Protein Alignment TM9SF2 and TM9SF2

DIOPT Version :9

• Sequence 1: NP_001260637.1
• Gene: TM9SF2 / 35335
• FlyBaseID: FBgn0032880
• Length: 659
• Species: Drosophila melanogaster
• Sequence 2: NP_004791.1
• Gene: TM9SF2 / 9375
• HGNCID: 11865
• Length: 663
• Species: Homo sapiens
• Alignment Length: 674
• Identity: 446/674 - (66%)
• Similarity: 534/674 - (79%)
• Gaps: 29/674 - (4%)

  Fly     4 LSGLLPLLG------VVLLHL----ATP----TQAFYLPGLAPVNFCKKTDVSSTCKSEILLYVN 54
            :|..||:|.      ::||.|    |.|    :.|||||||||||||.:...|..||:||.|:||
Human     1 MSARLPVLSPPRWPRLLLLSLLLLGAVPGPRRSGAFYLPGLAPVNFCDEEKKSDECKAEIELFVN 65

  Fly    55 RLNTEESVIPYEYHHFDFCLGEEQNSPVENLGQVVFGERIRPGPYKIQFLENQQCATTCVKTYKG 119
            ||::.|||:||||..||||...|...|.||||||:|||||.|.|||..|.:.:.|...|.|||..
Human    66 RLDSVESVLPYEYTAFDFCQASEGKRPSENLGQVLFGERIEPSPYKFTFNKKETCKLVCTKTYHT 130

  Fly   120 DDPASNRRMMVLKKGISLNYQHHWIVDNMPVTWCYPLENGKQYCGIGFPMGCLVRSDG---EGCP 181
            :.....:::..|||.:.||||||||||||||||||.:|:|:::|..|||:||.:...|   :.|.
Human   131 EKAEDKQKLEFLKKSMLLNYQHHWIVDNMPVTWCYDVEDGQRFCNPGFPIGCYITDKGHAKDACV 195

  Fly   182 INSIYNQPMHYYPFNHVDLEITYHSGQSEDWGIQFGNSG-RIISVKVTPKSIKHTDKENPNCLST 245
            |:|.:::...:|.|||||::|.||.       ::.|:.| |:::.|:.|||.|||..:.|:| |.
Human   196 ISSDFHERDTFYIFNHVDIKIYYHV-------VETGSMGARLVAAKLEPKSFKHTHIDKPDC-SG 252

  Fly   246 EPLAISENSLKAGEQLEIVYTYSVKFVKNDSIKWSSRWDYILESMPHTNIQWFSILNSLVIVLFL 310
            .|:.||.   ||..:::|.|||||.|.::|.|:|:|||||||||||||:||||||:|||||||||
Human   253 PPMDISN---KASGEIKIAYTYSVSFEEDDKIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFL 314

  Fly   311 SGMVAMIMLRTLHKDIARYNQMDSGEDAQEEFGWKLVHGDVFRPPRKGMLLSVFLGSGVQVLVMA 375
            ||||||||||||||||||||||||.|||||||||||||||:|||||||||||||||||.|:|:|.
Human   315 SGMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPRKGMLLSVFLGSGTQILIMT 379

  Fly   376 MITLAFACLGFLSPANRGALMTCSMVLFVSLGTPAGYVSARIYKSFGGLKWKSNVILTSIVCPGV 440
            .:||.||||||||||||||||||::||:|.||||||||:||.||||||.|||:||:|||.:|||:
Human   380 FVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGI 444

  Fly   441 VFSLFFVMNLVLWGENSSGAVPFSTLIALLALWFGVSVPLTFVGAYFGFRKRALEHPVRTNQIPR 505
            ||:.||:|||:||||.||.|:||.||:|:|||||.:||||||:||||||:|.|:|||||||||||
Human   445 VFADFFIMNLILWGEGSSAAIPFGTLVAILALWFCISVPLTFIGAYFGFKKNAIEHPVRTNQIPR 509

  Fly   506 QIPDQSIYTQPIPGIVMGGVLPFGCIFIQLFFILSSLWSSQIYYMFGFLFLVFVILVITCSETTI 570
            |||:||.||:|:|||:|||:||||||||||||||:|:||.|:|||||||||||:||||||||.||
Human   510 QIPEQSFYTKPLPGIIMGGILPFGCIFIQLFFILNSIWSHQMYYMFGFLFLVFIILVITCSEATI 574

  Fly   571 LLCYFHLCAEDYHWWWRSFLTSGFTAVYLFIYCCHYFVTKLSIKDSASTFLYFGYTAIMVFLFFL 635
            ||||||||||||||.|||||||||||||..||..|||.:||.|..:|||.||||||.|||.:|||
Human   575 LLCYFHLCAEDYHWQWRSFLTSGFTAVYFLIYAVHYFFSKLQITGTASTILYFGYTMIMVLIFFL 639

  Fly   636 LTGTIGFFACFWFIRKIYSVVKVD 659
            .||||||||||||:.|||||||||
Human   640 FTGTIGFFACFWFVTKIYSVVKVD 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF2	NP_001260637.1	EMP70	64..613	CDD:397233	374/552 (68%)
TM9SF2	NP_004791.1	EMP70	75..619	CDD:367285	369/547 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159943
Domainoid	1	1.000	800	1.000	Domainoid score	I74
eggNOG	1	0.900	-	-		E1_KOG1278
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	925	1.000	Inparanoid score	I352
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53553
OrthoDB	1	1.010	-	-		D135708at33208
OrthoFinder	1	1.000	-	-		FOG0000597
OrthoInspector	1	1.000	-	-		oto91395
orthoMCL	1	0.900	-	-		OOG6_100462
Panther	1	1.100	-	-	LDO	PTHR10766
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1983
SonicParanoid	1	1.000	-	-		X358
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800