DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and ipo4

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	XP_684163.4	Gene:	ipo4 / 553305	ZFINID:	ZDB-GENE-041014-307	Length:	1085	Species:	Danio rerio

Alignment Length:	1021	Identity:	210/1021 - (20%)
Similarity:	361/1021 - (35%)	Gaps:	273/1021 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHLT 72
            :|..:|.:...||...:..|...|:||...  |..:.||..::..:.|..| |.:|.:.|:
Zfish     4 ELERVLTRLTEPDNAVIQQATAELKQAFKD--PAIIPALCAVMTGSQNPQV-RQSAAVMLR---- 61

  Fly    73 SKDEKVSQQYQDRWHQFPSEIRELIKNNILAAL--GTENTRPSCAAQCVAYVAVIELPINRWPML 135
                   .:.:.:|.:...:.||.:|..:|.|.  .||:|.....:|..|.:...|.| :|||.|
Zfish    62 -------MRVRKQWKKISPDHRESLKAVVLQAFQQETEHTVRHSLSQLSAVLVKHETP-DRWPAL 118

  Fly   136 IQ------------------TLVNKVVSEGSS----EMHRESALEAIGYICQDIRFGVMENQSND 178
            ::                  .|::|||  ||:    :.|.:..|:..|.:.||:...........
Zfish   119 LELLNQSTKSNNPQDRQVGLLLLSKVV--GSNPEPFKPHYKQLLQLFGTVLQDLNNPTALYYCIL 181

  Fly   179 VLTAI--------IHGMRKVEPS-----NHVRLAATTALHNSLEFTKSNFEKDMER--------- 221
            .||||        ::.||.:.|.     .|:..|.......::|.    |::.||.
Zfish   182 TLTAITAYTGTEEMNLMRSLIPKLLVALKHLIQADQDQASEAMEV----FDELMESEVSIVVPHI 242

  Fly   222 ----NFIMEVVCEATQCQDSQI----CVAALQCLVKIMTLYYQYMEPYMAQALFPITLAAM---K 275
                .|.:|:..:|:.....::    |:|.|..|.....|.::.::|.: |.:|||..||.   :
Zfish   243 AEIVRFCLEISADASLSDSLRVKALSCIAVLIRLKNKAVLKHKLLQPIL-QVVFPILSAAPPPGE 306

  Fly   276 SDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLV----EKL 336
            .|.:              |||.|...:|:.           .||:   |:|.:..:.:    |||
Zfish   307 EDPE--------------DEENDTGGDSEN-----------PKHF---AVQVIDTMALHMPPEKL 343

  Fly   337 TKQ-----DECDDEDTWSPAKAASVCLMVLATCCEDEI----VPHVLPFIKENIESPNWRFRDAA 392
            ..|     ..|...:.....|...:|:.|||..|.|.|    :..:|..:..::...|...|.||
Zfish   344 FNQLLPFTQACLSSENPYERKGGLMCMAVLAEGCADHIRTKMLSSMLQTVCRSLSDNNQVVRSAA 408

  Fly   393 VMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDT----IAWTFGRICDIIPEAAIN-E 452
            :...|..     :..|:|.|.:....|:.|:......|..|    :...|..:.:.:...... |
Zfish   409 LFALGQF-----SEHLQPDVSKFHAELMPLLQGYLSAVNQTKIGHMTKAFYALENFLENLGQEIE 468

  Fly   453 TYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEA--AVTNDGETPETYALSPYFEYII--- 512
            .||.:|:|..:.:|.:.         ..:.|.:.|..|  |:.|    ..|..|.|||..||
Zfish   469 PYLPSLMETMLSALNNA---------EILKLKELAVSAIGAIAN----AATEMLVPYFPPIIDSL 520

  Fly   513 ---------------TQLLET---------------------------TDRSDGAQANLRCAAYQ 535
                           ||.|:|                           ||..|  ..:||...|.
Zfish   521 KGFLTDTREEMRALQTQALDTLSVLARTVGKDVFSPLAAECVQLGLNLTDAVD--DPDLRRCTYS 583

