DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and ipo9

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_998704.1	Gene:	ipo9 / 406860	ZFINID:	ZDB-GENE-040426-2953	Length:	1043	Species:	Danio rerio

Alignment Length:	1005	Identity:	181/1005 - (18%)
Similarity:	340/1005 - (33%)	Gaps:	308/1005 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LEKTVSPDKNELLSAKNFLEQAAASNL------PEFLKALSEILVNTANSAVARMAAGLQLK--- 68
            |::|:....|.:||....:..||...:      .||...|:|:.|:...:...|..|.:.||
Zfish    22 LKETLIDALNAILSPVQEVRAAAEERIKVLEVTEEFGVHLAELTVDPHGALAIRQLASVILKQYV 86

  Fly    69 -NHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPINRW 132
             .|..::.||........|.:  :.||||:.:.:..|:....   |..|..::.:|..:.| ..|
Zfish    87 ETHWCARSEKYRPPETTEWAK--AAIRELLPSGLREAISKVR---SSVAYALSAIAHWDWP-EAW 145

  Fly   133 PMLIQTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVR 197
            |.|.:.|::.:.|...:.:|  .|:..:....::    |.:.|..||...|:..|.|:.....|.
Zfish   146 PGLFKLLMDMLASGDVNAVH--GAMRVLTEFTRE----VTDVQMPDVAPVILPQMYKIFTMAEVY 204

  Fly   198 LAATTALHNSLEFTKSNF-------EKDMERNFIMEVVCEATQC------------QDSQICVAA 243
            ...|.:....:..|.:|.       .|......|..||.:.|:.            .||.:.:..
Zfish   205 SIRTRSRAVEIFTTCANLICAIDEVAKGAANALIFPVVQQFTEAFIQALQIPDGPTSDSGLKMEV 269

  Fly   244 LQCLVKIMTLYYQYMEPYMAQALFPI---TLA-------------------AMKSDNDAVALQGI 286
            |:.:..::..:.:.|...|.|.| ||   ||.                   .:.||.:.:..:.:
Zfish   270 LKAVTALVKNFPKPMVSSMQQIL-PIVWNTLTESASFYVRTEVNYTEEVDDPVDSDGEVLGFENL 333

  Fly   287 EFWSNVCDEEIDLAIESQ--EATDQGRAPQRVSKHYARGALQFLTPVLVEKLTKQD--------- 340
            .|   ...|.:...:|::  ::|.:...|:.:  :|.         :|..::|:..
Zfish   334 VF---SIFEFVHTLLENKKFKSTVKKALPELI--YYI---------ILYMQITEDQIKVWTANPQ 384

  Fly   341 ---ECDDEDTWSPAKAASVCLMVLATCCEDE------IVPHVLPFIKENIESPN------WRFRD 390
               |.:|:||:|.:...|...::||...|.:      :.......::|..::.|      |:..:
Zfish   385 QFVEDEDDDTFSYSVRISAQDLLLAVAAEFQNESAAALAAAATRHLQEAEQAKNTGSEHWWKVHE 449

  Fly   391 AAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRD------------TIAWTFGRICD 443
            |.::..|||...:..|.....|:..|...:     ::||:.|            ...|...|.
Zfish   450 ACMLALGSVKTIITENVKNGRVQFDMHGFL-----ANVILADLNLPAASPFLLGRALWAASRF-- 507

  Fly   444 IIPEAAINETYLQTLLECFVKSL-KSEP---RVAA-NVCWAF---IGLSDAAWEAAVTNDGETPE 500
               .||::...:|..|:..|..| :|:|   |::| ...|.:   :.||::
Zfish   508 ---TAAMSPELIQQFLQATVSGLHESQPPSVRISAVRAIWGYCDQLKLSES-------------- 555

  Fly   501 TYALSPYFEYIITQLLE---------------------TTDRSDGAQA-NLRCAAYQALMDMIKN 543
            |:.|.|:...::..|::                     |.|.:....| |..|....|:.....|
Zfish   556 THVLQPFLPSVLEGLVQLAAQFSSEVLTLVMETLCIVCTVDPAFTTSAENKICPLTIAIFLKYSN 620

  Fly   544 SPLDCYLVVQRTTLVILERLNQV------MQME------TQINNHSDRHQFNDLQSLLCATLQSV 596
            .|     ||......|.:.|.|:      |||.      :.:....|:     :.|.||||...:
Zfish   621 DP-----VVASLAQDIFKELAQIEACQGPMQMRLIPTLVSIMQAPPDK-----IPSGLCATSIDI 675

  Fly   597 LRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAV---------STLVELLGAQFAKY 652
            |..|.....|.:||.::.                  :||.||         :|.::..|    :.
Zfish   676 LTTVVRNTKPPLSDMLVC------------------QAFPAVAQCTLRTDDNTTMQNGG----EC 718

  Fly   653 MPAFKDFLVMGLKNFQEYQVCCAAVGLTG--DIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTV 715
            :.|:....:..:..:|:.|      |.:|  .:.:.:..|:.|.::|.....:..|....|.|.
Zfish   719 LRAYVSVALEQIARWQDEQ------GHSGLWYVMQVVSQLLDPRTSEFTAAFVGRLVSTLITRA- 776

  Fly   716 KPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQ 780
                       ...:.:.....|..:|..::.|..|              .:.:|::..:.
Zfish   777 -----------GTQLADQLDQILRAILSKMQQAETL--------------SVMQSLIMVFA---- 812

  Fly   781 GLKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPRLYPLLDD 845
                              ||:|                |.|.....|   ||:..||...|.| :
Zfish   813 ------------------HLVH----------------SQLEPLLEF---LCSLPGPTGKPAL-E 839

  Fly   846 AIITQFLA---------EGKRSKAQRTKML 866
            .::.::::         |||.|.....|:|
Zfish   840 FVMAEWMSRQHLFYGQYEGKVSAVALCKLL 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	179/1001 (18%)
		IBN_N	27..107	CDD:281761	20/89 (22%)
		HEAT repeat	136..162	CDD:293787	4/25 (16%)
		HEAT repeat	179..209	CDD:293787	6/29 (21%)
		HEAT repeat	223..255	CDD:293787	7/43 (16%)
		HEAT repeat	264..291	CDD:293787	9/48 (19%)
		HEAT repeat	330..360	CDD:293787	8/41 (20%)
		HEAT repeat	373..401	CDD:293787	7/33 (21%)
		HEAT_EZ	386..441	CDD:290247	12/66 (18%)
		HEAT repeat	414..444	CDD:293787	6/41 (15%)
		HEAT repeat	457..482	CDD:293787	8/32 (25%)
		HEAT repeat	508..540	CDD:293787	7/53 (13%)
ipo9	NP_998704.1	CSE1	35..814	CDD:227944	159/915 (17%)
		IBN_N	44..118	CDD:197981	18/75 (24%)
		HEAT repeat	518..545	CDD:293787	7/26 (27%)
		HEAT repeat	563..589	CDD:293787	1/25 (4%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910