Protein Alignment TM9SF2 and TM9SF4

DIOPT Version :9

• Sequence 1: NP_001260637.1
• Gene: TM9SF2 / 35335
• FlyBaseID: FBgn0032880
• Length: 659
• Species: Drosophila melanogaster
• Sequence 2: NP_055557.2
• Gene: TM9SF4 / 9777
• HGNCID: 30797
• Length: 642
• Species: Homo sapiens
• Alignment Length: 657
• Identity: 288/657 - (43%)
• Similarity: 418/657 - (63%)
• Gaps: 36/657 - (5%)

  Fly    13 VVLLHLATPTQAFYLPGLAPVNFCKKTDVSSTCKSEILLYVNRLNTEESVIPYEYHHFDFCLGEE 77
            ::|..|...|.|||:||:||:||.:...|.        :...:|.:..:.:||||:...||...:
Human    12 LLLFSLMCETSAFYVPGVAPINFHQNDPVE--------IKAVKLTSSRTQLPYEYYSLPFCQPSK 68

  Fly    78 QNSPVENLGQVVFGERIRPGPYKIQFLENQQCATTCVKTYKGDDPASNRRMMVLKKGISLNYQHH 142
            .....||||:|:.|:||...|:::.....::|...|.::.|.......:..:|.:: |:.:|..|
Human    69 ITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAER-ITEDYYVH 132

  Fly   143 WIVDNMPVTWCYPL------ENGKQYCGIGFPMGC-LVRSDGEGCPINSIYNQPMHYYPFNHVDL 200
            .|.||:||.....|      ::.|:...:.|..|. |..:|     :|.||   :|    ||:..
Human   133 LIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTD-----VNKIY---LH----NHLSF 185

  Fly   201 EITYHSGQSEDWGIQFGNSGRIISVKVTPKSIKHTD---KENPNCLSTEPLAISENSLKAGEQLE 262
            .:.||   .||......::.|::..:|.|:||:..|   .|..:|...|....|...:...::.:
Human   186 ILYYH---REDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQ 247

  Fly   263 IVYTYSVKFVKNDSIKWSSRWDYILESMPHTNIQWFSILNSLVIVLFLSGMVAMIMLRTLHKDIA 327
            :.:||||.:.::| |||:||||..| :|....|.||||:||:|:|.||||:::||::|||.||||
Human   248 LYFTYSVHWEESD-IKWASRWDTYL-TMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIA 310

  Fly   328 RYNQMDSGEDAQEEFGWKLVHGDVFRPPRKGMLLSVFLGSGVQVLVMAMITLAFACLGFLSPANR 392
            .||:.|..||..||.|||||||||||||:..|:||..||||:|:..|.:|.:..|.||.|||::|
Human   311 NYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSR 375

  Fly   393 GALMTCSMVLFVSLGTPAGYVSARIYKSFGGLKWKSNVILTSIVCPGVVFSLFFVMNLVLWGENS 457
            |||||.:..||:.:|...|:.:.|:|::..|.:||.....|:.:.|||||.:.||:|..:||::|
Human   376 GALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHS 440

  Fly   458 SGAVPFSTLIALLALWFGVSVPLTFVGAYFGFRKRALEHPVRTNQIPRQIPDQSIYTQPIPGIVM 522
            ||||||.|::|||.:|||:|:||.::|.||||||:..::||||||||||||:|..|.....||:|
Human   441 SGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILM 505

  Fly   523 GGVLPFGCIFIQLFFILSSLWSSQIYYMFGFLFLVFVILVITCSETTILLCYFHLCAEDYHWWWR 587
            .|:||||.:||:||||.|::|.:|.||:||||||||:|||::||:.:|::.||.||||||.||||
Human   506 AGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWR 570

  Fly   588 SFLTSGFTAVYLFIYCCHYFVTKLSIKDSASTFLYFGYTAIMVFLFFLLTGTIGFFACFWFIRKI 652
            :||.||.:|.|:.:|...|||.||.|.:...:.|||||||:||..|:||||||||:|.:.|:|||
Human   571 NFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPSLLYFGYTALMVLSFWLLTGTIGFYAAYMFVRKI 635

  Fly   653 YSVVKVD 659
            |:.||:|
Human   636 YAAVKID 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF2	NP_001260637.1	EMP70	64..613	CDD:397233	246/558 (44%)
TM9SF4	NP_055557.2	EMP70	55..599	CDD:397233	247/561 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1278
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53553
OrthoDB	1	1.010	-	-		D135708at33208
OrthoFinder	1	1.000	-	-		FOG0000597
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100462
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1983
SonicParanoid	1	1.000	-	-		X358
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760