DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CarT and SLC22A16

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_149116.2	Gene:	SLC22A16 / 85413	HGNCID:	20302	Length:	577	Species:	Homo sapiens

Alignment Length:	560	Identity:	158/560 - (28%)
Similarity:	255/560 - (45%)	Gaps:	72/560 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPLEQRKSLSIPKELD 107
            :|.||::|::|.| ||....|.||......:||..|| .:.||.|..:...:....|
Human    13 VGHFGRFQRVLYF-ICAFQNISCGIHYLASVFMGVTP-HHVCRPPGNVSQVVFHNHS-------- 67

  Fly   108 NDELVYSKCYTYGVNWT-----QLLESGEEDDLTTMEPNAS-WPLIKCPQ---------GWEYNT 157
                          ||:     .||.||::|.:|....|.. |.|.:|.:         |:||..
Human    68 --------------NWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTG 118

  Fly   158 SV--------------VW-SSIVIDFDLVCDQD-----IYPTIGLAALNTGGPVGVYLFGLLNDR 202
            |.              .| |:.|..::||||:.     |.|......|     :|...||..:||
Human   119 SKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVL-----LGSVTFGYFSDR 178

  Fly   203 GGRRLSYFVCLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVT 267
            .|||:..:...:::....:..:.:.|::|:..:|..:.:.......:.|:..:|.:|...|::.:
Human   179 LGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWAS 243

  Fly   268 VMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKIL 332
            |...:|:..|.:|::...||.|.|.....|.|.....:.|..:|:||:|.|||..||.|||.||:
Human   244 VHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIV 308

  Fly   333 ERMAKVN---GREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFA 394
            :.|||.|   ..:..|.:.|.|:..:.....:.||.     .|:.|....::..:|:.:.|.||.
Human   309 DIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKH-----NLSYLFYNWSITKRTLTVWLIWFT 368

  Fly   395 NETVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITV 459
            ....:...|.....||.|:|::.||..|||:|:|......||..|||..|:.|:....:||.:.:
Human   369 GSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVM 433

  Fly   460 MLPDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYL 524
            ::|.......:|..:|.|..:.|:|.:||.:..|||||.||.:.:|:.|.:..|..|..||...|
Human   434 VIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDL 498

  Fly   525 GKDNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEE 564
            ....:.:|.:.:|.:::|.|:..|:|||||..||..|.||
Human   499 SSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEE 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	155/554 (28%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	104/371 (28%)
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	155/554 (28%)
SLC22A16	NP_149116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..577
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920