DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fs(2)Ket and AgaP_AGAP006942

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	XP_308814.4	Gene:	AgaP_AGAP006942 / 1270142	VectorBaseID:	AGAP006942	Length:	1097	Species:	Anopheles gambiae

Alignment Length:	972	Identity:	195/972 - (20%)
Similarity:	343/972 - (35%)	Gaps:	225/972 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LEKTVSPDKNELLSAKNFLEQAAAS-----NLPEFLKALSEILVNTANSAVARMAAGLQLKNHLT 72
            :|:|:   ||.|::..:.::||.|.     ..||.:..|.||.|...:..|.:.||.| ||.||.
Mosquito     1 MEQTI---KNLLVADNDLIQQATAELKEAFKKPETIPQLCEICVTNTDPQVRQYAAML-LKKHLG 61

  Fly    73 SKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVI------------ 125
            .         ...|.:.|:|.:.|||..:|.|:..|:.: |.......:|.|:
Mosquito    62 K---------LRAWREVPAETQALIKKGMLEAIVNESEK-SVRNAITGFVGVLVKHEAEKEDGWM 116

  Fly   126 --------ELPINRWPMLIQ---TLVNKVVSEGSSEM--HRE----------SALEAIGYICQDI 167
                    |...:..|.|.:   ::.|.:......:.  |.|          :|.||.|.:...:
Mosquito   117 GEVLKFMFESTSSSDPKLSELGSSVFNTLTDVAPDQFMPHIEMVCQLFSTALTATEASGNMATPV 181

  Fly   168 RFGVMENQSNDVLTAIIHGMRKVEPSNH------VRLAATTALHNSLEFTKS-----NFEKDMER 221
            .:.::...|:  |...|.|.:::|.:..      ::..:..|..:|.:|.::     |...:..|
Mosquito   182 IYNILLGMSH--LVPFIPGRQEIEQTYQDSIPYVLKALSAFAEQDSYKFIEAFDILENLADESSR 244

  Fly   222 ----------NFIMEVVCEATQCQDSQ-----ICVAALQCLVKIMTLYYQYMEPYMAQALFPITL 271
                      :|.:::... ||..||.     ..:..|..|.|.|.:..:.:|| :..|||  ||
Mosquito   245 TLSPHMKLLIDFCLQMAGN-TQLDDSVRVKTITFIGWLVRLKKKMIIKQKLVEP-IVNALF--TL 305

  Fly   272 AAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVS--------KHYARGALQFL 328
            .::..|              |.||:.:....::.:|....|.|.:.        |......:..|
Mosquito   306 MSVAPD--------------VEDEDEEYFGSNEVSTPSTCATQSLDVLALHIPPKQLFPPLMALL 356

  Fly   329 TPVLVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVL----PFIKENIESPNWRFR 389
            .|.|.           .|...|.|||.:.:.|:|..|.:.|....|    ..||..|...|...|
Mosquito   357 EPALA-----------GDNPLPKKAAYLSIAVIAEGCSEHICSKYLRVLVDVIKRGITDENVMIR 410

  Fly   390 DAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVR---------DTIAWTFGRICDII 445
            :||:...|.....|:.. :....::.:|.|...:....:.:|         |.:.:.....|:.:
Mosquito   411 NAALFALGQFSEHLQPE-ISQHADEILPILFEFLQQLCLQIRSGGKEPPHIDRVFYALETTCENL 474

  Fly   446 PEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEY 510
            .:..  ..||..|:|...:||.:...|....    :.|:..|..|:...:       .:.|||..
Mosquito   475 EDQV--TPYLPMLMERLFESLDTRNSVHLRE----LSLTTIAATASAAKE-------HMLPYFPR 526

  Fly   511 IITQL---LETTDRSDGAQANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQ 572
            :|..|   |..||..|  ...||..|......:::....|.:|.      :.::.||..:.|..:
Mosquito   527 LIDCLKLYLVKTDDED--ICTLRPQAIDTFAALVRTIGKDNFLP------LAVDTLNMGLTMMDE 583

  Fly   573 INNHSDRHQ-FN-----------DLQSLLCATLQSVLRKVHEQD--APQISDAIMTALLTMFNSS 623
            .|:...|.. :|           |:...|...::::|..|...:  .|...:.....:..:.|.:
Mosquito   584 SNDPDLRRSCYNLFASMASSVKEDMSGSLNKIVETMLESVRSSEGIVPTFKEGAGDDMAILANGA 648

  Fly   624 -AGKSGV-------------------------------------VQEEAFLAVSTLVELLGAQFA 650
             ||.:|.                                     .:|||.||:....|..|..||
Mosquito   649 LAGTNGSGDGDDEDEEFDIENSVGDEEEDEEDIAGYSIENAYMDEKEEAILALMEFAEHTGPAFA 713

  Fly   651 KYM-PAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDL-MVPYSNEIMTVLINNLTE---PT 710
            .:: .||::  :..|.|.....:..|::........||..| .:...::.:.:|:..|:|   ..
Mosquito   714 PFIQTAFEE--IYKLLNHPNEDIRKASIDAVKQFVVALHQLGNMEGVHQTILILVPKLSEIIRTD 776

  Fly   711 IHRTVKPQVLSAFGDIALSIGNHFL-------PYLSMVLDMLRVASNLQTDANNFDMNEYINELR 768
            ..|||....|..|.||...:|....       ...:.::|:|......|.| ...|..:..:|..
Mosquito   777 EERTVVMSALDGFSDILQEVGAATFQADGQKDAVFNCIVDVLNGKVACQFD-EPVDEEQEESEYD 840

  Fly   769 ESILEAYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGD 830
            |:|||: .|.|....|....|....::......:.|..|::..|:.:.|||..|.|.|.:.:
Mosquito   841 EAILES-AGDILPKFGRALPAEEFAVYFGRVWPYFIQKIEKTKQKDETSDSQRAFAIGVLAE 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	193/968 (20%)
		IBN_N	27..107	CDD:281761	25/84 (30%)
		HEAT repeat	136..162	CDD:293787	6/40 (15%)
		HEAT repeat	179..209	CDD:293787	6/35 (17%)
		HEAT repeat	223..255	CDD:293787	9/36 (25%)
		HEAT repeat	264..291	CDD:293787	6/26 (23%)
		HEAT repeat	330..360	CDD:293787	7/29 (24%)
		HEAT repeat	373..401	CDD:293787	9/31 (29%)
		HEAT_EZ	386..441	CDD:290247	9/63 (14%)
		HEAT repeat	414..444	CDD:293787	5/38 (13%)
		HEAT repeat	457..482	CDD:293787	5/24 (21%)
		HEAT repeat	508..540	CDD:293787	10/34 (29%)
AgaP_AGAP006942	XP_308814.4	IBN_N	19..87	CDD:197981	24/77 (31%)
		HEAT repeat	249..288	CDD:293787	8/39 (21%)
		HEAT repeat	352..380	CDD:293787	9/38 (24%)
		HEAT repeat	393..423	CDD:293787	8/29 (28%)
		HEAT repeat	434..469	CDD:293787	4/34 (12%)
		HEAT_EZ	694..745	CDD:290247	14/52 (27%)
		HEAT repeat	718..755	CDD:293787	8/38 (21%)
		HEAT repeat	764..791	CDD:293787	8/26 (31%)
		HEAT repeat	874..901	CDD:293787	9/26 (35%)
		HEAT repeat	916..946	CDD:293787
		HEAT	917..946	CDD:281045
		HEAT repeat	957..984	CDD:293787
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910