DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and OCT4

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_188702.2	Gene:	OCT4 / 821613	AraportID:	AT3G20660	Length:	526	Species:	Arabidopsis thaliana

Alignment Length:	601	Identity:	163/601 - (27%)
Similarity:	273/601 - (45%)	Gaps:	113/601 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDIEDNDGDEYDELSELRQRHKPESQPSVDEAFDLDDLLPT-IGEFGKYQ-KLLVFGICLPACI 63
            |...||.:|:  |....|.::...:.:...:|...:|::|.. .||||::| |..|.     .||
plant     1 MESPEDRNGN--DVRQPLLEKIPVKKEAEGEERLCIDEMLQRYCGEFGRWQLKHFVL-----TCI 58

  Fly    64 PCGFCAFNQLFM--ADTPDDYWCRIPELLDLPLEQRKSLSIPKELDNDELVYSKCYTYGVNWTQL 126
            .....||:.:.|  ||...::.|                           |.|.|....:|
plant    59 AWALEAFHTMVMIFADQEPEWRC---------------------------VGSDCRVGSLN---- 92

  Fly   127 LESGEEDDLTTMEPNASWPLIKC---PQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGL--AALN 186
                                  |   |..||: |:...||.|.::.|:|. |.| .:||  |...
plant    93 ----------------------CELDPSSWEW-TAGKGSSTVSEWGLICG-DKY-KVGLVQALFF 132

  Fly   187 TGGPVGVYLFGLLND-RGGRRLSY-FVCLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQI 249
            .|..:|..:||.|:| :.||:.|. .||:...:.| :.|:.|.::||:...|.:.|.:...|...
plant   133 AGCMIGAGVFGHLSDSKLGRKGSLTVVCIINAIFG-IATAFSPNYWTYVVLRFLTGFSTGGVGLT 196

  Fly   250 PFIISLELVGENYRSFVTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMP- 313
            .|:::.|.:|.:.|....:.|..|:::||.:|||:.|:.|.|..|..::|||...:.|  .|:|
plant   197 AFVLATEPIGPSKRGVAGMSTFYFFSAGIAVLSGIAYVFRSWRELFIVSSLPSLLFLL--IVIPF 259

  Fly   314 --ESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLC 376
              |||||.|:||:::||:|::..:||.|||..|..|.|.|:..:..:  ..::.......|.|:.
plant   260 ISESPRWYLVRGKVDEAMKLMHSIAKTNGRHIPAGVTLALDDDVENN--NGERNTAVEGSLKDVI 322

  Fly   377 RTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRR 441
            .:|.||::.::.....|....||.|||.....|.||.|::.|::||.|:|::......:|.:||:
plant   323 LSPLMRMRLVISVAISFTVSIVYYGLSLNVGNLKTNLYLNVFVNAVSEMPAFAITAVLLDKYGRK 387

  Fly   442 WPLSL-SMILGGVACVITVML----PDDAVDETLVLYLVSKAL----LSASFLIIYPFAGELYPT 497
             |||: :.....|.|::...:    |..:|      .:||..|    ::.::.:::.:..||:||
plant   388 -PLSIGTQWFSCVFCLVGFSVWGAGPWKSV------RMVSGVLGIFGMAGTYNLLFIYIAELFPT 445

  Fly   498 QVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTI 562
            .||...:|.::....:|.|..||:..||::   ||..:.....::||.....|||||:..|..|:
plant   446 VVRNAALGCATQAAQMGAILAPFVVVLGEE---LPFGVFAVCGLVGGGLAFYLPETLNKPLYDTM 507

  Fly   563 ------------EEGE 566
                        |.||
plant   508 FGMHEAESESNRERGE 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	150/538 (28%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	112/384 (29%)
OCT4	NP_188702.2	MFS_OCT_plant	90..496	CDD:340936	126/449 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1021
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm1022
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060