DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and SLC22A14

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	XP_006713479.2	Gene:	SLC22A14 / 9389	HGNCID:	8495	Length:	675	Species:	Homo sapiens

Alignment Length:	584	Identity:	142/584 - (24%)
Similarity:	264/584 - (45%)	Gaps:	76/584 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LSELRQRHKPESQPSVDEAFDLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFC-AFNQLFMADT 78
            |..||..|..:     |:.|  .:||..:||||.:|:.||....:|:.:...|. |.:.:|.|..
Human   119 LRRLRAVHTKQ-----DDKF--ANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQK 176

  Fly    79 PDDYWCRIPELL----DLPLEQRKSLSIPKELDNDELVYSKCYTY-GVNWT--QLLESGEEDDLT 136
            |   :|....:|    .|...::.:|:||:..:...|.   |:.| .|.|.  .:::.|..|..|
Human   177 P---YCNTSWILAVGPHLSKAEQLNLTIPQAPNGSFLT---CFMYLPVPWNLDSIIQFGLNDTDT 235

  Fly   137 TMEPNASWPLIKCPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLND 201
                        |..||.| ......|::.:|||||..:............|.|:|..:|.|:.|
Human   236 ------------CQDGWIY-PDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITD 287

  Fly   202 RGGRRLSYFVCLATLLAGSLMTSLSKD-----FWTWAGSRVIVGLTIPAVYQIPFIISLE---LV 258
            :.||..:..:.|..|:.....|:....     |:.:..|:.:||..|.:       |||.   ||
Human   288 KMGRYPAILLSLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISS-------ISLATEWLV 345

  Fly   259 GENYRSFVTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRG 323
            || :|:...::...|:..|.:||:|:.|....|..|..:..:....:..|::::|||||||:|:|
Human   346 GE-HRAHAIILGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKG 409

  Fly   324 RLEEALKILERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILI 388
            :::||.::|...|.||.:..|..:         .|:|:..:||:....:.|.|:...:...|:::
Human   410 KVKEAKQVLCYAASVNKKTIPSNL---------LDELQLPRKKVTRASVLDFCKNRQLCKVTLVM 465

  Fly   389 TLSWFANETVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGV 453
            :..||.....|..||.....||.:.:....:.:::|:|:.|||.:.:...||:|.|:::::...:
Human   466 SCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAII 530

  Fly   454 ACVITVMLPD---------------DAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIG 503
            .|::.:.||:               :....|:::.::.:..|:|:..:.:.:..||.||.:|..|
Human   531 WCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATG 595

  Fly   504 IGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEEGEE 567
            :|..|.....|  .|..:|.:.:....||:.:...|:::.......||||....|.:::....:
Human   596 LGLVSLASVAG--AILSLTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQ 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	134/547 (24%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	92/391 (24%)
SLC22A14	XP_006713479.2	2A0119	141..650	CDD:273328	134/546 (25%)
SLC22A14	XP_006713479.2	MFS	270..641	CDD:119392	92/389 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010