DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fs(2)Ket and kpnb1

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	XP_002940197.1	Gene:	kpnb1 / 100216264	XenbaseID:	XB-GENE-994068	Length:	876	Species:	Xenopus tropicalis

Alignment Length:	876	Identity:	543/876 - (61%)
Similarity:	679/876 - (77%)	Gaps:	3/876 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MQLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHL 71
            |:|:.|||||||||:|||.:|:.||||||..|||.|:..||::|.|.|||.|||:|||||:||.|
Frog     1 MELVTILEKTVSPDRNELEAAQKFLEQAAVENLPTFVVELSKVLANPANSQVARVAAGLQIKNSL 65

  Fly    72 TSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPINRWPMLI 136
            ||||..|..|||.||....:..|..||..:|..||||:.|||.|:||||.:|..|:|:|:||.||
Frog    66 TSKDPDVKAQYQQRWLAIDAHARGEIKTYVLRTLGTESYRPSSASQCVAGIACAEIPVNQWPQLI 130

  Fly   137 QTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAAT 201
            ..||..|....|:|..:||.|||||||||||....::::||::|||||.||||.||||:||||||
Frog   131 PQLVANVTDPNSTEHMKESTLEAIGYICQDIDPEQLQHKSNEILTAIIQGMRKEEPSNNVRLAAT 195

  Fly   202 TALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQAL 266
            .||.|||||||.||:|:.||::||:||||||||.|:::.|||||.|||||:|||||||.||..||
Frog   196 NALLNSLEFTKENFDKESERHYIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPAL 260

  Fly   267 FPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPV 331
            |.||:.|||::.|.||||||||||||||||:|||||:.||.:|||.|:..||.||:||||:|.|:
Frog   261 FAITVEAMKNEIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPI 325

  Fly   332 LVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTF 396
            |.:.||||||.||:|.|:|.|||.||||:|||||||:|||||||||||:|::|:||:||||||.|
Frog   326 LTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAF 390

  Fly   397 GSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLEC 461
            |.:|.|.|:..|||||.|||||||.||.|.||:||||.|||.||||:::||||||:.||..||:|
Frog   391 GCILEGPESCQLKPLVIQAMPTLIELMKDPSVVVRDTTAWTVGRICELLPEAAINDVYLAPLLQC 455

  Fly   462 FVKSLKSEPRVAANVCWAFIGLSDAAWEAA-VTNDGETPETYALSPYFEYIITQLLETTDRSDGA 525
            .::.|.:|||||:||||||..|::||:||| ||:|.|.|.:|.||..||.|:.:|||||||.||.
Frog   456 LIEGLGAEPRVASNVCWAFSSLAEAAYEAADVTDDQEEPSSYCLSSSFEVIVQKLLETTDRPDGH 520

  Fly   526 QANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLC 590
            |.|||.|||:|||:::|||..|||..||:|||||:|||.||:|||:.|.:.|||.||||||||||
Frog   521 QNNLRSAAYEALMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLC 585

  Fly   591 ATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPA 655
            ||||:|||||..|||.||||.:|.:||.||.|:|| ||.|||:|.:|||||||:|||:|.|||.|
Frog   586 ATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAG-SGGVQEDALMAVSTLVEVLGAEFLKYMEA 649

  Fly   656 FKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVL 720
            ||.||.:||||:.|||||.|||||.||:.|||:..::|:.:|:|.:|:.||....:||:||||:|
Frog   650 FKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNILPFCDEMMQLLLENLGNENVHRSVKPQIL 714

  Fly   721 SAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGLKGV 785
            |.|||:||:||..|..||.:||:.|:.||..|.|.:::||.:|:|||||..|||||||||||||.
Frog   715 SVFGDVALAIGGEFKKYLDVVLNTLQQASQAQVDKSDYDMVDYLNELREGCLEAYTGIIQGLKGD 779

  Fly   786 DQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPRLYPLLD-DAIIT 849
            .:..|.|||.::|.:..|:|||..||.:.|.:||::|..||.||||||:||..:..|:: ..:|.
Frog   780 QENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDSVVACGAGLIGDLCTAFGKDVLKLVEARPLIH 844

  Fly   850 QFLAEGKRSKAQRTKMLCTWAVKEIKKINTQ 880
            :.|.||:|||..:||.|.|||.||::|:..|
Frog   845 ELLTEGRRSKTNKTKTLATWATKELRKLKNQ 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	534/860 (62%)
		IBN_N	27..107	CDD:281761	44/79 (56%)
		HEAT repeat	136..162	CDD:293787	12/25 (48%)
		HEAT repeat	179..209	CDD:293787	23/29 (79%)
		HEAT repeat	223..255	CDD:293787	22/31 (71%)
		HEAT repeat	264..291	CDD:293787	18/26 (69%)
		HEAT repeat	330..360	CDD:293787	19/29 (66%)
		HEAT repeat	373..401	CDD:293787	19/27 (70%)
		HEAT_EZ	386..441	CDD:290247	38/54 (70%)
		HEAT repeat	414..444	CDD:293787	23/29 (79%)
		HEAT repeat	457..482	CDD:293787	15/24 (63%)
		HEAT repeat	508..540	CDD:293787	22/31 (71%)
kpnb1	XP_002940197.1	KAP95	2..871	CDD:227540	540/869 (62%)
		HEAT repeat	128..160	CDD:293787	17/31 (55%)
		HEAT repeat	172..204	CDD:293787	24/31 (77%)
		HEAT repeat	215..244	CDD:293787	19/28 (68%)
		HEAT repeat	323..354	CDD:293787	19/30 (63%)
		HEAT repeat	367..395	CDD:293787	19/27 (70%)
		HEAT repeat	408..438	CDD:293787	23/29 (79%)
		HEAT repeat	451..476	CDD:293787	15/24 (63%)
		HEAT repeat	503..535	CDD:293787	22/31 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	506	1.000	Domainoid score	I335
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1707
Inparanoid	1	1.050	1071	1.000	Inparanoid score	I249
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222415at33208
OrthoFinder	1	1.000	-	-		FOG0003173
OrthoInspector	1	1.000	-	-		oto103480
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R600
SonicParanoid	1	1.000	-	-		X2136
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190