DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and Ipo5

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	XP_006252540.1	Gene:	Ipo5 / 306182	RGDID:	1308715	Length:	1097	Species:	Rattus norvegicus

Alignment Length:	979	Identity:	201/979 - (20%)
Similarity:	340/979 - (34%)	Gaps:	302/979 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKA--LSEILVNTANSAVARMAAGLQLKNH 70
            |...:|...:|||......|:...|     |:|...|.  |.:.:.||..:..||..|.:.|:..
  Rat    10 QFYLLLGNLLSPDNVVRKQAEETYE-----NIPGRSKITFLLQAIRNTTAAEEARQMAAVLLRRL 69

  Fly    71 LTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPS-----C--AAQCVAYVAVIELP 128
            |:|..::|       :...||:::..||:.:|..:..| |:.|     |  ||: :|...:.|..
  Rat    70 LSSAFDEV-------YPALPSDVQTAIKSELLMIIQME-TQSSMRKKICDIAAE-LARNLIDEDG 125

  Fly   129 INRWPMLIQTLVNKVVSEGSSEMHRESALEAIGYICQDIRF-GVMENQSNDVLTAI----IHGMR 188
            .|:||..::.|.:.|.|:...  .||:||....      .| |:..||....|..|    :..|:
  Rat   126 NNQWPEGLKFLFDSVSSQNMG--LREAALHIFW------NFPGIFGNQQQHYLDVIKRMLVQCMQ 182

  Fly   189 KVE-PSNHVRLAATTAL------HNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQC 246
            ..| ||.....|..||.      ||...|  .:| .|:...|:..|.....|..||     .|:.
  Rat   183 DQEHPSIRTLSARATAAFILANEHNVALF--KHF-ADLLPGFLQAVNDSCYQNDDS-----VLKS 239

  Fly   247 LVKIMTLYYQYMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGR 311
            ||:|.....:|:.|::...|    ..::|...|          :|:.:.:..||:| ...|....
  Rat   240 LVEIADTVPKYLRPHLEATL----QLSLKLCGD----------TNLNNMQRQLALE-VIVTLSET 289

  Fly   312 APQRVSKH---YARGALQFLTPVL----VEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEI 369
            |...:.||   .|:...|.|..::    .|.....||.:|:|..|.|.|....|..:|.....::
  Rat   290 AAAMLRKHTNIIAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMACGLGGKL 354

  Fly   370 VPHVLPFIKENI----ESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIV 430
               |||.|||:|    ::.:|::|.|.:|...::
  Rat   355 ---VLPMIKEHIMQMLQNADWKYRHAGLMALSAI------------------------------- 385

  Fly   431 RDTIAWTFGRICDIIPEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTND 495
                    |..|....|..:||.....||  |::.  ..|||....|.|.
  Rat   386 --------GEGCHQQMEGILNEIVNFVLL--FLQD--PHPRVRYAACNAV--------------- 423

  Fly   496 GETPETYA---LSPYFEYIITQLLETTDRSDGAQANLRCAAYQALMDMIKNSPLDCYLVVQRTTL 557
            |:....:|   ...:.|.:|..||:|.:  |.....::..|..||::..::.|
  Rat   424 GQMATDFAPGFQKKFHEKVIAALLQTME--DQGNQRVQAHAAAALINFTEDCP------------ 474

  Fly   558 VILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNS 622
                                        :|||...|.::::.:|         :||...|.....
  Rat   475 ----------------------------KSLLIPYLDNLVKHLH---------SIMVLKLQELIQ 502

  Fly   623 SAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFLVMGLKNFQEYQV-------------CC 674
            ...|  :|.|:...:::::.:....:|..|.    |..:..||:..|..|             |.
  Rat   503 KGTK--LVLEQVVTSIASVADTAEEKFVPYY----DLFMPSLKHIVENAVQKELRLLRGKTIECI 561

  Fly   675 AAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQV---LSAFGDIALSIGNHFLP 736
            :.:||.....:.::|     ::::|.:|:...|:........||:   :||:..:...:|..|..
  Rat   562 SLIGLAVGKEKFMQD-----ASDVMQLLLKTQTDFNDMEDDDPQISYMISAWARMCKILGKEFQQ 621

  Fly   737 YLSMVLDMLRVASNLQTDANNFDMNE--------------------------------------- 762
            ||.:|:..|...::::.:....|..:
  Rat   622 YLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLV 686

  Fly   763 -YINELRESILEAYTGIIQGL----------KGVDQTAHTDVMHMEPHLM--------------- 801
             |..||:|..:| ||..:..|          .|| :.|..:.|   |.|:
  Rat   687 CYAKELKEGFVE-YTEQVVKLMVPLLKFYFHDGV-RVAAAESM---PLLLECARVRGPEYLTQMW 746

  Fly   802 HII--SFIKRIAQEGD---VSDSM--LASAAGFIGDLCTS------FGPRLYPLLDDAIITQFLA 853
            |.:  :.||.|..|.|   :|:.|  .|.....:||.|.:      .|..|...|::....|.|.
  Rat   747 HFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELR 811

  Fly   854 EGKR 857
            :.||
  Rat   812 QVKR 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	199/970 (21%)
		IBN_N	27..107	CDD:281761	20/81 (25%)
		HEAT repeat	136..162	CDD:293787	7/25 (28%)
		HEAT repeat	179..209	CDD:293787	11/40 (28%)
		HEAT repeat	223..255	CDD:293787	9/31 (29%)
		HEAT repeat	264..291	CDD:293787	3/26 (12%)
		HEAT repeat	330..360	CDD:293787	9/33 (27%)
		HEAT repeat	373..401	CDD:293787	11/31 (35%)
		HEAT_EZ	386..441	CDD:290247	5/54 (9%)
		HEAT repeat	414..444	CDD:293787	2/29 (7%)
		HEAT repeat	457..482	CDD:293787	8/24 (33%)
		HEAT repeat	508..540	CDD:293787	9/31 (29%)
Ipo5	XP_006252540.1	KAP95	13..>634	CDD:227540	166/788 (21%)
		HEAT repeat	177..199	CDD:293787	6/21 (29%)
		HEAT repeat	217..245	CDD:293787	9/32 (28%)
		HEAT repeat	257..298	CDD:293787	10/55 (18%)
		Importin_rep_4	268..357	CDD:408579	23/102 (23%)
		HEAT repeat	355..387	CDD:293787	11/70 (16%)
		HEAT repeat	399..429	CDD:293787	10/48 (21%)
		HEAT repeat	441..468	CDD:293787	8/28 (29%)
		HEAT repeat	482..519	CDD:293787	8/47 (17%)
		HEAT repeat	531..564	CDD:293787	6/36 (17%)
		Importin_rep_6	765..874	CDD:408599	13/51 (25%)
		HEAT repeat	865..890	CDD:293787
		HEAT repeat	903..936	CDD:293787
		HEAT_EZ	921..966	CDD:404407
		HEAT repeat	946..982	CDD:293787
		HEAT repeat	991..1015	CDD:293787
		Importin_rep_5	1005..1051	CDD:408587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910