|:|...:|||... ||....          .:|:|.
  Rat  2376 SIHIKVDPLFTELLNGIRVVEDPGIRDTMLQALRFVIQGAGAKVDAAIR----------KNIVSL 2430

  Fly   807 IKRIAQEGDVSDSMLASAAGFIGDLC 832
            :  :...|...|:...|:||.:|:||
  Rat  2431 L--LGMLGHDEDNTRISSAGCLGELC 2454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	198/1055 (19%)
		IBN_N	27..107	CDD:281761	19/84 (23%)
		HEAT repeat	136..162	CDD:293787	7/27 (26%)
		HEAT repeat	179..209	CDD:293787	7/31 (23%)
		HEAT repeat	223..255	CDD:293787	9/63 (14%)
		HEAT repeat	264..291	CDD:293787	5/26 (19%)
		HEAT repeat	330..360	CDD:293787	10/114 (9%)
		HEAT repeat	373..401	CDD:293787	4/27 (15%)
		HEAT_EZ	386..441	CDD:290247	10/54 (19%)
		HEAT repeat	414..444	CDD:293787	8/38 (21%)
		HEAT repeat	457..482	CDD:293787	5/25 (20%)
		HEAT repeat	508..540	CDD:293787	7/31 (23%)
Gcn1	NP_001162135.1	DUF3554	355..705	CDD:288893
		HEAT repeat	1215..1249	CDD:293787
		HEAT repeat	1259..1290	CDD:293787
		HEAT repeat	1294..1325	CDD:293787
		HEAT repeat	1337..1364	CDD:293787
		HEAT repeat	1378..1403	CDD:293787
		HEAT repeat	1418..1447	CDD:293787
		HEAT repeat	1461..1485	CDD:293787
		ARM	1498..1601	CDD:237987	31/123 (25%)
		HEAT repeat	1498..1526	CDD:293787	8/23 (35%)
		HEAT repeat	1538..1568	CDD:293787	8/50 (16%)
		HEAT repeat	1577..1601	CDD:293787	9/27 (33%)
		HEAT repeat	1613..1642	CDD:293787	8/29 (28%)
		HEAT_2	1616..1721	CDD:290374	26/116 (22%)
		HEAT repeat	1660..1683	CDD:293787	6/22 (27%)
		HEAT repeat	1696..1725	CDD:293787	8/33 (24%)
		HEAT repeat	1734..1766	CDD:293787	1/31 (3%)
		HEAT repeat	1777..1802	CDD:293787	9/48 (19%)
		HEAT repeat	1813..1842	CDD:293787	3/28 (11%)
		HEAT repeat	1964..1992	CDD:293787	4/27 (15%)
		HEAT repeat	2005..2035	CDD:293787	8/29 (28%)
		HEAT repeat	2043..2067	CDD:293787	6/23 (26%)
		HEAT repeat	2073..2100	CDD:293787	3/26 (12%)
		HEAT repeat	2265..2289	CDD:293787	3/23 (13%)
		HEAT repeat	2310..2332	CDD:293787	4/21 (19%)
		HEAT repeat	2344..2374	CDD:293787	5/29 (17%)
		HEAT repeat	2383..2414	CDD:293787	6/30 (20%)
		HEAT repeat	2423..2452	CDD:293787	7/40 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910