DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and Apl

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_730182.1	Gene:	Apl / 59216	FlyBaseID:	FBgn0042178	Length:	1080	Species:	Drosophila melanogaster

Alignment Length:	889	Identity:	169/889 - (19%)
Similarity:	300/889 - (33%)	Gaps:	263/889 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PEFLKALSEILVNTANSAVARMAAGLQLKNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAA 104
            |:.|..|::|:::. .....|..|.:.||..:    :|:.     .|...|:|.:..||:|:|..
  Fly    34 PDSLLVLTQIVMSD-RPVQERQVAAVLLKRRV----KKLR-----HWQLVPAEHQAAIKSNMLQV 88

  Fly   105 LGTENTRPSCAAQCVAYVAVIELPI-NRWPMLIQTLVNKVVSEGSSEMHRESALEAIGYIC---- 164
            |                :||.|..: .....:|.:||..  .||.....||..|:.|...|
  Fly    89 L----------------IAVKEKTVKGTVAFIIGSLVRH--EEGEQNSWREEILKFIYERCSSPD 135

  Fly   165 -------QDIRFGVME------NQSNDVLTAIIHGMRKVEPSNHVRLAATTALHNSLEFTKSNFE 216
                   ..|...:|:      :...|.:..::.|:.....:|  ...||..:||.|  |.|
  Fly   136 PIESERGSSIFSSLMDAAPDQFSDHTDTMFPLLAGILVTAEAN--GNMATPTVHNML--TGS--- 193

  Fly   217 KDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQALFPITLAAMKSDNDAV 281
                 .|::..|...:..:  ||.|.|:..::|.:..:.:  :.|..:.:....:....:::...
  Fly   194 -----CFLLPFVSGHSNAE--QIVVKAVPLILKALAAFVE--KGYSIEFMGAFDIIDSMAEHVPH 249

  Fly   282 ALQG-----IEFWSNVC-DEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTP---VLVEKLT 337
            .|.|     :||...:. :::.|.:|..|..|..|...:...|...:..|  |.|   ||.|.:.
  Fly   250 LLTGNVKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKL--LQPTLSVLFEVIC 312

  Fly   338 KQD--ECDD-----EDTWSPAKAASVCLMVLAT-CCEDEIVPHVLPFIKENIESPNWRFRDAAVM 394
            :.|  |.||     |...||:.||:..|.::|. ...|:.:|.:|..::..::||....|.::.:
  Fly   313 QDDLEEGDDDYFSSESLSSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFI 377

  Fly   395 TFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGR--------ICDIIPEAAIN 451
            ..|.:..|......|..:|..:..:...:.||.:.||....:..|:        ||...|:
  Fly   378 CMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQ---- 438

  Fly   452 ETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLL 516
              .|..|.: ::..|..|.:|                       || |::..:...| |.:....
  Fly   439 --ILPVLFD-YLNQLVLELKV-----------------------GE-PDSKHMDRMF-YALETFC 475

  Fly   517 ETTDRSDGAQANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQ 581
            |..|.                 |::...|            .:::||..||:.:..
  Fly   476 ENLDE-----------------DIVPYLP------------TLMDRLFGVMEPQNS--------- 502

  Fly   582 FNDLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLG 646
             |.::.:..:.:.:|.....|...|.. ..|||.|.........|.  :..:...|:.||..|
  Fly   503 -NQMREMALSAIAAVSAAAKENLMPYF-PRIMTVLQGCLVKDCPKE--MYSQRIQAIDTLAAL-- 561

  Fly   647 AQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMT----VLINNLT 707
                                       |..:|         ||.::|.:::.|.    :|.:...
  Fly   562 ---------------------------CRELG---------KDNIIPLADDTMNFCLMMLEDGPD 590

  Fly   708 EPTIHRTVKPQVLSAFGDIALSIGNHFLPYLSMVL-------DML-RVASNLQTDANNFDM---- 760
            :|...|::...:.|....:..|:.:.|..::..::       ||: .|:.|...|....|.
  Fly   591 DPEYRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVIFSEDMVPNVSDNADDDLALVDAPDIE 655

  Fly   761 ------------------NEYINELRESILE-----AYTGIIQGLKGVDQTAHTDVMHMEPHLMH 802
                              |:||.|..|:||.     .:||  .......|:|..:|..|..|
  Fly   656 IDLEHTDDEDDQDAYPVENDYIVEKEEAILSLKEFATHTG--AAFAPYLQSAFENVYKMIDH--- 715

  Fly   803 IISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPRLYPLLDDA 846
                     .:|||..:.:.|...||..|         ..||||
  Fly   716 ---------PQGDVRMACIDSICSFITAL---------HKLDDA 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	169/889 (19%)
		IBN_N	27..107	CDD:281761	17/66 (26%)
		HEAT repeat	136..162	CDD:293787	9/25 (36%)
		HEAT repeat	179..209	CDD:293787	6/29 (21%)
		HEAT repeat	223..255	CDD:293787	7/31 (23%)
		HEAT repeat	264..291	CDD:293787	4/31 (13%)
		HEAT repeat	330..360	CDD:293787	14/39 (36%)
		HEAT repeat	373..401	CDD:293787	5/27 (19%)
		HEAT_EZ	386..441	CDD:290247	10/62 (16%)
		HEAT repeat	414..444	CDD:293787	7/37 (19%)
		HEAT repeat	457..482	CDD:293787	4/24 (17%)
		HEAT repeat	508..540	CDD:293787	4/31 (13%)
Apl	NP_730182.1	IBN_N	29..90	CDD:197981	17/81 (21%)
		HEAT repeat	356..384	CDD:293787	5/27 (19%)
		HEAT repeat	397..427	CDD:293787	5/29 (17%)
		HEAT repeat	438..473	CDD:293787	10/66 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438714
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940