Protein Alignment CarT and SLC22A2

DIOPT Version :9

• Sequence 1: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Alignment Length: 584
• Identity: 187/584 - (32%)
• Similarity: 294/584 - (50%)
• Gaps: 57/584 - (9%)

  Fly    36 LDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAF--NQLFMADTPDDYWCRIPELLDLPLE--- 95
            :||:|...|||..:||.:.|   |.|.:...|...  ..:|:..|| |:.||.|.:.:|.|.
Human     5 VDDVLEHGGEFHFFQKQMFF---LLALLSATFAPIYVGIVFLGFTP-DHRCRSPGVAELSLRCGW 65

  Fly    96 ---QRKSLSIPKELDNDELVYSKCYTYGVNWTQLLESGEE--DDLTTMEPNAS-WPLIKCPQGWE 154
               :..:.::|......|....:|..|.|:|.|   |..:  |.|.:::.|.| .||..|..||.
Human    66 SPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQ---STFDCVDPLASLDTNRSRLPLGPCRDGWV 127

  Fly   155 YNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLL-- 217
            |.|.  .||||.:|:|||.......:..:::|.|..:|....|.:.||.||:|    ||.|.:
Human   128 YETP--GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKL----CLLTTVLI 186

  Fly   218 ---AGSLMTSLSKDFWTW-AGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGI 278
               ||.|| ::|..: || ...|:|.||...|.:.|.:|:..|.||..||..|.:.....||.|:
Human   187 NAAAGVLM-AISPTY-TWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGL 249

  Fly   279 MLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREF 343
            ::|:||.|....|..|.:..|||.:.:.||.:.:|||||||:.:.:..||::|::.:||.||:..
Human   250 LVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSL 314

  Fly   344 PEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPA 408
            |        |.::|.:|:::..|..|....||.|||.:|..|:::..:||.:..:|.||..:...
Human   315 P--------ASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGL 371

  Fly   409 LGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLY 473
            .|.|.|:.||.||:||.|:.......:|..|||:|.:.|.::.|.||:.:|.:|.|.....:::.
Human   372 AGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIIS 436

  Fly   474 LVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITY-LGKDNLKLPLVIMG 537
            .:.:..::.::.|:.....|||||.:|.:|:...|.:..:|.|..||:.| |....|:|||::.|
Human   437 CLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFG 501

  Fly   538 FLSMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQFKDCCRCAQKPEILSQPASY---ENLDV 598
            .|.::.|...|.||||....||:||||.|..             |:|....:...|   :.||:
Human   502 VLGLVAGGLVLLLPETKGKALPETIEEAENM-------------QRPRKNKEKMIYLQVQKLDI 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	174/534 (33%)
		MFS	182..551	CDD:119392	123/375 (33%)
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	174/534 (33%)
		MFS	124..492	CDD:119392	127/383 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.920