DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and tnpo2

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_001004003.1	Gene:	tnpo2 / 445499	ZFINID:	ZDB-GENE-040822-16	Length:	889	Species:	Danio rerio

Alignment Length:	839	Identity:	180/839 - (21%)
Similarity:	320/839 - (38%)	Gaps:	190/839 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVN-TANSAVARMAAGLQLKNHL 71
            |::.:|..:.||:.....:.:..|||  .:..|:|...|..:|.. .......|..:||.|||:
Zfish    12 QVLQLLRDSQSPNTATQRAVQQKLEQ--LNQFPDFNNYLIFVLTRLKTEDEPTRSLSGLILKNN- 73

  Fly    72 TSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIEL--PINRWPM 134
                  |...||:    ||..:...||...|..:|  :..|...|.....:..|..  .:..||.
Zfish    74 ------VKVHYQN----FPPAVAHFIKQECLNNIG--DPSPLIRATIGILITTISTKGELQTWPE 126

  Fly   135 LIQTLVNKVVSEGSSEMHRESALEAIGYICQD----IRFGVMENQSNDVLTAIIHGMRKVEPSNH 195
            |:..|.|.:.||..:..  |.:..|:..||:|    :....:....|.::...:...:...|.
Zfish   127 LLPQLCNMLDSEDYNIC--EGSFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPK-- 187

  Fly   196 VRLAATTALHNSLEFTKSNFEKDMER-NFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYME 259
            :|..|...::   :|..|..:..|:. :..:|.:...:..:||::.....:.||.::.:....:.
Zfish   188 IRSHAVACVN---QFIISRAQALMDNIDTFIESLFALSSDEDSEVRKNVCRALVMLLEVRVDRLL 249

  Fly   260 PYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGA 324
            |:| :::....|...:..::.|:|:..|||..:                   |.|.:.|....|.
Zfish   250 PHM-RSIVEYMLQRTQDPDENVSLEACEFWLTL-------------------AEQPICKDVLSGH 294

  Fly   325 LQFLTPVLVEKL---------------------------------------------------TK 338
            |..|.||||..:                                                   ::
Zfish   295 LAQLVPVLVNGMKYSEIDIILLKGDVEEDEAVPDNEQDIKPRFHKSRTVTLRHEGDEGEEGEDSE 359

  Fly   339 QDECDDEDT---WSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVL 400
            .|:.||:|:   |:..|.::..|.|||....||::||:||.:||.:..|:|..:::.::..|::.
Zfish   360 DDDDDDDDSLSDWNLRKCSAAALDVLANVFRDELLPHLLPVLKELLFHPDWVVKESGILVLGAIA 424

  Fly   401 NGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICD-IIPEAAINETYLQTLL-ECFV 463
            .|...:.:..|.| .:|.|::.:.|...:||....||..|... ::.:.|  ::||:.|: |...
Zfish   425 EGCMQDMVLYLPE-LIPHLVQCLCDKKALVRSIACWTLSRYAHWVVSQPA--DSYLKPLMTELLK 486

  Fly   464 KSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLLETTDR------- 521
            :.|.|..:|....|.||..|.    |.|.|.         |.||..||:..|:....:
Zfish   487 RILDSNKKVQEAACSAFATLE----EEACTE---------LVPYLSYILDTLVFAFSKYQHKNLL 538

  Fly   522 ---------SDGAQANLRCAAY-QALM-------DMIKNSPLD---------------------- 547
                     :|....:|....| |.||       :.:|:...|
Zfish   539 ILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLPY 603

  Fly   548 CYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCA-TLQSVLRKVHEQDAPQI--S 609
            |..|.||...::.:.|.|.|    ..|...::::..|...::.| .|.|.|.:....:..|:  .
Zfish   604 CEPVYQRCVTLVQKNLAQAM----MYNQQPEQYEAPDKDFMIVALDLLSGLAEGLGANVEQLVTR 664

  Fly   610 DAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFL-VMGLKNFQEY-QV 672
            ..|||.|......:..:   |::.:|   :.|.:|..|.|....|...:|: |:||....|: .|
Zfish   665 SNIMTLLFQCMQDTMPE---VRQSSF---ALLGDLTKACFLHVKPCVAEFMPVLGLNLNPEFISV 723

  Fly   673 CCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVLSAFGDIALSIG 731
            |..|....|:|...:...|.|:    :.:::|||.| .|:|...|:.|  ..:.|::||
Zfish   724 CNNATWAIGEITMQMGTEMQPF----VALVLNNLVE-IINRPNTPKTL--LENTAITIG 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	178/830 (21%)
		IBN_N	27..107	CDD:281761	21/80 (26%)
		HEAT repeat	136..162	CDD:293787	6/25 (24%)
		HEAT repeat	179..209	CDD:293787	3/29 (10%)
		HEAT repeat	223..255	CDD:293787	5/31 (16%)
		HEAT repeat	264..291	CDD:293787	6/26 (23%)
		HEAT repeat	330..360	CDD:293787	11/83 (13%)
		HEAT repeat	373..401	CDD:293787	7/27 (26%)
		HEAT_EZ	386..441	CDD:290247	12/54 (22%)
		HEAT repeat	414..444	CDD:293787	8/30 (27%)
		HEAT repeat	457..482	CDD:293787	8/25 (32%)
		HEAT repeat	508..540	CDD:293787	9/55 (16%)
tnpo2	NP_001004003.1	IBN_N	32..99	CDD:281761	22/81 (27%)
		HEAT repeat	93..114	CDD:293787	4/22 (18%)
		ARM	125..240	CDD:237987	23/121 (19%)
		HEAT repeat	127..155	CDD:293787	8/29 (28%)
		HEAT repeat	165..202	CDD:293787	5/41 (12%)
		HEAT repeat	213..239	CDD:293787	4/25 (16%)
		HEAT_EZ	228..275	CDD:290247	7/47 (15%)
		HEAT repeat	252..281	CDD:293787	7/29 (24%)
		HEAT repeat	397..425	CDD:293787	7/27 (26%)
		HEAT_2	398..502	CDD:290374	27/106 (25%)
		HEAT_EZ	410..464	CDD:290247	12/54 (22%)
		HEAT repeat	437..467	CDD:293787	9/30 (30%)
		HEAT repeat	476..505	CDD:293787	10/28 (36%)
		HEAT repeat	667..695	CDD:293787	8/33 (24%)
		HEAT repeat	707..737	CDD:293787	10/29 (34%)
		HEAT repeat	748..776	CDD:293787	11/31 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910