DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TM9SF2 and TM9SF3

DIOPT Version :9

Sequence 1:	NP_001260637.1	Gene:	TM9SF2 / 35335	FlyBaseID:	FBgn0032880	Length:	659	Species:	Drosophila melanogaster
Sequence 2:	NP_647979.1	Gene:	TM9SF3 / 38635	FlyBaseID:	FBgn0035622	Length:	592	Species:	Drosophila melanogaster

Alignment Length:	639	Identity:	195/639 - (30%)
Similarity:	319/639 - (49%)	Gaps:	112/639 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KSEILLYVNRL----NTEESVIPYEYHHFDFCLGEEQNSPV----ENLGQVVFGERIRPGPYKIQ 102
            :.|::|::|.:    |.:|:   |.|....||.|  |.|.:    |.|.:.:.|..:....|:::
  Fly    41 REEVVLWMNTVGPYHNRQET---YAYFSLPFCSG--QKSSISHYHETLSEALQGVELEFSGYEME 100

  Fly   103 FLENQQCATTCVKTYKGDDPASNRRMMVLKK--------GISLNYQHHWIVDNMPVTWCYPLENG 159
            |              |.|.|.|...|:.|::        .:...|.:...:|.:|: |      |
  Fly   101 F--------------KSDAPKSVICMVTLQEESAKAFTYAVKNEYWYQMYIDGLPI-W------G 144

  Fly   160 KQYCGIGFPMGCLVRSDGEGCPINSIYNQPMHYYPFNHVDLEITYHSGQSEDWGIQFGNSGRIIS 224
            |        :|.....||:             ||.|.|...:|.|             |..:|:.
  Fly   145 K--------VGERDERDGK-------------YYIFTHKKFDIGY-------------NGQQIVD 175

  Fly   225 VKVTPKSIKHTDKENPNCLSTEPLAISENSLKAGEQLEIVYTYSVKFVKNDSIKWSSRWD-YILE 288
            :.:|                ||    ....||.|..:.  ::|.|.: |...:::.:|:| |:..
  Fly   176 ITLT----------------TE----GREELKPGSHIN--FSYEVNW-KPSKVEFKNRFDKYLDP 217

  Fly   289 SMPHTNIQWFSILNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSGEDAQ----EEFGWKLVHG 349
            :.....|.||||.||.::|:||.|:|:||::|||.||.|||::.:..:|.:    :|:|||.|||
  Fly   218 NFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKDEEIDDMERDLGDEYGWKQVHG 282

  Fly   350 DVFRPPRKGMLLSVFLGSGVQVLVMAMITLAFACLGFLSPANRGALMTCSMVLFVSLGTPAGYVS 414
            ||||.|...:|.|..:|:|.|::.:....:.||.:|.|. ..||::::.::.::.:.....||..
  Fly   283 DVFRSPPNTLLFSALVGAGYQLISVVFCVIMFAIVGELY-TERGSMLSTAIFVYAATSPINGYFG 346

  Fly   415 ARIYKSFGGLKWKSNVILTSIVCPGVVFSLFFVMNLVLWGENSSGAVPFSTLIALLALWFGVSVP 479
            ..:|...||..|...:::::...|..|....|::|.:..|.::|.|:||.|::|:..:...|.:|
  Fly   347 GSLYARLGGRMWIRQMLVSAFTVPVAVCGTAFLINFIAIGYHASRAIPFGTMVAVTCICLFVILP 411

  Fly   480 LTFVGAYFGFRKRAL----EHPVRTNQIPRQIPDQSIYTQPIPGIVMGGVLPFGCIFIQLFFILS 540
            ||.||...|   |.|    :.|.|.|.:||.||::..|.:|:..:::|||||||.|||:::||.:
  Fly   412 LTLVGTVVG---RNLDGQPDFPCRVNAVPRPIPEKKWYMEPLIIVLLGGVLPFGSIFIEMYFIFT 473

  Fly   541 SLWSSQIYYMFGFLFLVFVILVITCSETTILLCYFHLCAEDYHWWWRSFLTSGFTAVYLFIYCCH 605
            |.|:.:|||::||:.|||.||.:.....||:..||.|.||||.|.|.||:.:|.|::|::.|..:
  Fly   474 SFWAYKIYYVYGFMLLVFSILTVVTVCVTIVCTYFLLNAEDYRWQWTSFMAAGSTSIYVYAYSFY 538

  Fly   606 YFVTKLSIKDSASTFLYFGYTAIMVFLFFLLTGTIGFFACFWFIRKIYSVVKVD 659
            ||..|..:.....|..||||.|:......::.||:|:.....|:|||||.||:|
  Fly   539 YFFFKTKMFGLFQTAFYFGYMALFSGALGIICGTVGYVGTNLFVRKIYSNVKID 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF2	NP_001260637.1	EMP70	64..613	CDD:397233	172/569 (30%)
TM9SF3	NP_647979.1	EMP70	60..530	CDD:281048	167/556 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461659
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1278
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D135708at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10766
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850