Protein Alignment TM9SF2 and TM9SF1

DIOPT Version :10

• Sequence 1: NP_610053.1
• Gene: TM9SF2 / 35335
• FlyBaseID: FBgn0032880
• Length: 659
• Species: Drosophila melanogaster
• Sequence 2: NP_006396.2
• Gene: TM9SF1 / 10548
• HGNCID: 11864
• Length: 606
• Species: Homo sapiens
• Alignment Length: 670
• Identity: 206/670 - (30%)
• Similarity: 333/670 - (49%)
• Gaps: 99/670 - (14%)

  Fly    11 LGVVLLHLATPTQAFYLPGLAPVNFCKKTDVSSTCKSEILLYVNRL----NTEESVIPYEYHHFD 71
            |.:::|.|.|.    :.||:..|...|..|       .::||||::    |.:|:   |.|:...
Human    15 LPILILLLGTG----HGPGVEGVTHYKAGD-------PVILYVNKVGPYHNPQET---YHYYQLP 65

  Fly    72 FCLGEEQNSPVENLGQVVFGERIRPGPYKIQFLENQQCATTCVKTYKGDDPASNRRMMVLKKGIS 136
            .|..|:......:||:|:.|:|:....|:|:|.||.:....|      ....|:.::..|::.|.
Human    66 VCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILC------HMQLSSAQVEQLRQAIE 124

  Fly   137 LNYQHHWIVDNMPVTWCYPLENGKQYCGIGFPMGCLVRSDGEGCPINSIYNQPMHYYPFNHVDLE 201
            ..|...::||::|:         :.:.|.....|.|..|...|.              :.|:|..
Human   125 ELYYFEFVVDDLPI---------RGFVGYMEESGFLPHSHKIGL--------------WTHLDFH 166

  Fly   202 ITYHSGQSEDWGIQFGNSGRIISVKVTPKSIKHTDKENPNCLSTEPLAISENSLKAGEQLEIVYT 266
            :.:|             ..|||...|:.:.:|      |:.|         :.|:..|.|.:.:|
Human   167 LEFH-------------GDRIIFANVSVRDVK------PHSL---------DGLRPDEFLGLTHT 203

  Fly   267 YSVKFVKNDSIKWSSR--------WDYILESMPHTNIQWFSILNSLVIVLFLSGMVAMIMLRTLH 323
            |||::.:....:.|.|        :...||      |.|.||:||:|:|..|.|.||:|::|.|.
Human   204 YSVRWSETSVERRSDRRRGDDGGFFPRTLE------IHWLSIINSMVLVFLLVGFVAVILMRVLR 262

  Fly   324 KDIARYN------QMDSGED-AQEEFGWKLVHGDVFR-PPRKGMLLSVFLGSGVQVLVMAMITLA 380
            .|:||||      ...||:| .|.:.|||::|.|||| ||.:|:|.:| ||.|.|.|.:....:.
Human   263 NDLARYNLDEETTSAGSGDDFDQGDNGWKIIHTDVFRFPPYRGLLCAV-LGVGAQFLALGTGIIV 326

  Fly   381 FACLGFLSPANRGALMTCSMVLFVSLGTPAGYVSARIYKSFGGLKWKSNVILTSIVCPGVVFSLF 445
            .|.||..:....||:.:.:::|:......:||||:..|:..||.:|..|:|||:.:.....|..:
Human   327 MALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTW 391

  Fly   446 FVMNLVLWGENSSGAVPFSTLIALLALWFGVSVPLTFVGAYFGFRKRA-LEHPVRTNQIPRQIPD 509
            .|:|.|.|...|:.|:|.:|::.||.:|..|..|||.:|..||....: .:.|.||..|.|:||.
Human   392 SVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPP 456

  Fly   510 QSIYTQPIPGIVMGGVLPFGCIFIQLFFILSSLWSSQIYYMFGFLFLVFVILVITCSETTILLCY 574
            |..|...:..:.:||.|||..|.::|::|.:::|..:.|.::|.||.||.||:...:..:|.|.|
Human   457 QPWYKSTVIHMTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTY 521

  Fly   575 FHLCAEDYHWWWRSFLTSGFTAVYLFIYCCHYFVTKLSIKDSASTFLYFGYTAIMVFLFFLLTGT 639
            |.|..|||.|||||.|:.|.|.:::|:|...|:..:.::..:..|..:|||:.:..::|||:.||
Human   522 FQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGT 586

  Fly   640 IGFFACFWFIRKIYSVVKVD 659
            |.||:...|||.||..:|:|
Human   587 ISFFSSLKFIRYIYVNLKMD 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF2	NP_610053.1	EMP70	64..613	CDD:460774	172/565 (30%)
TM9SF1	NP_006396.2	EMP70	58..562	CDD:460774	172/570 (30%)