  Fly   536 ALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVLRKV 600
            ....:.:.|| || |....|::..:.:|:  ::....:..|.|..:            |.||...
Zfish   584 LFSAVSEVSP-DC-LTPHLTSITTVMQLS--LRSTEGVTAHLDEDK------------QFVLLDD 632

  Fly   601 HEQDAPQISDAIMTALLTMFNSSAGK--------SGVVQEEAFL-----AVSTLVEL---LGAQF 649
            .:.|..:..|||:        ...|:        :|...|.|::     |...|.|:   .|..|
Zfish   633 DDADDGEEGDAIL--------DDEGETEVDDRDVAGFSVENAYIDEKEDACDALGEIAFNTGVAF 689

  Fly   650 AKYM-PAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTI-- 711
            ..:: .:|:.  |..|::|....|..||.|..|...||...:......|....:::.|.|..:
Zfish   690 QPFLESSFQQ--VYDLRDFPHEDVRKAAFGAMGQFCRAQHKVWKENPTEANHQVLHKLLEVILPC 752

  Fly   712 ---------HRTVKPQVLSAFGDI-------ALSIGNHFLPYLSMVLDMLRVASNLQ-TDANNFD 759
                     .|.|...:|.|...:       ||..........:::.|:|:..:..| ...:..|
Zfish   753 FLEAVKQDRERQVVMAILEAMNSVIKSCQGEALQAPGRLAEISNVIKDVLKKKTVCQDVGGDEAD 817

  Fly   760 MNEYINELRESILEAYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFI----KRIAQEGDVSDSM 820
            .:|...|. :::|:.:.|  :|:..:......:..:  |||..::..|    |....|.|.|.|:
Zfish   818 DDEQQAEF-DAMLQEFAG--EGIPALASAVPAETFY--PHLNDLLPLIMSKTKSSCTEADRSFSI 877

  Fly   821 LASAAGFIGDLCTSF-----GPRLYPLLDDAIITQFLAEGKRSKAQ 861
                 |.||:...|.     |..:...|.:.::...:|..|.|.|:
Zfish   878 -----GTIGETLHSLVAVAGGRAVAGRLSNRLLPVLVAGVKDSDAE 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	208/1012 (21%)
		IBN_N	27..107	CDD:281761	18/81 (22%)
		HEAT repeat	136..162	CDD:293787	8/47 (17%)
		HEAT repeat	179..209	CDD:293787	9/42 (21%)
		HEAT repeat	223..255	CDD:293787	8/35 (23%)
		HEAT repeat	264..291	CDD:293787	7/29 (24%)
		HEAT repeat	330..360	CDD:293787	7/38 (18%)
		HEAT repeat	373..401	CDD:293787	6/27 (22%)
		HEAT_EZ	386..441	CDD:290247	12/58 (21%)
		HEAT repeat	414..444	CDD:293787	5/33 (15%)
		HEAT repeat	457..482	CDD:293787	3/24 (13%)
		HEAT repeat	508..540	CDD:293787	13/76 (17%)
ipo4	XP_684163.4	IBN_N	23..89	CDD:197981	18/79 (23%)
		KAP95	49..710	CDD:227540	155/754 (21%)
		HEAT repeat	347..375	CDD:293787	5/27 (19%)
		HEAT_EZ	360..415	CDD:290247	14/54 (26%)
		HEAT repeat	388..418	CDD:293787	6/34 (18%)
		HEAT repeat	429..458	CDD:293787	5/28 (18%)
		HEAT repeat	471..501	CDD:293787	7/38 (18%)
		HEAT_EZ	489..545	CDD:290247	16/59 (27%)
		HEAT repeat	663..685	CDD:293787	5/21 (24%)
		HEAT repeat	695..739	CDD:293787	12/45 (27%)
		HEAT repeat	748..775	CDD:293787	4/26 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910