DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CarT and Slc22a7

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_445989.2	Gene:	Slc22a7 / 89776	RGDID:	621699	Length:	535	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	174/559 - (31%)
Similarity:	260/559 - (46%)	Gaps:	47/559 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DDLLPTIGEFGKYQKLLVFGICLP-ACIPCGFCAFNQLFMADTPDDYWCRIP------ELLDLPL 94
            :|||..:|.||.:|...:..:.|| ..:|..|..  .:|||..|..: |.:|      ...||.|
  Rat     4 EDLLDKVGGFGPFQLRNLVLMALPRMLLPMHFLL--PVFMAAVPAHH-CALPGAPANLSHQDLWL 65

  Fly    95 EQRKSLSIPKELDNDELVYSKC-----------YTYGVNWTQLLESGEEDDLTTMEPNASWPLIK 148
            |..    :|:|.|..   :|.|           .|.|   |::..|||.:.    ||..    :.
  Rat    66 EAH----LPRETDGS---FSSCLRFAYPQTVPNVTLG---TEVSNSGEPEG----EPLT----VP 112

  Fly   149 CPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCL 213
            |.|||||:.|...|:|..::||||.|.....|.......|..||..::|.|:||.|||....|..
  Rat   113 CSQGWEYDRSEFSSTIATEWDLVCQQRGLNKITSTCFFIGVLVGAVVYGYLSDRFGRRRLLLVAY 177

  Fly   214 ATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGI 278
            .:.|...||::.|.::..:..:|.:.|..:.....|...:.||.:...:|:...|::..|::.|:
  Rat   178 VSSLVLGLMSAASINYIMFVVTRTLTGSALAGFTIIVLPLELEWLDVEHRTVAGVISTVFWSGGV 242

  Fly   279 MLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREF 343
            :||:.|.||.|.|..|....:||.....:.::.:|||.||||.:||:|||.|.|...||:|||..
  Rat   243 LLLALVGYLIRSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLLSCAKLNGRPV 307

  Fly   344 PEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPA 408
            .|. .|..||   .:.:...::.:......||.||..:|..::...:.||.....|.||:.....
  Rat   308 GEG-SLSQEA---LNNVVTMERALQRPSYLDLFRTSQLRHISLCCMMVWFGVNFSYYGLTLDVSG 368

  Fly   409 LGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPD-DAVDETLVL 472
            ||.|.|.:..|...|||||.:..::.:...|||. ....|:||......|.:|.. :.......|
  Rat   369 LGLNVYQTQLLFGAVELPSKIMVYFLVRRLGRRL-TEAGMLLGAALTFGTSLLVSLETKSWITAL 432

  Fly   473 YLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMG 537
            .:|.||...|:|...|.|..|||||.:|..|:|.::.:|.||....|....|....|.||.|..|
  Rat   433 VVVGKAFSEAAFTTAYLFTSELYPTVLRQTGLGLTALMGRLGASLAPLAALLDGVWLLLPKVAYG 497

  Fly   538 FLSMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQFKD 576
            .::::...|.|.||||...:||:||::.|.  |:.|.:|
  Rat   498 GIALVAACTALLLPETKKAQLPETIQDVER--KSTQEED 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	165/535 (31%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	113/369 (31%)
Slc22a7	NP_445989.2	2A0119	11..521	CDD:273328	165/535 (31%)
Slc22a7	NP_445989.2	MFS	144..511	CDD:119392	114/371 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920