Protein Alignment CarT and SV2A

DIOPT Version :10

• Sequence 1: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_055664.3
• Gene: SV2A / 9900
• HGNCID: 20566
• Length: 742
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 62/302 - (20%)
• Similarity: 110/302 - (36%)
• Gaps: 92/302 - (30%)

  Fly   363 IGCLMWSKDLMDTRQFSAAGEL------LSIRLARSELDVNKRKMTIVASTVSLTLFVIFGFAAF 421
            |.|.:.|:|:..:.:.:..|.:      .|.::..:|:    ::|.:|.....|.....|..:||
Human    54 IQCSVSSEDIEKSFKTNPCGSISFTTSKFSYKIDFAEM----KQMNLVTGKQRLIKRAPFSISAF 114

  Fly   422 GFWRCRVEHNAHISNDAWRNFLQSQDVPGLEFFEMNAIQTATNNFSLSNKLGPGGFGSVYKGKLQ 486
            .: .|  |:.|......|.|.  :.|||    :::.::|..|:.:   |::     .|:: ||..
Human   115 SY-IC--ENEAIPMPTHWENV--NPDVP----YQLVSLQNQTHEY---NEV-----ASLF-GKTM 161

  Fly   487 DGREIAVKRLSSSSGQGKQEF----------------MNEIVLISKLQHRNLVRVLGCCVEGTEK 535
            |...|  ||:.........||                :||.:|..           |...|..|.
Human   162 DRNRI--KRIQRIQNLDLWEFFCRKKAQLKKKRGVPQINEQMLFH-----------GTSSEFVEA 213

  Fly   536 LLIYGF-LKNKSLDTFVFDARKKLELD--WPKRF---EIIEG----------------------- 571
            :.|:.| .:...:...||........|  :..||   :|..|
Human   214 ICIHNFDWRINGVHGAVFGKGTYFARDAAYSSRFCKDDIKHGNTFQIHGVSLQQRHLFRTYKSMF 278

  Fly   572 IARGLL--YLHRDSR-LRVIHRDLKVSNI---LLDEKMNPKI 607
            :||.|:  |::.||: :|...:|....|:   .:|:..||||
Human   279 LARVLIGDYINGDSKYMRPPSKDGSYVNLYDSCVDDTWNPKI 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	MFS_SLC22	152..551	CDD:340875	41/210 (20%)
		xylE	<306..>342	CDD:182225
SV2A	NP_055664.3	synapt_SV2	1..742	CDD:130366	62/302 (21%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..144		21/102 (21%)