DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and KPNB1

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_002256.2	Gene:	KPNB1 / 3837	HGNCID:	6400	Length:	876	Species:	Homo sapiens

Alignment Length:	876	Identity:	540/876 - (61%)
Similarity:	676/876 - (77%)	Gaps:	3/876 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MQLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHL 71
            |:||.|||||||||:.||.:|:.|||:||..|||.||..||.:|.|..||.|||:|||||:||.|
Human     1 MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSL 65

  Fly    72 TSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPINRWPMLI 136
            ||||..:..|||.||....:..|..:||.:|..||||..|||.|:||||.:|..|:|:|:||.||
Human    66 TSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAEIPVNQWPELI 130

  Fly   137 QTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAAT 201
            ..||..|.:..|:|..:||.|||||||||||....::::||::|||||.||||.||||:|:||||
Human   131 PQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAAT 195

  Fly   202 TALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQAL 266
            .||.|||||||:||:|:.||:|||:||||||||.|:::.|||||.|||||:|||||||.||..||
Human   196 NALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPAL 260

  Fly   267 FPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPV 331
            |.||:.|||||.|.||||||||||||||||:|||||:.||.:|||.|:..||.||:||||:|.|:
Human   261 FAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPI 325

  Fly   332 LVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTF 396
            |.:.||||||.||:|.|:|.|||.||||:|||||||:|||||||||||:|::|:||:||||||.|
Human   326 LTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAF 390

  Fly   397 GSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLEC 461
            |.:|.|.|.:.|||||.|||||||.||.|.||:||||.|||.||||:::||||||:.||..||:|
Human   391 GCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQC 455

  Fly   462 FVKSLKSEPRVAANVCWAFIGLSDAAWEAA-VTNDGETPETYALSPYFEYIITQLLETTDRSDGA 525
            .::.|.:|||||:||||||..|::||:||| |.:|.|.|.||.||..||.|:.:|||||||.||.
Human   456 LIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGH 520

  Fly   526 QANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLC 590
            |.|||.:||::||:::|||..|||..||:|||||:|||.||:|||:.|.:.|||.||||||||||
Human   521 QNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLC 585

  Fly   591 ATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPA 655
            ||||:|||||..|||.||||.:|.:||.||.|:|| ||.|||:|.:|||||||:||.:|.|||.|
Human   586 ATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAG-SGGVQEDALMAVSTLVEVLGGEFLKYMEA 649

  Fly   656 FKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVL 720
            ||.||.:||||:.|||||.|||||.||:.|||:..::|:.:|:|.:|:.||....:||:||||:|
Human   650 FKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQIL 714

  Fly   721 SAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGLKGV 785
            |.||||||:||..|..||.:||:.|:.||..|.|.:::||.:|:||||||.|||||||:|||||.
Human   715 SVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGD 779

  Fly   786 DQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPRLYPLLD-DAIIT 849
            .:..|.|||.::|.:..|:|||..||.:.|.:|.::|.|||.||||||:||..:..|:: ..:|.
Human   780 QENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIH 844

