DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and kpnb1

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_001032791.3	Gene:	kpnb1 / 570700	ZFINID:	ZDB-GENE-030131-2579	Length:	876	Species:	Danio rerio

Alignment Length:	876	Identity:	548/876 - (62%)
Similarity:	674/876 - (76%)	Gaps:	3/876 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MQLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHL 71
            |:||.|||||||||:|||.:|:.||||||..|||.||..||::|.|..|:.|||:|||||:||.|
Zfish     1 MELITILEKTVSPDRNELEAAQKFLEQAAIENLPTFLVELSKVLANPGNTQVARVAAGLQVKNSL 65

  Fly    72 TSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPINRWPMLI 136
            ||||.:|..|||.||....:..|..|||.:|..||||..|||.|:||||.:|..|:|:|:||.||
Zfish    66 TSKDPEVKSQYQQRWLAIDTSARREIKNYVLQTLGTETYRPSSASQCVAGIACAEIPVNQWPELI 130

  Fly   137 QTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAAT 201
            ..||..|....|:|..:||.|||||||||||....:::.:|.:|||||.||||.||||:|:||||
Zfish   131 PQLVANVTDPSSTEHMKESTLEAIGYICQDIDPEHLQDSANQILTAIIQGMRKEEPSNNVKLAAT 195

  Fly   202 TALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQAL 266
            .||.|||||||:||:|:.||:|||:||||||||.|:::.|||||.|||||:|||||||.||..||
Zfish   196 NALLNSLEFTKANFDKETERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPAL 260

  Fly   267 FPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPV 331
            |.||:.|||||.|.||||||||||||||||:|||||:.||::|||.|:..||.||:||||:|.|:
Zfish   261 FAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEATEASEQGRPPEHTSKFYAKGALQYLVPI 325

  Fly   332 LVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTF 396
            |.:.||||||.||:|.|:|.|||.||||:|||||||::||||||||||:|:.|:||:|||:||.|
Zfish   326 LTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDVVPHVLPFIKEHIKHPDWRYRDASVMAF 390

  Fly   397 GSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLEC 461
            ||:|.|.|.|.|||||.|||||||.||.|.||:||||.|||.|||||::|||||||.||..||:|
Zfish   391 GSILEGPELNQLKPLVIQAMPTLIELMKDPSVVVRDTTAWTLGRICDLLPEAAINEVYLSPLLQC 455

  Fly   462 FVKSLKSEPRVAANVCWAFIGLSDAAWEAA-VTNDGETPETYALSPYFEYIITQLLETTDRSDGA 525
            .::.|.:|||||:||||||..|::||:||. |.:|.|.|.||.||..||.|:.:|||||||.||.
Zfish   456 LIEGLGAEPRVASNVCWAFSSLAEAAYEATDVADDQEEPSTYCLSSSFELIVQKLLETTDRPDGH 520

  Fly   526 QANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLC 590
            |.|||.|||:|||:::|||..|||..||:|||||:|||.||:|||:.|.:.|||.||||||||||
Zfish   521 QNNLRSAAYEALMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLC 585

  Fly   591 ATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPA 655
            ||||:|||||..|||.||||.:|.:||.||.|:|| ||.|||:|.:|||||||:||:.|.|||.|
Zfish   586 ATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAG-SGGVQEDALMAVSTLVEVLGSDFLKYMDA 649

  Fly   656 FKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVL 720
            ||.||::||||:.|||||.|||||..|:.|||...::||.:|||.:|:.||....:||:||||:|
Zfish   650 FKPFLIIGLKNYAEYQVCLAAVGLVCDLCRALMANILPYCDEIMQLLLENLGNENVHRSVKPQIL 714

  Fly   721 SAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGLKGV 785
            |.||||||:||..|..||.:|||.|:.||..|.|..::||.:|:|||||..|||||||||||||.
Zfish   715 SVFGDIALAIGGEFKKYLDIVLDTLQQASQAQVDKTDYDMVDYLNELREGCLEAYTGIIQGLKGD 779

  Fly   786 DQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPRLYPLLD-DAIIT 849
            .:..|.|||.::|.:..|:|||..||::.|.||.::|:|.|.||||||:||..:..|:: ...|.
Zfish   780 QENVHPDVMLVQPRVEFILSFIHHIAEDEDRSDGVVANAVGLIGDLCTTFGKDVMKLVEVRPQIN 844

  Fly   850 QFLAEGKRSKAQRTKMLCTWAVKEIKKINTQ 880
            ..|.||:|||..:||.|.|||.||::|:.:|
Zfish   845 DLLTEGRRSKTSKTKTLATWAAKELRKLKSQ 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	538/860 (63%)
		IBN_N	27..107	CDD:281761	44/79 (56%)
		HEAT repeat	136..162	CDD:293787	12/25 (48%)
		HEAT repeat	179..209	CDD:293787	22/29 (76%)
		HEAT repeat	223..255	CDD:293787	23/31 (74%)
		HEAT repeat	264..291	CDD:293787	20/26 (77%)
		HEAT repeat	330..360	CDD:293787	19/29 (66%)
		HEAT repeat	373..401	CDD:293787	19/27 (70%)
		HEAT_EZ	386..441	CDD:290247	39/54 (72%)
		HEAT repeat	414..444	CDD:293787	23/29 (79%)
		HEAT repeat	457..482	CDD:293787	15/24 (63%)
		HEAT repeat	508..540	CDD:293787	22/31 (71%)
kpnb1	NP_001032791.3	KAP95	2..871	CDD:227540	545/869 (63%)
		IBN_N	21..101	CDD:281761	44/79 (56%)
		HEAT repeat	129..159	CDD:293787	16/29 (55%)
		HEAT repeat	172..204	CDD:293787	23/31 (74%)
		HEAT repeat	217..243	CDD:293787	18/25 (72%)
		HEAT repeat	256..286	CDD:293787	22/29 (76%)
		HEAT repeat	323..354	CDD:293787	19/30 (63%)
		ARM	365..479	CDD:237987	79/113 (70%)
		HEAT repeat	367..395	CDD:293787	19/27 (70%)
		HEAT repeat	408..438	CDD:293787	23/29 (79%)
		HEAT repeat	451..476	CDD:293787	15/24 (63%)
		HEAT repeat	503..535	CDD:293787	22/31 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595675
Domainoid	1	1.000	506	1.000	Domainoid score	I319
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1707
Inparanoid	1	1.050	1073	1.000	Inparanoid score	I239
OMA	1	1.010	-	-		QHG56400
OrthoDB	1	1.010	-	-		D222415at33208
OrthoFinder	1	1.000	-	-		FOG0003173
OrthoInspector	1	1.000	-	-		oto41541
orthoMCL	1	0.900	-	-		OOG6_101642
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2136
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910