DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CarT and slc22a15.2

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001039179.1	Gene:	slc22a15.2 / 734018	XenbaseID:	XB-GENE-5824718	Length:	487	Species:	Xenopus tropicalis

Alignment Length:	549	Identity:	154/549 - (28%)
Similarity:	252/549 - (45%)	Gaps:	101/549 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCR---------IPELL 90
            |||:....|||||..||.|.           .|....|:::|       |:         :||.|
Frog     2 DLDEAFLYIGEFGCCQKRLT-----------AFLTLLQVYVA-------CQSMLIVLVGAVPEYL 48

  Fly    91 DLPLEQRKSLSIPKELDNDELVYSKCYTYGVNWTQLLESGEEDDLTTMEPNASWPLIKCPQGWEY 155
                           :||:::..||     ..:|:.|.  :.::.|::.  :.|.||| .:.::.
Frog    49 ---------------IDNEDISASK-----EEYTKHLH--DTNNFTSIV--SEWHLIK-NEAYKV 88

  Fly   156 N--TSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLA 218
            |  :|:.::.::|                         |..|||.|:|:.|||..|...|...:.
Frog    89 NLASSLFFAGLLI-------------------------GNILFGPLSDKLGRRPVYLSGLFFDIT 128

  Fly   219 GSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSG 283
            ....|:|:..:..:|.||..||:....:..:.|:::.|.||::|.:....:|...:..||...:.
Frog   129 FGYCTALAPSYEVFAVSRFFVGIMNGGMALVSFVLTQEYVGKSYWALTGSLTNLIFAVGIAFYAL 193

  Fly   284 VTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVH 348
            :.:..|:|..|:::.:.|...:||..|::|||||||...|...||..:|:.||..||.|.|..
Frog   194 LGFYIRNWRTLAFVANSPGIFFFLLSFLLPESPRWLYSHGYTTEAEGVLQSMAVGNGVERPVV-- 256

  Fly   349 LKLEAQIRRDKLKK---QKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALG 410
                      |||.   ...|.|: .:.||.:...:|.:|||:...|:....||.||:.....|.
Frog   257 ----------KLKSCPGTSSKSAH-SVFDLVKYGVLRWRTILLMYIWYVCSLVYYGLTLNAGELK 310

  Fly   411 TNQYVSFFLSAVVELPSYLCCWYFMD-TW-GRRWPLSLSMILGGVACVITVMLPD---DAVDETL 470
            .|.|::..|..:||:|::..|.||:: :| |||...:..:...|.||:.|:.||:   |.::.|
Frog   311 GNLYLNVALYGLVEVPAFPLCLYFIEKSWSGRRKATAGFLGFAGFACIFTIFLPETNGDLLNPT- 374

  Fly   471 VLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVI 535
            ||.|..|..:||:|.::|.:..|||||.||..|:|..:.....|.|..|||..:...|..:|.|.
Frog   375 VLALFGKLSVSAAFNVVYIYTSELYPTVVRNAGLGVCAMACRFGGILSPFIPTMKSLNPSMPFVA 439

  Fly   536 MGFLSMLGGMTGLRLPETLHHRLPQTIEE 564
            .|...:..|:..|.||||.:..:.::||:
Frog   440 FGISGISAGILSLLLPETRNKPIAESIED 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	148/535 (28%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	116/376 (31%)
slc22a15.2	NP_001039179.1	MFS	48..455	CDD:391944	131/470 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920