DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and kap95

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_594233.1	Gene:	kap95 / 2542496	PomBaseID:	SPAC1B1.03c	Length:	863	Species:	Schizosaccharomyces pombe

Alignment Length:	875	Identity:	353/875 - (40%)
Similarity:	510/875 - (58%)	Gaps:	33/875 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHLTSKDEK 77
            |.:|:|||.|..|:|:..||.||.::..:::..|::.|.|..:....||||||.|||.:|:::|.
pombe     7 LAQTLSPDANVRLNAEKQLENAARTDFAQYMVLLAQELANDNSMPYIRMAAGLALKNAITAREEA 71

  Fly    78 VSQQYQDRWHQFPSEIRELIKNNILAALG-TENTRPSCAAQCVAYVAVIELPINRWPMLIQTLVN 141
            ...:||..|...|.||::.:|:..|..|| :|:.....|||.||.:|..||..|:||.|:.|||.
pombe    72 RKLEYQQLWQSLPVEIKQQVKSLALQTLGSSEHQAGQSAAQLVAAIAAYELATNQWPDLMVTLVA 136

  Fly   142 KVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAATTALHN 206
            . |.||.....::.:|:.|||||:.:...|:..|||.:|||::.|.||.||...|||||..||::
pombe   137 N-VGEGQPSALKQHSLQTIGYICESVSPEVLSAQSNAILTAVVAGARKEEPDAAVRLAALGALYD 200

  Fly   207 SLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQALFPITL 271
            ||||.:.||..:.|||:||:|||||||..::.|..||..||||||.|||..|..||.:|||.:|.
pombe   201 SLEFVRENFNNEYERNYIMQVVCEATQSPEASIQTAAFGCLVKIMHLYYDTMPFYMEKALFALTT 265

  Fly   272 AAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVEKL 336
            ..|.:.|:.||||.:||||.||:|||::.:|.|||.|....|.|.:..:||.|...:.|||::.|
pombe   266 QGMYNTNEQVALQAVEFWSTVCEEEIEVNLEIQEAQDLNEVPARQNHGFARAAAADILPVLLKLL 330

  Fly   337 TKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLN 401
            ..|||..|||.|:.:.||:.||.:.|....|.||..||.|:::||::|:|..|:||||.|||||.
pombe   331 CNQDEDADEDDWNISMAAATCLQLFAQVVGDLIVNPVLAFVEQNIQNPDWHQREAAVMAFGSVLE 395

  Fly   402 GLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLECFVKSL 466
            |.....|.|||.||:|.||.:|.|..:.|:||.||..|:|...:.:|...|.:|..::...::.|
pombe   396 GPNVAMLTPLVNQALPVLINMMVDPVIFVKDTTAWALGQISSFVADAINPEIHLSPMVSALLQGL 460

  Fly   467 KSEPRVAANVCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLLETTDRSDGAQANLRC 531
            ...||:.||.||||:.|  ....|.|.|.    :|..::|::|.||..||..||:. |.:.|.|.
pombe   461 TDNPRIVANCCWAFMNL--VCHFAPVDNH----QTSVMTPFYEAIIGSLLHVTDQK-GNENNSRT 518

  Fly   532 AAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSV 596
            :.|:.|..:|..|......::.....:||.||...:||::||.:..||...::|||.||..|.|:
pombe   519 SGYETLGTLITFSSDSVLPMIANVLSIILTRLETSIQMQSQILDVEDRANHDELQSNLCNVLTSI 583

  Fly   597 LRKVHEQDAPQI---SDAIMTALL-TMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFK 657
            :|:.    .|.|   ||.||..|| ||  .:|.|..||.|:..||:..::..|..||..|:|:|.
pombe   584 IRRF----GPDIRTSSDQIMNLLLQTM--QTAPKQSVVHEDVLLAIGAMMNSLEEQFEVYVPSFV 642

  Fly   658 DFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVLSA 722
            .||...|.|.||||:|..||||.||:.|||...::||.::.||.|:.:|....:.|.|||.:||.
pombe   643 PFLSSALSNEQEYQLCSVAVGLVGDLARALNAKILPYCDDFMTRLVQDLQSSVLDRNVKPAILSC 707

  Fly   723 FGDIALSIGNHFLPYLSMVLDMLRVASNLQTDAN-NFDMNEYINELRESILEAYTGIIQGLKGVD 786
            |.||||:||..|..||..|:.:|:.||::|.... ||.|.:|::.||..|:|||.||.|.::
pombe   708 FSDIALAIGAAFQTYLEAVMVLLQQASSVQAPPGANFSMIDYVDALRLGIVEAYVGITQAVR--- 769

  Fly   787 QTAHTD--VMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPR--LYPLLDDAI 847
                ||  :..::|::..:.:.:..|..:.:.|:|:..:|.|.:|||..|| |:  |........
pombe   770 ----TDNRLDLIQPYVHSMFTLLNMITADPECSESLTRAALGLLGDLAESF-PKGELKSYFAADW 829

  Fly   848 ITQFLAEGK-RSKAQRTKMLCTWAVKEIKK 876
            :...|..|| :..:|:||.|..||.:::|:
pombe   830 VAALLNSGKTKISSQQTKDLARWATEQVKR 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	350/869 (40%)
		IBN_N	27..107	CDD:281761	29/80 (36%)
		HEAT repeat	136..162	CDD:293787	8/25 (32%)
		HEAT repeat	179..209	CDD:293787	16/29 (55%)
		HEAT repeat	223..255	CDD:293787	19/31 (61%)
		HEAT repeat	264..291	CDD:293787	13/26 (50%)
		HEAT repeat	330..360	CDD:293787	15/29 (52%)
		HEAT repeat	373..401	CDD:293787	16/27 (59%)
		HEAT_EZ	386..441	CDD:290247	29/54 (54%)
		HEAT repeat	414..444	CDD:293787	14/29 (48%)
		HEAT repeat	457..482	CDD:293787	9/24 (38%)
		HEAT repeat	508..540	CDD:293787	12/31 (39%)
kap95	NP_594233.1	KAP95	1..863	CDD:227540	353/875 (40%)
		IBN_N	21..101	CDD:281761	28/79 (35%)
		HEAT repeat	42..63	CDD:293787	9/20 (45%)
		HEAT repeat	75..104	CDD:293787	10/28 (36%)
		HEAT repeat	114..160	CDD:293787	21/46 (46%)
		HEAT repeat	169..204	CDD:293787	20/34 (59%)
		HEAT repeat	215..244	CDD:293787	17/28 (61%)
		HEAT repeat	323..354	CDD:293787	15/30 (50%)
		HEAT repeat	367..395	CDD:293787	16/27 (59%)
		HEAT_EZ	380..435	CDD:290247	29/54 (54%)
		HEAT repeat	408..438	CDD:293787	14/29 (48%)
		ARM	409..>480	CDD:237987	26/72 (36%)
		HEAT repeat	451..476	CDD:293787	9/24 (38%)
		HEAT repeat	496..527	CDD:293787	12/31 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	245	1.000	Domainoid score	I425
eggNOG	1	0.900	-	-		E1_COG5215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1707
Inparanoid	1	1.050	590	1.000	Inparanoid score	I162
OMA	1	1.010	-	-		QHG56400
OrthoFinder	1	1.000	-	-		FOG0003173
OrthoInspector	1	1.000	-	-		oto101107
orthoMCL	1	0.900	-	-		OOG6_101642
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R600
SonicParanoid	1	1.000	-	-		X2136
TreeFam	1	0.960	-	-
	14	13.860