Protein Alignment TM9SF2 and EMP70

DIOPT Version :9

• Sequence 1: NP_001260637.1
• Gene: TM9SF2 / 35335
• FlyBaseID: FBgn0032880
• Length: 659
• Species: Drosophila melanogaster
• Sequence 2: NP_013184.1
• Gene: EMP70 / 850772
• SGDID: S000004073
• Length: 667
• Species: Saccharomyces cerevisiae
• Alignment Length: 695
• Identity: 254/695 - (36%)
• Similarity: 378/695 - (54%)
• Gaps: 86/695 - (12%)

  Fly    13 VVLLHLATPTQAFYLPGLAPVNFCKKTDVSSTCKSEILLYVNRL------------------NTE 59
            ::|....:..:||||||:||..: ::.|       .|.|.||.|                  :.|
Yeast    11 LLLYFFVSTVKAFYLPGVAPTTY-REND-------NIPLLVNHLTPSMNYQHKDEDGNNVSGDKE 67

  Fly    60 ESVIPYEYHH--FDFCLGEEQNSPVENLGQVVFGERIRPGPYKIQFLENQQCATTCVKTYKGDDP 122
            ..:..|:|::  |.||..|:.....|:||.|:||:||...|:::..|:.::|.:.|.....|||.
Yeast    68 NFLYSYDYYYNRFHFCQPEKVEKQPESLGSVIFGDRIYNSPFQLNMLQEKECESLCKTVIPGDDA 132

  Fly   123 ASNRRMMVLKKGISLNYQHHWIVDNMPVT-WCYPLENGKQYCGIGFPMGCLVRSDG---EGCP-- 181
            ....::  :|.|...|    |::|.:|.. ..|.......:.|.||.:|.:..:.|   |..|
Yeast   133 KFINKL--IKNGFFQN----WLIDGLPAAREVYDGRTKTSFYGAGFNLGFVQVTQGTDIEATPKG 191

  Fly   182 ---------------INSIYNQPMHYYPFNHVDLEITYHS-GQSEDWGIQFGNSGRIISVKVTPK 230
                           .|.:....:.|:. ||.|:.|.||. |:        ||. |::.|.|.|.
Yeast   192 AETTDKDVELETRNDRNMVKTYELPYFA-NHFDIMIEYHDRGE--------GNY-RVVGVIVEPV 246

  Fly   231 SIKHTDKENPNCLST--EPLAISENSLKAGEQLEIVYTYSVKFVKNDS-IKWSSRWDYILESMPH 292
            |||   :.:|....|  .||.:.|     |...|:.:||||||  |:| ..|::|||..|. :..
Yeast   247 SIK---RSSPGTCETTGSPLMLDE-----GNDNEVYFTYSVKF--NESATSWATRWDKYLH-VYD 300

  Fly   293 TNIQWFSILNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSGEDAQEEFGWKLVHGDVFRPPRK 357
            .:|||||::|..::|:.||.:|...:||.|..|.||||:::..:|.||:.||||.||||||.|.:
Yeast   301 PSIQWFSLINFSLVVVLLSSVVIHSLLRALKSDFARYNELNLDDDFQEDSGWKLNHGDVFRSPSQ 365

  Fly   358 GMLLSVFLGSGVQVLVMAMITLAFACLGFLSPANRGALMTCSMVLFVSLGTPAGYVSARIYKSFG 422
            .:.||:.:|||||:.:|...::.||.||||||::||:|.|...:|:...|....|.|..|||.|.
Yeast   366 SLTLSILVGSGVQLFLMVTCSIFFAALGFLSPSSRGSLATVMFILYALFGFVGSYTSMGIYKFFN 430

  Fly   423 GLKWKSNVILTSIVCPGVVFSLFFVMNLVLWGENSSGAVPFSTLIALLALWFGVSVPLTFVGAYF 487
            |..||:|:|||.::.||.:..:...:|..|...:|||.:|.|||..::.|||..|:||:|.|:..
Yeast   431 GPYWKANLILTPLLVPGAILLIIIALNFFLMFVHSSGVIPASTLFFMVFLWFLFSIPLSFAGSLI 495

  Fly   488 GFRKRAL--EHPVRTNQIPRQIPDQSIYTQPIPGIVMGGVLPFGCIFIQLFFILSSLWSSQIYYM 550
            . |||..  |||.:||||.||||.|..|.:.||..::.|:.|||.|.::|:||.:|||.::|:||
Yeast   496 A-RKRCHWDEHPTKTNQIARQIPFQPWYLKTIPATLIAGIFPFGSIAVELYFIYTSLWFNKIFYM 559

  Fly   551 FGFLFLVFVILVITCSETTILLCYFHLCAEDYHWWWRSFLTSGF-TAVYLFIYCCHYFVTKLSIK 614
            |||||..|::|.:|.|..|||:.|..||.|::.|.||.|:..|. .|:|:||:...:  ||..:.
Yeast   560 FGFLFFSFLLLTLTSSLVTILITYHSLCLENWKWQWRGFIIGGAGCALYVFIHSILF--TKFKLG 622

  Fly   615 DSASTFLYFGYTAIMVFLFFLLTGTIGFFACFWFIRKIYSVVKVD 659
            ...:..||.||::::..|..|:||:|||.:...|:|||||.:|||
Yeast   623 GFTTIVLYVGYSSVISLLCCLVTGSIGFISSMLFVRKIYSSIKVD 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF2	NP_001260637.1	EMP70	64..613	CDD:397233	218/578 (38%)
EMP70	NP_013184.1	EMP70	72..624	CDD:397233	218/581 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	380	1.000	Domainoid score	I105
eggNOG	1	0.900	-	-		E1_KOG1278
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	429	1.000	Inparanoid score	I278
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53553
OrthoFinder	1	1.000	-	-		FOG0000597
OrthoInspector	1	1.000	-	-		mtm9200
orthoMCL	1	0.900	-	-		OOG6_100462
Panther	1	1.100	-	-	LDO	PTHR10766
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1983
SonicParanoid	1	1.000	-	-		X358
TreeFam	1	0.960	-	-
	12	11.860