DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TM9SF2 and Tm9sf4

DIOPT Version :9

Sequence 1:	NP_001260637.1	Gene:	TM9SF2 / 35335	FlyBaseID:	FBgn0032880	Length:	659	Species:	Drosophila melanogaster
Sequence 2:	XP_006235346.1	Gene:	Tm9sf4 / 296279	RGDID:	1307768	Length:	644	Species:	Rattus norvegicus

Alignment Length:	658	Identity:	284/658 - (43%)
Similarity:	415/658 - (63%)	Gaps:	37/658 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VVLLHLATPTQAFYLPGLAPVNFCKKTDVSSTCKSEILLYVNRLNTEESVIPYEYHHFDFCLGEE 77
            ::||.|......||:||:||:||.:...|.        :...:|.:..:.:||||:...||...:
  Rat    13 LLLLCLTCKGSTFYVPGVAPINFHQNDPVE--------IKAVKLTSSRTQLPYEYYSLPFCQPNK 69

  Fly    78 QNSPVENLGQVVFGERIRPGPYKIQFLENQQCATTCVKTYKGDDPASNRRMMVLKKGISLNYQHH 142
            .....||||:|:.|:||...|:::.....::|...|.::.|.......:..:|.:: |:..|..|
  Rat    70 ITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCGQSNKPVILTVEQSRLVAER-ITEEYYVH 133

  Fly   143 WIVDNMPVTWCYPL-------ENGKQYCGIGFPMGC-LVRSDGEGCPINSIYNQPMHYYPFNHVD 199
            .|.||:||.....|       ::.|:...:.|..|. |..:|     :|.||   :|    ||:.
  Rat   134 LIADNLPVATRLELYSSNRDSDDKKKEKDVQFEHGYRLGFTD-----VNKIY---LH----NHLS 186

  Fly   200 LEITYHSGQSEDWGIQFGNSGRIISVKVTPKSIKHTD---KENPNCLSTEPLAISENSLKAGEQL 261
            ..:.||...:|:   ...::.|::..:|.|:||:..|   .|..:|...|........:...::.
  Rat   187 FILYYHREDTEE---DQEHTYRVVRFEVIPQSIRLEDLKIDEKSSCTLPEGANSLPQEIDPTKEN 248

  Fly   262 EIVYTYSVKFVKNDSIKWSSRWDYILESMPHTNIQWFSILNSLVIVLFLSGMVAMIMLRTLHKDI 326
            ::.:||||.:.::| |||:||||..| :|....|.||||:||:|:|.||||:::||::|||.|||
  Rat   249 QLYFTYSVHWEESD-IKWASRWDTYL-TMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDI 311

  Fly   327 ARYNQMDSGEDAQEEFGWKLVHGDVFRPPRKGMLLSVFLGSGVQVLVMAMITLAFACLGFLSPAN 391
            |.||:.|..||..||.|||||||||||||:..|:||..||||:|:..|.:|.:..|.||.|||::
  Rat   312 ANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSS 376

  Fly   392 RGALMTCSMVLFVSLGTPAGYVSARIYKSFGGLKWKSNVILTSIVCPGVVFSLFFVMNLVLWGEN 456
            ||||||.:..||:.:|...|:.:.|:|::..|.:||.....|:.:.|||||.:.||:|..:||::
  Rat   377 RGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKH 441

  Fly   457 SSGAVPFSTLIALLALWFGVSVPLTFVGAYFGFRKRALEHPVRTNQIPRQIPDQSIYTQPIPGIV 521
            |||||||.|::|||.:|||:|:||.::|.||||||:..::||||||||||||:|..|.....||:
  Rat   442 SSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGIL 506

  Fly   522 MGGVLPFGCIFIQLFFILSSLWSSQIYYMFGFLFLVFVILVITCSETTILLCYFHLCAEDYHWWW 586
            |.|:||||.:||:||||.|::|.:|.||:||||||||:|||::||:.:|::.||.||||||.|||
  Rat   507 MAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWW 571

  Fly   587 RSFLTSGFTAVYLFIYCCHYFVTKLSIKDSASTFLYFGYTAIMVFLFFLLTGTIGFFACFWFIRK 651
            |:||.||.:|.|:.:|...|||.||.|.:...:.||||||.:||..|:||||||||:|.:.|:||
  Rat   572 RNFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPSLLYFGYTTLMVLSFWLLTGTIGFYAAYMFVRK 636

  Fly   652 IYSVVKVD 659
            ||:.||:|
  Rat   637 IYAAVKID 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF2	NP_001260637.1	EMP70	64..613	CDD:397233	244/559 (44%)
Tm9sf4	XP_006235346.1	EMP70	56..601	CDD:281048	245/562 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1278
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53553
OrthoDB	1	1.010	-	-		D135708at33208
OrthoFinder	1	1.000	-	-		FOG0000597
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100462
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X358
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730