DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and Kpnb1

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_032405.3	Gene:	Kpnb1 / 16211	MGIID:	107532	Length:	876	Species:	Mus musculus

Alignment Length:	876	Identity:	541/876 - (61%)
Similarity:	677/876 - (77%)	Gaps:	3/876 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MQLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHL 71
            |:||.|||||||||:.||.:|:.|||:||..|||.||..||.:|.|..||.|||:|||||:||.|
Mouse     1 MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSL 65

  Fly    72 TSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPINRWPMLI 136
            ||||..:..|||.||....:..|..:||.:|..||||..|||.|:||||.:|..|:|:::||.||
Mouse    66 TSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAEIPVSQWPELI 130

  Fly   137 QTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAAT 201
            ..||..|.:..|:|..:||.|||||||||||....::::||::|||||.||||.||||:|:||||
Mouse   131 PQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAAT 195

  Fly   202 TALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQAL 266
            .||.|||||||:||:|:.||:|||:||||||||.|:::.|||||.|||||:|||||||.||..||
Mouse   196 NALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPAL 260

  Fly   267 FPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPV 331
            |.||:.|||||.|.||||||||||||||||:|||||:.||.:|||.|:..||.||:||||:|.|:
Mouse   261 FAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPI 325

  Fly   332 LVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTF 396
            |.:.||||||.||:|.|:|.|||.||||:|:|||||:|||||||||||:|::|:||:||||||.|
Mouse   326 LTQTLTKQDENDDDDDWNPCKAAGVCLMLLSTCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAF 390

  Fly   397 GSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLEC 461
            ||:|.|.|.|.|||||.|||||||.||.|.||:||||.|||.||||:::||||||:.||..||:|
Mouse   391 GSILEGPEPNQLKPLVIQAMPTLIELMKDPSVVVRDTTAWTVGRICELLPEAAINDVYLAPLLQC 455

  Fly   462 FVKSLKSEPRVAANVCWAFIGLSDAAWEAA-VTNDGETPETYALSPYFEYIITQLLETTDRSDGA 525
            .::.|.:|||||:||||||..|::||:||| |.:|.|.|.||.||..||.|:.:|||||||.||.
Mouse   456 LIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGH 520

  Fly   526 QANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLC 590
            |.|||.:||::||:::|||..|||..||:|||||:|||.||:|||:.|.:.|||.||||||||||
Mouse   521 QNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLC 585

  Fly   591 ATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPA 655
            ||||:|||||..|||.||||.:|.:||.||.|:|| ||.|||:|.:|||||||:||.:|.|||.|
Mouse   586 ATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAG-SGGVQEDALMAVSTLVEVLGGEFLKYMEA 649

  Fly   656 FKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVL 720
            ||.||.:||||:.|||||.|||||.||:.|||:..::|:.:|:|.:|:.||....:||:||||:|
Mouse   650 FKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNILPFCDEVMQLLLENLGNENVHRSVKPQIL 714

  Fly   721 SAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGLKGV 785
            |.||||||:||..|..||.:||:.|:.||..|.|.::|||.:|:||||||.|||||||:|||||.
Mouse   715 SVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDFDMVDYLNELRESCLEAYTGIVQGLKGD 779

  Fly   786 DQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPRLYPLLD-DAIIT 849
            .:..|.|||.::|.:..|:|||..||.:.|.:|.::|.|||.||||||:||..:..|:: ..:|.
Mouse   780 QENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIH 844

