Protein Alignment CarT and SLC22A4

DIOPT Version :10

• Sequence 1: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 172/562 - (30%)
• Similarity: 294/562 - (52%)
• Gaps: 26/562 - (4%)

  Fly    35 DLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPLEQRKS 99
            |.|:::..:||:|.:|:|:.| :...:.||.||...:.:|:|.|| ::.||:|:..:|....|.:
Human     3 DYDEVIAFLGEWGPFQRLIFF-LLSASIIPNGFNGMSVVFLAGTP-EHRCRVPDAANLSSAWRNN 65

  Fly   100 LSIPKELDNDELVYSKCYTYGV----NWTQL-LESGEEDDLTTMEPNASWPLIKCPQGWEYNTSV 159
             |:|..|.:...|...|..|.:    |::.| ||.|.:.||..:|..:      |..|||::..|
Human    66 -SVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQES------CLDGWEFSQDV 123

  Fly   160 VWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLAGSLMTS 224
            ..|::|.:::|||:.:....:..:....|..:|.::.|.|:||.||:...|..:|.....|.:..
Human   124 YLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQI 188

  Fly   225 LSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYR-SFVTVMTCTFYTSGIMLLSGVTYLE 288
            .|..:..:....||||:...:.|.:.||:..|::|::.| .|.|:..|||:..|.|||....|..
Human   189 FSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFI 253

  Fly   289 RDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEA 353
            |||..|....::|........:.:|||||||:.:.|..||..|:::.||:|....|..:...:|
Human   254 RDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVE- 317

  Fly   354 QIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQYVSFF 418
              ..:.||:||     ..:.||.||.|:.:.||:..|.|......|..||...|.|..:.|::.|
Human   318 --ELNPLKQQK-----AFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCF 375

  Fly   419 LSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALLSAS 483
            |||::|:|:|:..|..:.|..||:.::..:..||...:...::|.|....::.|.::.|..::::
Human   376 LSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSA 440

  Fly   484 FLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGL 548
            |.::|.|..|||||.||.:.:|.:|....:|.|..|:..|||..|..||.::||.|::|.|:..|
Human   441 FSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTL 505

  Fly   549 RLPETLHHRLPQTIEEGEE---FGKNWQFKDCCRCAQKPEIL 587
            ..||:|...||:|:|:.::   |....:.:|.....:.|::|
Human   506 FFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMETEENPKVL 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	MFS_SLC22	152..551	CDD:340875	125/399 (31%)
		xylE	<306..>342	CDD:182225	14/35 (40%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	164/522 (31%)