DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and Tnpo

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_001261472.1	Gene:	Tnpo / 38721	FlyBaseID:	FBgn0024921	Length:	893	Species:	Drosophila melanogaster

Alignment Length:	968	Identity:	192/968 - (19%)
Similarity:	346/968 - (35%)	Gaps:	229/968 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVN-TANSAVARMAAGLQLKNHL 71
            |:||||:::.|||....::.:..||:  .:..|:|...|..:|.. .......|..:||.|||::
  Fly    12 QIIAILKESQSPDTATQMAVQMKLEE--FNRYPDFNNYLIYVLTKLKTEDEPTRSLSGLILKNNI 74

  Fly    72 TSKDEKVSQQYQDRWH--QFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIEL--PINRW 132
                         |.|  ....||.|.||:..|.|:|  :..|...|.....:..|..  .::.|
  Fly    75 -------------RMHGTTLQPEIVEYIKHECLQAVG--DASPLIRATVGILITTIASNGGLHNW 124

  Fly   133 PMLIQTLVNKVVSEGSSEMHRESALEAIGYICQD----IRFGVMENQSNDVLTAIIHGMRKVEPS 193
            |.|:.:|...:.::..:..  |.|..|:..||:|    :....:....|.::...:...:...|.
  Fly   125 PQLLPSLCEMLDNQDYNVC--EGAFSALQKICEDSAEILDSAALNRPLNIMIPKFLEYFKHSSPK 187

  Fly   194 --NHVRLAATTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQ 256
              :|........:.|..:....|.:..:|..|      ..:..:|.::.......||.::.:...
  Fly   188 IRSHAIACINQFIINRSQALMLNIDSFIENLF------HLSSDEDHEVRKNVCHGLVMLLEVRMD 246

  Fly   257 YMEPYMAQALFPITLAAMKSDNDAVALQGIEFW-----SNVCDE--------------------E 296
            .:.|:|:|.:..:.|....:| :.|||:..|||     .::|.:                    |
  Fly   247 RLMPHMSQIIEYMLLRTQDTD-EGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSE 310

  Fly   297 IDLAIESQEATDQGRAPQRVSK-----HYARGALQFLTPVLVEKLTKQDECD------DEDT--- 347
            :|:.:......:....|.|...     |.:|......|.......|..|:.|      |:|:
  Fly   311 VDIILLKGNVEEDDMVPDREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFEDGMDDDSSLS 375

  Fly   348 -WSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPL 411
             |:..|.::..|.|||....::.:|.|||.:||.:....|..:::.|:..|::..|.....::.|
  Fly   376 EWNLRKCSAAALDVLANVFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEGCMQGMIQHL 440

  Fly   412 VEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLECFVKS-LKSEPRVAAN 475
            .| .:|.||..:.|...:||....||..|..:.:.... ::.||:.|:|..:|. |.|..||...
  Fly   441 PE-LIPYLISCLSDKKALVRSITCWTLSRYANWVVNQP-HDQYLKPLMEELLKRILDSNKRVQEA 503

  Fly   476 VCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLLETTDR----------------SDG 524
            .|.||..|.    |.|.|.         |.||.|||:..|:....:                :|.
  Fly   504 ACSAFATLE----EEACTE---------LVPYLEYILKTLVFAFSKYQHKNLLILYDAVGTLADS 555

  Fly   525 AQANLRCAAYQALM--------DMIKNSPLD----------------------CYLVVQRTTLVI 559
            ...:|....|..::        :::|:...|                      |..|.:|...:|
  Fly   556 VGHHLNKPQYIDILMPPLIDKWNLLKDDDKDLFPLLECLSSIATALQSGFLPYCDPVYRRCISLI 620

  Fly   560 LERLNQVMQ-METQINNHSDRHQFNDLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNSS 623
            .:.:||.|. .:.|..:|.|:.:......||....:.:.|.:
  Fly   621 EQTINQEMLCKQNQTYDHPDKERMIVALDLLSGLAEGLDRHI----------------------- 662

  Fly   624 AGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALK 688
                     |..:|.|.::.||.......:|                :|..::..|.||:.:|..
  Fly   663 ---------ETLVANSNIMHLLYQCMQDVLP----------------EVRQSSFALLGDLTKACF 702

  Fly   689 DLMVPYSNEIMTVLINNLTEPTIHRTVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQT 753
            ..:.|:..:...:|..||....|  :|......|.|:|.:.:|.....|:.:||..|.:..|...
  Fly   703 PHVHPFMADFFPILGQNLNPDFI--SVCNNATWAIGEICMKLGEETKQYIRLVLSDLFIIINRPN 765

  Fly   754 DANNFDMNEYINELRESILEAYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFIK------RIAQ 812
            ..             :::|| .|.|..|..|     :...:.:.|:|.   .|::      |..:
  Fly   766 TP-------------KTLLE-NTAITIGRLG-----YVCPVEVAPYLP---EFVRQWCTSLRHIR 808

  Fly   813 EGDVSDS--------MLASAAGFIGD---LCTSFGPRLYPLLDDAIITQFLAEGKRSK 859
            :.|..||        :..:.||.:.|   .|.:....:.|..|...:.|.:..|.:::
  Fly   809 DNDEKDSAFRGMCHMITVNPAGVVADFIFFCDAIASWVNPPEDLHQMIQKILHGFKTQ 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	187/959 (19%)
		IBN_N	27..107	CDD:281761	21/82 (26%)
		HEAT repeat	136..162	CDD:293787	4/25 (16%)
		HEAT repeat	179..209	CDD:293787	3/31 (10%)
		HEAT repeat	223..255	CDD:293787	4/31 (13%)
		HEAT repeat	264..291	CDD:293787	9/31 (29%)
		HEAT repeat	330..360	CDD:293787	8/39 (21%)
		HEAT repeat	373..401	CDD:293787	8/27 (30%)
		HEAT_EZ	386..441	CDD:290247	14/54 (26%)
		HEAT repeat	414..444	CDD:293787	9/29 (31%)
		HEAT repeat	457..482	CDD:293787	10/25 (40%)
		HEAT repeat	508..540	CDD:293787	7/55 (13%)
Tnpo	NP_001261472.1	IBN_N	32..99	CDD:281761	22/83 (27%)
		ARM	127..234	CDD:237987	16/114 (14%)
		HEAT repeat	127..155	CDD:293787	6/29 (21%)
		HEAT repeat	172..202	CDD:293787	2/29 (7%)
		HEAT repeat	213..239	CDD:293787	4/31 (13%)
		HEAT repeat	252..281	CDD:293787	10/29 (34%)
		HEAT_2	399..507	CDD:290374	31/109 (28%)
		HEAT repeat	402..430	CDD:293787	8/27 (30%)
		HEAT_EZ	415..469	CDD:290247	14/54 (26%)
		HEAT repeat	442..472	CDD:293787	10/30 (33%)
		HEAT repeat	481..510	CDD:293787	12/28 (43%)
		HEAT repeat	670..702	CDD:293787	8/47 (17%)
		HEAT repeat	711..737	CDD:293787	6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438721
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940