DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CarT and Slc22a23

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001028339.1	Gene:	Slc22a23 / 73102	MGIID:	1920352	Length:	689	Species:	Mus musculus

Alignment Length:	669	Identity:	156/669 - (23%)
Similarity:	256/669 - (38%)	Gaps:	127/669 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DLD-DLLPTIGEF-GKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCR----IPELLDLP 93
            |.| .:||.:|.. |.|||.||....:||.. .||..|:..|:.|.| |:|||    ..||....
Mouse    79 DYDGSVLPFLGGLGGGYQKTLVVLTWIPALF-IGFSQFSDSFLLDQP-DFWCRGAGKGTELAGAT 141

  Fly    94 LEQRKSLSIPKELDNDELVYSKCYTYG--VNWTQLLESGEEDDLTTMEPNASW------------ 144
            :..|                     :|  .|||        ....|....|||
Mouse   142 VTGR---------------------WGDMGNWT--------SPSATPFSTASWGTTSNRSNSSDT 177

  Fly   145 PLIKCPQG------------WEY--NTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYL 195
            |.:..|.|            |:|  .|.:: .::|..:|||||......|...:|..|...|..:
Mouse   178 PPLPSPPGKGNNDSNCDCHAWDYGIRTGLI-QNVVSKWDLVCDNTWKVHIAKFSLLVGLIFGYLI 241

  Fly   196 FGLLNDRGGRRLSYFVCLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGE 260
            .|.:.|..|||.........:|...|..:||.:...::..|...|..:..:....:.:.:||...
Mouse   242 TGCIADWVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPP 306

  Fly   261 NYRSFVTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRL 325
            ..|..:|::......:|..|:.|:..|.|||..|..:...||....||..:.|||.|||:...:.
Mouse   307 GKRFIITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQF 371

  Fly   326 EEALKILERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITL 390
            |.|.|::..:.:.|... ||:....:..::.::..::.||    |.:..:..|.|:....:::.:
Mouse   372 ESAKKLILYLTQKNCVS-PESDIKGVMPELEKELSRRPKK----VCIVKVVGTRNLWKNIVVLCV 431

  Fly   391 SWFANETVY-------LGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSM 448
            :......::       :|.....|.| .|.|..::..|.:.|.|.|.....:...|||..|.|.|
Mouse   432 NSLTGYGIHHCFARSMMGHEVKVPLL-ENFYADYYTMASIALASCLAMCLVVKFLGRRGGLLLFM 495

  Fly   449 ILGGVACVITVML----------PDDAVDETLVLYLVS--KALLSASFLIIYPFA---------- 491
            ||..:|.::.:.|          ||..:...|.:.:..  |...|.:|.|:..||
Mouse   496 ILTALASLLQLGLLNLIGKYSQHPDSELQLKLAVGMSDSVKDKFSIAFSIVGMFASHAVGSLSVF 560

  Fly   492 --GELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGLRLPETL 554
              .|:.||.:|..|:|......|.|::..|.|....:....|..:|....:::..:..|.|||:.
Mouse   561 FCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESR 625

  Fly   555 HHRLPQTIEEGEEFGKNWQFKDCCRCAQKPEILSQPASYENLDVLAGSSTNASEVELELRDSRRV 619
            :..||:.|..||.:.:......  :..::|.:|                |||     ||:|...:
Mouse   626 NQNLPENIANGEHYTRQPLLPH--KKGEQPLLL----------------TNA-----ELKDYSGL 667

  Fly   620 REPAPRIDERTPLDTTASG 638
            .:.| .:.:..|...||:|
Mouse   668 HDVA-AVGDGLPEGATANG 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	136/580 (23%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	88/399 (22%)
Slc22a23	NP_001028339.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		2A0119	98..631	CDD:273328	130/570 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..188		6/25 (24%)
		MFS	230..>359	CDD:119392	30/128 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100