DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and Ipo4

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_001099508.1	Gene:	Ipo4 / 290228	RGDID:	1305206	Length:	1081	Species:	Rattus norvegicus

Alignment Length:	1026	Identity:	212/1026 - (20%)
Similarity:	338/1026 - (32%)	Gaps:	324/1026 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHLTSKDE 76
            ||::.:.||...:..|...|:.|...  |..|.||.::|.:..:..:.:.||.|
  Rat     9 ILKELLMPDTERIRRATEQLQTALRD--PAALPALCDLLASATDPQIRQFAAVL----------- 60

  Fly    77 KVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAV----IELPINR------ 131
             ..::..:||.:...|.||.:|:.:|.||..|...         ||:|    :...|.|
  Rat    61 -TRRRLSNRWRRLAPEQRESLKSLVLTALQKETEH---------YVSVSLAQLSATIFRKEGLQG 115

  Fly   132 WPMLIQTLVNKVVSEGSSE--------------------MHRESALEAIGYICQDIRFGVMENQS 176
            ||..:..|.:...|..|.|                    .|::..|:.:.....::.|..:...|
  Rat   116 WPQFMNLLQHSTHSAHSPEKEVGLLLLSVVVSSQPEAFHAHQQELLQLLIETLSEVSFPGVLFYS 180

  Fly   177 NDVLTA-------------------IIHGMRKVEPSNHVRLA-ATTALHNSLEFTKSNFEKDMER 221
            ...|||                   ::..:|.:.|.:.|:.. |..||...||     .|..:..
  Rat   181 LRTLTALARYLRPDDVSLARMLVPKVVTALRTLIPLDEVKACEALEALDEMLE-----TELPIIT 240

  Fly   222 NFIMEVVCEATQCQD--------SQICVAALQCL-----VKIMTLYYQYMEPYMAQALFPITLAA 273
            ..:.||:   |.|.:        ..|.|..|.||     ||...|....:.|.:..|||||..|.
  Rat   241 PHLSEVL---TFCLEVAKNVALGEAIRVRILCCLTFLVKVKSKALLKNRLLPPLLNALFPIMAAE 302

  Fly   274 ----------MKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFL 328
                      ..||:|              |.||.|         .|..|    ||:|...:..|
  Rat   303 PPLGQLDPEDQDSDDD--------------DLEIGL---------MGETP----KHFAVQVVDML 340

  Fly   329 T-------------PVLVEKLTKQDECDDEDTWSP--AKAASVCLMVLATCCEDEIVPHVL-PFI 377
            .             |:|.|.|..:         :|  .||..:.|.||:....|.|...:| |.:
  Rat   341 ALHLPPEKLCPHVMPMLEEALRSE---------APYQRKAGFLVLAVLSDGAGDHIRQRLLYPLL 396

  Fly   378 K---ENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFG 439
            :   :.::.|:...|:||:...|.....|:.: :....|:.||.|  |.|..||.:.:|  ....
  Rat   397 QIVCKGLDDPSQVVRNAALFALGQFSENLQPH-ISSYSEEVMPLL--LTYLKSVPMGNT--HHLA 456

  Fly   440 RICDIIPEAAIN-----ETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDG--E 497
            :.|..:.....|     :.||..|:||.::.||:..:....             |.||:..|  .
  Rat   457 KACYALENFVENLGPKVQPYLPELMECMLQPLKNPSKARTK-------------ELAVSAIGAIA 508

  Fly   498 TPETYALSPYF--------EYIIT----------QLLETTDRSDGAQANLRCAAYQALMDMIKNS 544
            |....:|.|||        |:::|          |.|||.    |..|       :||.:.:|..
  Rat   509 TAAQDSLLPYFPTVMEHIREFLLTGHDDLHLVQIQSLETL----GVLA-------RALGESMKPL 562

  Fly   545 PLDCYLV------------VQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVL 597
            ..:|..:            |:|.|..:...|:.:|       ..|.......:.:|:..:|:|.
  Rat   563 AEECCQLGLGLCIHVDDPDVRRCTYSLFAALSGLM-------GESLGPYLPQITTLMLLSLRST- 619

  Fly   598 RKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFLVM 662
                |...||. |.|.:.||...:|.|.:...:.:|.........|:.|.....   ||
  Rat   620 ----EGIVPQY-DGISSFLLFEDDSEAEEEEELMDEDMEEEEDDSEISGYSVEN---AF------ 670

  Fly   663 GLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVLSAFGDIA 727
                |.|.:..|.|:   |:|........:|:.:.|...:...|..|  |..|:.....|.|...
  Rat   671 ----FDEKEDTCTAL---GEISMNTSVAFLPFMDAIFDEVYKLLECP--HMNVRKAAYEALGQFC 726

  Fly   728 LSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEA---------YTGIIQGLK 783
            .::  |            :......:|.||..:...:.....|.::|         ...:::.|.
  Rat   727 CAL--H------------KACQRGPSDPNNAALQSSLARAIPSYMQAVKVERERPVVMAVLEALT 777

  Fly   784 GVDQTAHTDVMHMEPHLMHIISFIKRI---------AQEGDVSDS------------------ML 821
            ||.:|.....:.....|..:.:.:|.:         |:|.|..|.                  :|
  Rat   778 GVLRTCGALTLQPPGRLSELCNVLKAVLQKKTACQDAEEDDDEDDDQAEYDAMLLEHAGEAIPVL 842

  Fly   822 ASAAGFIGDLCTSFGPRLYPLLDDAIITQFLAEGKRSKAQRTKMLCTWAVK 872
            |:|||  |.....|.....|||                ..:||..||.|.|
  Rat   843 AAAAG--GHAFAPFFATFLPLL----------------LCKTKQSCTVAEK 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	210/1021 (21%)
		IBN_N	27..107	CDD:281761	20/79 (25%)
		HEAT repeat	136..162	CDD:293787	6/45 (13%)
		HEAT repeat	179..209	CDD:293787	9/49 (18%)
		HEAT repeat	223..255	CDD:293787	12/44 (27%)
		HEAT repeat	264..291	CDD:293787	9/36 (25%)
		HEAT repeat	330..360	CDD:293787	8/31 (26%)
		HEAT repeat	373..401	CDD:293787	7/31 (23%)
		HEAT_EZ	386..441	CDD:290247	14/54 (26%)
		HEAT repeat	414..444	CDD:293787	9/29 (31%)
		HEAT repeat	457..482	CDD:293787	5/24 (21%)
		HEAT repeat	508..540	CDD:293787	11/49 (22%)
Ipo4	NP_001099508.1	KAP95	1..>620	CDD:227540	152/718 (21%)
		IBN_N	24..90	CDD:197981	20/79 (25%)
		HEAT repeat	353..381	CDD:293787	10/36 (28%)
		HEAT repeat	394..424	CDD:293787	6/29 (21%)
		HEAT	395..425	CDD:281045	5/29 (17%)
		HEAT repeat	435..464	CDD:293787	9/32 (28%)
		HEAT repeat	477..507	CDD:293787	10/42 (24%)
		HEAT repeat	666..688	CDD:293787	8/37 (22%)
		HEAT repeat	698..726	CDD:293787	7/29 (24%)
		HEAT repeat	900..928	CDD:293787
		HEAT repeat	941..971	CDD:293787
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910