DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and Ranbp6

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_001101054.1	Gene:	Ranbp6 / 309326	RGDID:	1305165	Length:	1105	Species:	Rattus norvegicus

Alignment Length:	970	Identity:	196/970 - (20%)
Similarity:	338/970 - (34%)	Gaps:	327/970 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LEKTVSPDKNELLS-AKNFLE---------QAAASNLPEFLKA---LSEILVNTANSAVARMAAG 64
            |..|:| ||.|... .||.:.         :....|:|...|.   |..:....|...|.:|||.
  Rat     9 LPATIS-DKQEFYQLLKNLINPSCMVRRQAEEVYENIPGLCKTTFLLDAVRNRRAGYEVRQMAAA 72

  Fly    65 LQLKNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVI---- 125
            | |:..|:|..|:|       :...|||::..:|..::.|:..| |..|...:.....||:
  Rat    73 L-LRRLLSSGFEEV-------YPNLPSEVQRDVKIELILAVKLE-THASMRKKLCDIFAVLARNL 128

  Fly   126 --ELPINRWPMLIQTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSN---DVLTAIIH 185
              |...|.||..::.|::.:.|:  :.:..|.||....:..     |:..||..   |::..::.
  Rat   129 IDENGTNHWPEGLKFLIDSIHSK--NVVLWEVALHVFWHFP-----GIFGNQDRHDLDIIKRLLD 186

  Fly   186 GMRKVEPSNH-------VRLAATTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAA 243
              :.::...|       .|.||...|.|...........|:....:..|.....|..||     .
  Rat   187 --QCIQDQEHPAIRTLSARAAAAFVLANENNIALFKDFADLLPGILQAVNDSCYQDDDS-----V 244

  Fly   244 LQCLVKIMTLYYQYMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIE-----S 303
            |:.||:|.....:|:.||:...|    ..::|...|          |.:.:.:..||:|     |
  Rat   245 LESLVEIADTVPKYLGPYLEDTL----QLSLKLCGD----------SRLSNLQRQLALEVIVTLS 295

  Fly   304 QEATDQGRAPQRVSKH--YARGALQFLTPVLV-----EKLTKQDECDDEDTWSPAKAASVCLMVL 361
            :.||..      :.||  ....|:..:..::|     :.....||.:::|..|.|.||...|..|
  Rat   296 ETATPM------LKKHTNIIAQAVPHILAMMVDLQDDDDWVNADEMEEDDFDSNAVAAESALDRL 354

  Fly   362 ATCCEDEIVPHVLPFIKENI----ESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRL 422
            |.....::   |||..||:|    :|.:|:.|.|.:|...::..|.. ..::|::::.:.:::..
  Rat   355 ACGLGGKV---VLPMTKEHIMQMLQSHDWKCRHAGLMALSAIGEGCH-QQMEPILDETVNSVLLF 415

  Fly   423 MYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAA 487
            :.|                                          ..|||.|
  Rat   416 LQD------------------------------------------PHPRVRA------------- 425

  Fly   488 WEAAVTNDGETPETYALS---PYFEYIITQLLETTDRSDGAQANLRCAAYQALMDMIKNSPLDCY 549
              ||.|..|:....:|.|   .:.|.:||.||.|.:.....:...:.|:  ||:..|::.|
  Rat   426 --AACTTLGQMATDFAPSFQKKFHEIVITALLRTMENQGNQRVQSQAAS--ALVIFIEDCP---- 482

  Fly   550 LVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVLRKVHEQDAPQISDAIMT 614
                 .:|:||...|.|                ..|||:|...||.::|           :....
  Rat   483 -----KSLLILYLENMV----------------KSLQSILVIKLQELIR-----------NGTKL 515

  Fly   615 ALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFLVMGLKNFQEYQV------- 672
            ||..:..:.|..:.|: ||.|:....:          :||:.|..:.:.::  :|.::
  Rat   516 ALEQLVTTIASVADVI-EENFIPYYDI----------FMPSLKHVVELAVQ--KELKLLRGKTIE 567

  Fly   673 CCAAVGLTGDIFRALKDLMVPYSNEIMTVL------INNLTEPTIHRTVKPQ---VLSAFGDIAL 728
            |.:.|||.....:.::|     ::.:|.:|      :||:.|.      .||   ::||:..:..
  Rat   568 CISHVGLAVGKEKFMQD-----ASNVMQILLKTQSDLNNMEED------DPQTSYMVSAWARMCK 621

  Fly   729 SIGNHFLPYLSMVLD-MLRVASN------LQT-DANNFDMNE----------------------- 762
            .:|..|..||.:|:: :::.||.      |.| |..|...:|
  Rat   622 ILGKDFEQYLPLVIEPLIKTASAKPDVALLDTQDVENMSDDEGWQFVNLGDQQSFGIKTSGLEAK 686

  Fly   763 ---------YINELRESILEAYT---------------------------------GIIQG---- 781
                     |..||||..:| ||                                 ..|:|
  Rat   687 ATACQMLVYYAKELREGFVE-YTEQVVKMMVPLLKFYFHDNVRMAAAEAMPFLLECARIRGSEYL 750

  Fly   782 -----------LKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGD--VSDSMLASAAGFI 828
                       :|.:.....|||:   ..:|:  ||.|.|...||  ::|..|....|.:
  Rat   751 SQMWQFICDPLIKAIGTEPDTDVL---SEIMN--SFAKSIEVMGDGCLNDEHLEELGGIL 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	194/966 (20%)
		IBN_N	27..107	CDD:281761	22/91 (24%)
		HEAT repeat	136..162	CDD:293787	5/25 (20%)
		HEAT repeat	179..209	CDD:293787	6/36 (17%)
		HEAT repeat	223..255	CDD:293787	8/31 (26%)
		HEAT repeat	264..291	CDD:293787	3/26 (12%)
		HEAT repeat	330..360	CDD:293787	9/34 (26%)
		HEAT repeat	373..401	CDD:293787	11/31 (35%)
		HEAT_EZ	386..441	CDD:290247	7/54 (13%)
		HEAT repeat	414..444	CDD:293787	1/29 (3%)
		HEAT repeat	457..482	CDD:293787	4/24 (17%)
		HEAT repeat	508..540	CDD:293787	9/31 (29%)
Ranbp6	NP_001101054.1	HEAT repeat	330..353	CDD:293787	8/22 (36%)
		HEAT repeat	363..395	CDD:293787	11/31 (35%)
		HEAT_2	371..474	CDD:290374	26/162 (16%)
		HEAT_EZ	380..434	CDD:290247	15/111 (14%)
		HEAT repeat	407..437	CDD:293787	9/86 (10%)
		HEAT repeat	449..476	CDD:293787	8/28 (29%)
		HEAT repeat	502..526	CDD:293787	5/34 (15%)
		HEAT repeat	539..572	CDD:293787	5/44 (11%)
		HEAT repeat	873..898	CDD:293787
		HEAT repeat	910..942	CDD:293787
		HEAT_EZ	927..987	CDD:290247
		HEAT repeat	954..990	CDD:293787
		HEAT repeat	999..1023	CDD:293787
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910