Protein Alignment CarT and SLC22A5

DIOPT Version :10

• Sequence 1: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_001295051.1
• Gene: SLC22A5 / 6584
• HGNCID: 10969
• Length: 581
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 176/560 - (31%)
• Similarity: 282/560 - (50%)
• Gaps: 45/560 - (8%)

  Fly    35 DLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPLEQRKS 99
            |.|::...:||:|.:|:|:.| :...:.||.||...:.:|:..|| ::.||:|:..:|....|..
Human     3 DYDEVTAFLGEWGPFQRLIFF-LLSASIIPNGFTGLSSVFLIATP-EHRCRVPDAANLSSAWRNH 65

  Fly   100 LSIPKELDNDELVYSKCYTYGV----NWTQL-LESGEEDDLTTMEPNASWPLIKCPQGWEYNTSV 159
             ::|..|.:...|...|..|.:    |::.| ||.|.:.||..:|..:      |..|||::..|
Human    66 -TVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQES------CLDGWEFSQDV 123

  Fly   160 VWSSIVIDFD------------------------LVCDQDIYPTIGLAALNTGGPVGVYLFGLLN 200
            ..|:||.:.|                        |||:.|....:.::....|..:|.::.|.|:
Human   124 YLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLS 188

  Fly   201 DRGGRRLSYFVCLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYR-S 264
            ||.||:...||.:......|.:...||:|..:....|:||:...:.|...|::..|::|::.| .
Human   189 DRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRII 253

  Fly   265 FVTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEAL 329
            |.|:..|.||..|.|:|....|..|||..|....::|........:.:|||||||:.:||.|||.
Human   254 FSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAE 318

  Fly   330 KILERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFA 394
            .|:.:.||.||...|..:....|.|    .|..:|::..|:  .||.||.|:|:.||:..:.|..
Human   319 VIIRKAAKANGIVVPSTIFDPSELQ----DLSSKKQQSHNI--LDLLRTWNIRMVTIMSIMLWMT 377

  Fly   395 NETVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITV 459
            ....|.|||...|.|..:.:|:.||||:||:|:|:..|..:....||:.::.::.|||...:...
Human   378 ISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQ 442

  Fly   460 MLPDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYL 524
            ::|.|......||.:|.|..::|:|.::|.:..|||||.||.:|:|.||....||.|..|:..||
Human   443 LVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL 507

  Fly   525 GKDNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEE 564
            |..:..||.::||.|::|..:..|.|||:....||.||::
Human   508 GAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQ 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	MFS_SLC22	152..551	CDD:340875	135/423 (32%)
		xylE	<306..>342	CDD:182225	17/35 (49%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	172/546 (32%)