DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TM9SF2 and EMP1

DIOPT Version :9

Sequence 1:	NP_001260637.1	Gene:	TM9SF2 / 35335	FlyBaseID:	FBgn0032880	Length:	659	Species:	Drosophila melanogaster
Sequence 2:	NP_196645.2	Gene:	EMP1 / 830951	AraportID:	AT5G10840	Length:	648	Species:	Arabidopsis thaliana

Alignment Length:	672	Identity:	310/672 - (46%)
Similarity:	432/672 - (64%)	Gaps:	63/672 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LPLLGVVLLHLATPTQAFYLPGLAPVNFCKKTDVSSTCKSEILLYVNRLNTEESVIPYEYHHFDF 72
            :.|:.::.:|.|   .:|||||:||.:| :|.|       |:.:.||:|.:.::.:||.|:...|
plant    20 IALIFLLFIHGA---HSFYLPGVAPQDF-EKGD-------ELKVKVNKLTSIKTQLPYSYYSLPF 73

  Fly    73 CLGEEQNSPVENLGQVVFGERIRPGPYKIQFLENQQC-----ATTCVKTYKGDDPASNRRMMVLK 132
            |...:.....||||:|:.|:||...||..:..|.|.|     .|...||.|           ..|
plant    74 CRPSKIVDSTENLGEVLRGDRIENAPYSFKMREAQMCNILGRVTLDAKTAK-----------AFK 127

  Fly   133 KGISLNYQHHWIVDNMPVTWCYPLENGKQ-----YCGIGFPMGCLVRSDGEGCPINSIYNQPMHY 192
            :.|...|:.:.|:||:|:.  .|:|...|     ...:|:.:|  ::...||       ::...:
plant   128 EKIDDEYRVNMILDNLPLV--VPIERVDQGSPSVVYQLGYHVG--LKGQYEG-------SKEQKF 181

  Fly   193 YPFNHVDLEITYHSGQSEDWGIQFGNSGRIISVKVTPKSIKHTDK----ENPNCLSTEP----LA 249
            :..||:...:.||.....|       :.||:..:|.|.|:||..:    |.....:.:|    |.
plant   182 FMHNHLAFTVRYHRDIQTD-------AARIVGFEVKPYSVKHEYEGEWSEKTRLTTCDPHTKRLV 239

  Fly   250 ISENSLKAGEQ-LEIVYTYSVKFVKNDSIKWSSRWD-YILESMPHTNIQWFSILNSLVIVLFLSG 312
            :|..:.:..|| .||::||.|.|.::: :||:|||| |:|  |....|.||||:|||:|||||||
plant   240 VSSATPQEVEQKKEIIFTYDVDFQESE-VKWASRWDTYLL--MSDNQIHWFSIVNSLMIVLFLSG 301

  Fly   313 MVAMIMLRTLHKDIARYNQMDSGEDAQEEFGWKLVHGDVFRPPRKGMLLSVFLGSGVQVLVMAMI 377
            ||||||||||::||:|||::::.|:||||.|||||||||||.|....||.|::|:|||.|.|..:
plant   302 MVAMIMLRTLYRDISRYNELETQEEAQEETGWKLVHGDVFRLPTNSDLLCVYVGTGVQCLGMVFV 366

  Fly   378 TLAFACLGFLSPANRGALMTCSMVLFVSLGTPAGYVSARIYKSFGGLKWKSNVILTSIVCPGVVF 442
            |:.||.||||||:|||.|||..::|:|.:|..|||.|:|:||.|.|.:||.....|:.:.|.||.
plant   367 TMIFAMLGFLSPSNRGGLMTAMLLLWVFMGLFAGYASSRLYKMFKGTEWKRIAFRTAFLFPAVVS 431

  Fly   443 SLFFVMNLVLWGENSSGAVPFSTLIALLALWFGVSVPLTFVGAYFGFRKRALEHPVRTNQIPRQI 507
            ::|||:|.::||:.|||||||.|:.||:.||||:||||.|||.|.||:|.|.:.||:||:|||||
plant   432 AIFFVLNALIWGQKSSGAVPFGTMFALIFLWFGISVPLVFVGGYIGFKKPAADDPVKTNKIPRQI 496

  Fly   508 PDQSIYTQPIPGIVMGGVLPFGCIFIQLFFILSSLWSSQIYYMFGFLFLVFVILVITCSETTILL 572
            |:|:.|..|:..|::||:||||.:||:|||||:|:|.:|.||:|||||||||||::||:|.|::|
plant   497 PEQAWYMNPVFSILIGGILPFGAVFIELFFILTSIWLNQFYYIFGFLFLVFVILIVTCAEITVVL 561

  Fly   573 CYFHLCAEDYHWWWRSFLTSGFTAVYLFIYCCHYFVTKLSIKDSASTFLYFGYTAIMVFLFFLLT 637
            |||.||:|||.|||||:||||.:|:|||:|...||.|||.|....|..|||||..|..:.||:||
plant   562 CYFQLCSEDYLWWWRSYLTSGSSALYLFLYATFYFFTKLQITKLVSAMLYFGYMLIASYAFFVLT 626

  Fly   638 GTIGFFACFWFIRKIYSVVKVD 659
            |||||:||.||.|.|||.||:|
plant   627 GTIGFYACLWFTRLIYSSVKID 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF2	NP_001260637.1	EMP70	64..613	CDD:397233	265/568 (47%)
EMP1	NP_196645.2	EMP70	65..605	CDD:367285	266/571 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	69	1.000	Domainoid score	I3428
eggNOG	1	0.900	-	-		E1_KOG1278
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H128721
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53553
OrthoDB	1	1.010	-	-		D641127at2759
OrthoFinder	1	1.000	-	-		FOG0000597
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100462
Panther	1	1.100	-	-	O	PTHR10766
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X358
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.830