DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fs(2)Ket and LOC100005536

DIOPT Version :9

Sequence 1:	NP_001246108.1	Gene:	Fs(2)Ket / 35336	FlyBaseID:	FBgn0262743	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	XP_021333077.1	Gene:	LOC100005536 / 100005536	-ID:	-	Length:	889	Species:	Danio rerio

Alignment Length:	844	Identity:	177/844 - (20%)
Similarity:	312/844 - (36%)	Gaps:	208/844 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVN-TANSAVARMAAGLQLKNHL 71
            |::.:|:.:.|||.....:.:..|||  .:..|:|...|..:|.: .:.....|..:||.|||:
Zfish    12 QVLQLLKDSQSPDTATQRAVQEKLEQ--LNQFPDFNNYLIFVLTSLKSEDEPTRSLSGLILKNN- 73

  Fly    72 TSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIEL----PINRW 132
                  |...||:    ||..:.:.||...|..:|.    ||...:....:.:..:    .:..|
Zfish    74 ------VKAHYQN----FPPAVADFIKRECLNNIGD----PSPLIRATIGILITTIASKGELQTW 124

  Fly   133 PMLIQTLVNKVVSEGSSEMHRESALEAIGYICQD----IRFGVMENQSNDVLTAIIHGMRKVEPS 193
            |.|:..|.|.:.||..:..  |.:..|:..||:|    :....:....|.::...:...:...|.
Zfish   125 PELLPQLCNLLNSEDYNTC--EGSFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPK 187

  Fly   194 NHVRLAATTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYM 258
              :|..|...: |.....::....|....||..:...||. :|.::.....:.||.::.:....:
Zfish   188 --IRSHAIACV-NQFIIGRAQALMDNIDTFIESLFALATD-EDCEVRKNVCRALVMLLEVRIDRL 248

  Fly   259 EPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARG 323
            .|:| .::....|...:..::.|||:..|||..:                   |.|.:.|....|
Zfish   249 IPHM-HSIIQYMLQRTQDADENVALEACEFWLTL-------------------AEQPICKEALSG 293

  Fly   324 ALQFLTPVLVEKL---------------------------------------------------T 337
            .|..|.|:||..:                                                   .
Zfish   294 HLVQLIPILVNGMKYSEIDIILLKGDVEEDDTIPDSEQDIKPRFHKSRTVTLQHEGGEGEEGEDI 358

  Fly   338 KQDECDDEDT---WSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSV 399
            .:||.||:||   |:..|.::..|.|||....||::||:||.:|..:..|:|..:::.::..|::
Zfish   359 DEDEDDDDDTLSDWNLRKCSAAALDVLANVFRDELLPHLLPLLKGLLFHPDWVIKESGILVLGAI 423

  Fly   400 LNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDII----PEAAINETYLQTLL- 459
            ..|. ...:.|.:.:.:|.||:.:.|...:||....||..|....:    |:|     :|:.|:
Zfish   424 AEGC-MQGMVPYLPELIPHLIQCLCDKKALVRSIACWTLSRYAHWVVSQPPDA-----HLKPLMT 482

  Fly   460 ECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLLETTDRSDG 524
            |...:.|....||....|.||..|.    |.|.|.         |.||..||:..|:....:...
Zfish   483 ELLKRILDGNKRVQEAACSAFATLE----EEACTE---------LVPYLSYILDTLVFAFGKYQH 534

  Fly   525 AQANLRCAAYQALMDMI---KNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQ 586
            ....:...|...|.|.:   .|.|    ..:|:....::::.|::        ...|:..|..|:
Zfish   535 KNLLILYDAIGTLADSVGHHLNQP----EYIQKLMPPLIQKWNEL--------KDEDKDLFPLLE 587

  Fly   587 SL--------------------LCATL------QSVL--RKVHEQDAPQISDAIMTALLTMFNSS 623
            .|                    .|.||      |:::  ::..:.:||. .|.::.||..:...:
Zfish   588 CLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYSQQPDQYEAPD-KDFMIVALDLLSGLA 651

  Fly   624 AGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALK 688
            .|..|.|.:  .:|.|.::.||.......||                :|..::..|.||:.:|..
Zfish   652 EGLGGHVDQ--LVARSNIMTLLFQCMQDTMP----------------EVRQSSFALLGDLTKACF 698

  Fly   689 DLMVPYSNEIMTVLINNLTEPTIHRTVKPQVLS-------AFGDIALSIGNHFLPYLSMVLDML 745
            ..:.|...|.|.:|..||         .|:.:|       |.|:|.:.:|....||:::||..|
Zfish   699 PHVKPCIAEFMPILGTNL---------NPEFISVCNNATWAIGEICMQMGVEMQPYVALVLPHL 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fs(2)Ket	NP_001246108.1	KAP95	17..876	CDD:227540	175/835 (21%)
		IBN_N	27..107	CDD:281761	21/80 (26%)
		HEAT repeat	136..162	CDD:293787	6/25 (24%)
		HEAT repeat	179..209	CDD:293787	4/29 (14%)
		HEAT repeat	223..255	CDD:293787	7/31 (23%)
		HEAT repeat	264..291	CDD:293787	7/26 (27%)
		HEAT repeat	330..360	CDD:293787	12/83 (14%)
		HEAT repeat	373..401	CDD:293787	6/27 (22%)
		HEAT_EZ	386..441	CDD:290247	12/54 (22%)
		HEAT repeat	414..444	CDD:293787	9/29 (31%)
		HEAT repeat	457..482	CDD:293787	8/25 (32%)
		HEAT repeat	508..540	CDD:293787	5/31 (16%)
LOC100005536	XP_021333077.1	KAP95	22..758	CDD:227540	175/834 (21%)
		HEAT repeat	93..114	CDD:293787	4/24 (17%)
		HEAT repeat	127..155	CDD:293787	8/29 (28%)
		HEAT repeat	165..202	CDD:293787	5/39 (13%)
		HEAT repeat	213..239	CDD:293787	6/26 (23%)
		HEAT repeat	252..281	CDD:293787	8/29 (28%)
		HEAT repeat	438..466	CDD:293787	9/27 (33%)
		HEAT repeat	479..509	CDD:293787	9/33 (27%)
		HEAT repeat	520..546	CDD:293787	4/25 (16%)
		HEAT repeat	561..592	CDD:293787	6/38 (16%)
		HEAT repeat	661..695	CDD:293787	10/49 (20%)
		HEAT repeat	707..737	CDD:293787	10/38 (26%)
		HEAT repeat	748..776	CDD:293787	3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910