DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and imb-1

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_491477.2	Gene:	imb-1 / 172110	WormBaseID:	WBGene00002075	Length:	896	Species:	Caenorhabditis elegans

Alignment Length:	895	Identity:	409/895 - (45%)
Similarity:	574/895 - (64%)	Gaps:	31/895 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTSDIAMQLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGL 65
            |....|.|::.:||||||.::|:...|.:::..|...:.|.|::.||.||......:..|.||||
Worm     1 MAEQAAEQMLTVLEKTVSQNQNDQKQAMDYIAAACQQDFPVFVQCLSMILRTQQCQSFVRQAAGL 65

  Fly    66 QLKNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPIN 130
            ||||.|.:|:.:....|..||.|..:|:||.:|.|:...||||.:|||.||||||.:|..|||.|
Worm    66 QLKNVLCAKETETKNVYLQRWLQLTAEVREQVKQNVTGTLGTEPSRPSIAAQCVAAIACAELPQN 130

  Fly   131 RWPMLIQTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNH 195
            .||.:|..|.:.|....|.||.:||:||.:|||||||...|:|.::||||||||||||..|.|.:
Worm   131 LWPNVINLLKSNVTESQSGEMLKESSLETLGYICQDIDPRVLETKANDVLTAIIHGMRPEESSAN 195

  Fly   196 VRLAATTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEP 260
            ||.|||.||.||||||.:||..:.|||.||:||||:|...|.::.||||||||:||.|||::|..
Worm   196 VRFAATNALLNSLEFTNTNFSNEAERNIIMQVVCESTSSSDQRVKVAALQCLVRIMQLYYEHMLS 260

  Fly   261 YMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRA-PQRVSKHYARGA 324
            ||..|||.|||:||||....||:||:||||.|.:||.||.:..::..::|.. |:..|..:...|
Worm   261 YMGSALFQITLSAMKSQEPEVAMQGMEFWSTVAEEEFDLYMTYEDEVERGAPNPKCASLRFMEQA 325

  Fly   325 LQFLTPVLVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFR 389
            ...:.|||:|.:...|:.||:|.|:|||||.||||:.|.|..|:||.||:||.| :.::|:|:::
Worm   326 ASHVCPVLLEAMAHHDDGDDDDDWTPAKAAGVCLMLAAQCVRDDIVNHVIPFFK-HFQNPDWKYK 389

  Fly   390 DAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETY 454
            :||:|.|||:|:|.:...|.|:.::|:|.::..|.|.:|.||||.||:.||:.|...|.|.|...
Worm   390 EAAIMAFGSILDGPDPKKLLPMAQEALPAIVAAMCDKNVNVRDTAAWSLGRVIDTCSELANNAEL 454

  Fly   455 LQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTN--DGE-TPETYALSPYFEYIITQLL 516
            ||::|......|..|||||.|||||.:.|..|.:|:||.|  ||. .|:|:|||..|:.::.:|:
Worm   455 LQSVLPVLSNGLHQEPRVANNVCWALVSLVKACYESAVANGTDGSGQPDTFALSSVFDPMVGELI 519

  Fly   517 ETTDRSDGAQANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQ 581
            :.|||.||.|:|||..||:|||::||:||.|||..|:.||:|||::|..::|||:|..:.:|:.|
Worm   520 KITDRVDGNQSNLRITAYEALMELIKHSPKDCYSAVRNTTVVILKKLESLLQMESQATSEADKAQ 584

  Fly   582 FNDLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFN-SSAGKSGVVQEEAFLAVSTLVELL 645
            ..|||::||||||||.||:...|.|.:.:.||..|..:.| ::|.:|..|.|||.|||:.|.|.|
Worm   585 VRDLQAMLCATLQSVTRKMQPADIPAVGEHIMNGLYQIMNRAAATRSNAVMEEALLAVACLAEHL 649

  Fly   646 GAQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPT 710
            |..|..||...|.:|:.||.|..|.|||.|||||..|:.|||:..::|:.:|::..||..|..|.
Worm   650 GKGFLSYMNVLKPYLLEGLSNTDETQVCAAAVGLVTDLSRALEAEIMPFMDELIQKLILCLQSPR 714

  Fly   711 IHRTVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASN--LQTDANNFDMNEYINELRESILE 773
            :.|.||..::..|.|||::|..||..|:..|:.:|..|.|  :.||.|:.|..:|::.|||:.|.
Worm   715 LDRNVKVVIIGTFADIAMAIEAHFERYVGSVVPILNNAQNAAVVTDPNDDDQVDYVDRLREACLN 779

  Fly   774 AYTGIIQGLKGV-DQTAHTDVMH--MEPHLMHIISFIKRIAQEGDV--SDSMLASAAGFIGDLCT 833
            :|||||||||.: |.||..::::  :||    |:..|.||:....|  |::::|:.||.||||.
Worm   780 SYTGIIQGLKAIPDTTAARNMINVFVEP----IVQLITRISSMEPVPPSEALIATTAGIIGDLV- 839

  Fly   834 SFGPRLYP-------LLDDAIITQFLAEGKRSKAQRTKMLCTWAVKEIKK 876
                :||.       |.|:  :||.|.:|::||..:||.:..||.|||||
Worm   840 ----QLYEGDIIRFFLTDN--VTQMLQKGRKSKVSKTKSMANWATKEIKK 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	400/877 (46%)
		IBN_N	27..107	CDD:281761	29/79 (37%)
		HEAT repeat	136..162	CDD:293787	10/25 (40%)
		HEAT repeat	179..209	CDD:293787	21/29 (72%)
		HEAT repeat	223..255	CDD:293787	19/31 (61%)
		HEAT repeat	264..291	CDD:293787	17/26 (65%)
		HEAT repeat	330..360	CDD:293787	17/29 (59%)
		HEAT repeat	373..401	CDD:293787	12/27 (44%)
		HEAT_EZ	386..441	CDD:290247	23/54 (43%)
		HEAT repeat	414..444	CDD:293787	13/29 (45%)
		HEAT repeat	457..482	CDD:293787	12/24 (50%)
		HEAT repeat	508..540	CDD:293787	16/31 (52%)
imb-1	NP_491477.2	KAP95	17..883	CDD:227540	400/877 (46%)
		HEAT repeat	331..361	CDD:293787	17/29 (59%)
		HEAT repeat	374..401	CDD:293787	12/27 (44%)
		HEAT repeat	414..448	CDD:293787	14/33 (42%)
		HEAT repeat	457..482	CDD:293787	12/24 (50%)
		HEAT repeat	515..543	CDD:293787	15/27 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167083
Domainoid	1	1.000	331	1.000	Domainoid score	I607
eggNOG	1	0.900	-	-		E1_COG5215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1707
Inparanoid	1	1.050	750	1.000	Inparanoid score	I293
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S954
OMA	1	1.010	-	-		QHG56400
OrthoDB	1	1.010	-	-		D222415at33208
OrthoFinder	1	1.000	-	-		FOG0003173
OrthoInspector	1	1.000	-	-		oto19951
orthoMCL	1	0.900	-	-		OOG6_101642
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R600
SonicParanoid	1	1.000	-	-		X2136
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790