  Fly   850 QFLAEGKRSKAQRTKMLCTWAVKEIKKINTQ 880
            :.|.||:|||..:.|.|.|||.||::|:..|
Mouse   845 ELLTEGRRSKTNKAKTLATWATKELRKLKNQ 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	531/860 (62%)
		IBN_N	27..107	CDD:281761	42/79 (53%)
		HEAT repeat	136..162	CDD:293787	12/25 (48%)
		HEAT repeat	179..209	CDD:293787	22/29 (76%)
		HEAT repeat	223..255	CDD:293787	23/31 (74%)
		HEAT repeat	264..291	CDD:293787	20/26 (77%)
		HEAT repeat	330..360	CDD:293787	19/29 (66%)
		HEAT repeat	373..401	CDD:293787	20/27 (74%)
		HEAT_EZ	386..441	CDD:290247	40/54 (74%)
		HEAT repeat	414..444	CDD:293787	23/29 (79%)
		HEAT repeat	457..482	CDD:293787	15/24 (63%)
		HEAT repeat	508..540	CDD:293787	20/31 (65%)
Kpnb1	NP_032405.3	KAP95	2..871	CDD:227540	538/869 (62%)
		HEAT 1. /evidence=ECO:0000269\|PubMed:10964573	3..29		17/25 (68%)
		HEAT 2. /evidence=ECO:0000269\|PubMed:10964573	32..62		19/29 (66%)
		HEAT 3. /evidence=ECO:0000269\|PubMed:10964573	85..120		17/34 (50%)
		HEAT repeat	128..160	CDD:293787	17/31 (55%)
		HEAT 4. /evidence=ECO:0000269\|PubMed:10964573	129..160		17/30 (57%)
		HEAT repeat	169..200	CDD:293787	22/30 (73%)
		HEAT 5. /evidence=ECO:0000269\|PubMed:10964573	170..201		22/30 (73%)
		HEAT repeat	211..244	CDD:293787	22/32 (69%)
		HEAT 6. /evidence=ECO:0000269\|PubMed:10964573	212..247		24/34 (71%)
		HEAT 7. /evidence=ECO:0000269\|PubMed:10964573	260..302		33/41 (80%)
		HEAT 8. /evidence=ECO:0000269\|PubMed:10964573	314..359		29/44 (66%)
		HEAT repeat	323..354	CDD:293787	19/30 (63%)
		IAB-binding	329..342		9/12 (75%)
		Ran-GTP binding. /evidence=ECO:0000250	334..419		62/84 (74%)
		HEAT repeat	367..395	CDD:293787	20/27 (74%)
		HEAT 10. /evidence=ECO:0000269\|PubMed:10964573	399..438		29/38 (76%)
		HEAT repeat	408..438	CDD:293787	23/29 (79%)
		HEAT 11. /evidence=ECO:0000269\|PubMed:14645851	449..485		20/35 (57%)
		HEAT repeat	451..476	CDD:293787	15/24 (63%)
		HEAT 12. /evidence=ECO:0000269\|PubMed:14645851	500..537		21/36 (58%)
		HEAT repeat	503..535	CDD:293787	20/31 (65%)
		HEAT 13. /evidence=ECO:0000269\|PubMed:14645851	544..592		34/47 (72%)
		HEAT 14. /evidence=ECO:0000269\|PubMed:14645851	597..639		28/42 (67%)
		HEAT 15. /evidence=ECO:0000269\|PubMed:14645851	644..680		24/35 (69%)
		HEAT 16. /evidence=ECO:0000269\|PubMed:14645851	686..724		20/37 (54%)
		HEAT 17. /evidence=ECO:0000269\|PubMed:14645851	729..777		28/47 (60%)
		HEAT 18. /evidence=ECO:0000269\|PubMed:14645851	785..828		21/42 (50%)
		HEAT 19. /evidence=ECO:0000269\|PubMed:14645851	834..875		16/40 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849869
Domainoid	1	1.000	502	1.000	Domainoid score	I342
eggNOG	1	0.900	-	-		E1_COG5215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1707
Inparanoid	1	1.050	1065	1.000	Inparanoid score	I251
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S954
OMA	1	1.010	-	-		QHG56400
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003173
OrthoInspector	1	1.000	-	-		oto93229
orthoMCL	1	0.900	-	-		OOG6_101642
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R600
SonicParanoid	1	1.000	-	-		X2136
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740