  Fly   850 QFLAEGKRSKAQRTKMLCTWAVKEIKKINTQ 880
            :.|.||:|||..:.|.|.|||.||::|:..|
Human   845 ELLTEGRRSKTNKAKTLATWATKELRKLKNQ 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	530/860 (62%)
		IBN_N	27..107	CDD:281761	42/79 (53%)
		HEAT repeat	136..162	CDD:293787	12/25 (48%)
		HEAT repeat	179..209	CDD:293787	22/29 (76%)
		HEAT repeat	223..255	CDD:293787	23/31 (74%)
		HEAT repeat	264..291	CDD:293787	20/26 (77%)
		HEAT repeat	330..360	CDD:293787	19/29 (66%)
		HEAT repeat	373..401	CDD:293787	19/27 (70%)
		HEAT_EZ	386..441	CDD:290247	38/54 (70%)
		HEAT repeat	414..444	CDD:293787	23/29 (79%)
		HEAT repeat	457..482	CDD:293787	15/24 (63%)
		HEAT repeat	508..540	CDD:293787	20/31 (65%)
KPNB1	NP_002256.2	HEAT repeat	367..395	CDD:293787	19/27 (70%)
		HEAT 10. /evidence=ECO:0000269\|PubMed:10353244, ECO:0000269\|PubMed:10367892	402..438		28/35 (80%)
		HEAT repeat	408..438	CDD:293787	23/29 (79%)
		HEAT 11. /evidence=ECO:0000269\|PubMed:10353244	449..485		20/35 (57%)
		HEAT repeat	451..476	CDD:293787	15/24 (63%)
		HEAT 12. /evidence=ECO:0000269\|PubMed:10353244	500..537		21/36 (58%)
		HEAT repeat	503..535	CDD:293787	20/31 (65%)
		HEAT 13. /evidence=ECO:0000269\|PubMed:10353244	544..592		34/47 (72%)
		HEAT 14. /evidence=ECO:0000269\|PubMed:10353244	600..639		26/39 (67%)
		HEAT 15. /evidence=ECO:0000269\|PubMed:10353244	644..681		25/36 (69%)
		HEAT 16. /evidence=ECO:0000269\|PubMed:10353244	686..724		20/37 (54%)
		HEAT 17. /evidence=ECO:0000269\|PubMed:10353244	732..776		25/43 (58%)
		HEAT 18. /evidence=ECO:0000269\|PubMed:10353244	786..829		22/42 (52%)
		HEAT 19. /evidence=ECO:0000269\|PubMed:10353244	831..873		16/41 (39%)
		KAP95	2..871	CDD:227540	537/869 (62%)
		HEAT 1. /evidence=ECO:0000269\|PubMed:10353244, ECO:0000269\|PubMed:10367892	2..31		19/28 (68%)
		HEAT 2. /evidence=ECO:0000269\|PubMed:10353244, ECO:0000269\|PubMed:10367892	33..65		20/31 (65%)
		HEAT 3. /evidence=ECO:0000269\|PubMed:10353244, ECO:0000269\|PubMed:10367892	85..123		18/37 (49%)
		HEAT repeat	128..160	CDD:293787	17/31 (55%)
		HEAT 4. /evidence=ECO:0000269\|PubMed:10353244, ECO:0000269\|PubMed:10367892	129..160		17/30 (57%)
		HEAT repeat	169..200	CDD:293787	22/30 (73%)
		HEAT 5. /evidence=ECO:0000269\|PubMed:10353244, ECO:0000269\|PubMed:10367892	170..202		23/31 (74%)
		HEAT repeat	211..244	CDD:293787	22/32 (69%)
		HEAT 6. /evidence=ECO:0000269\|PubMed:10353244, ECO:0000269\|PubMed:10367892	212..247		24/34 (71%)
		HEAT 7. /evidence=ECO:0000269\|PubMed:10353244, ECO:0000269\|PubMed:10367892	253..302		37/48 (77%)
		HEAT 8. /evidence=ECO:0000269\|PubMed:10353244, ECO:0000269\|PubMed:10367892	314..360		31/45 (69%)
		HEAT repeat	323..354	CDD:293787	19/30 (63%)
		IAB-binding	329..342		9/12 (75%)
		Ran-GTP binding	334..419		61/84 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159496
Domainoid	1	1.000	503	1.000	Domainoid score	I338
eggNOG	1	0.900	-	-		E1_COG5215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1707
Inparanoid	1	1.050	1068	1.000	Inparanoid score	I248
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S954
OMA	1	1.010	-	-		QHG56400
OrthoDB	1	1.010	-	-		D222415at33208
OrthoFinder	1	1.000	-	-		FOG0003173
OrthoInspector	1	1.000	-	-		oto89662
orthoMCL	1	0.900	-	-		OOG6_101642
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R600
SonicParanoid	1	1.000	-	-		X2136
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750