Protein Alignment CarT and SLC22A3

DIOPT Version :10

• Sequence 1: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 186/592 - (31%)
• Similarity: 287/592 - (48%)
• Gaps: 60/592 - (10%)

  Fly    28 PSVDEAFDLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDL 92
            ||.|||      |..:||||::|:.:...:||.. :...|.....:|:...||.||||.|..  .
Human     2 PSFDEA------LQRVGEFGRFQRRVFLLLCLTG-VTFAFLFVGVVFLGTQPDHYWCRGPSA--A 57

  Fly    93 PLEQRKSLSIPKELDNDELVYS----------KCYTYGVNWTQLLESGEEDDLTTME-------- 139
            .|.:|...| |:|..|.....|          :|..|      |||:..:....|..
Human    58 ALAERCGWS-PEEEWNRTAPASRGPEPPERRGRCQRY------LLEAANDSASATSALSCADPLA 115

  Fly   140 --PNASWPLIKCPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDR 202
              ||.|.||:.|..||.|  :...|:||.:|||||.......:..|.||.|...|.:..|...||
Human   116 AFPNRSAPLVPCRGGWRY--AQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADR 178

  Fly   203 GGRRLSYFV-CLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFV 266
            .||.:.|.: ||...:.| ::.:.:.:|..:...|.:.|:.....:...::|..|:||...|..|
Human   179 YGRIVIYLLSCLGVGVTG-VVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIV 242

  Fly   267 TVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKI 331
            .::...|:|.||::|.|:.|...:|..:....:||.:.:.||.:|:|||||||:.|.:.::||:|
Human   243 GIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQI 307

  Fly   332 LERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANE 396
            |.|:||.||:....          ...::....::::|....||.|||.||..|:::..:||.:.
Human   308 LRRIAKCNGKYLSS----------NYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSA 362

  Fly   397 TVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVML 461
            .||.||......:|.|.|:.||:|.|||||..|.....::..|||.|.:.|.|:.||||::|..|
Human   363 VVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFL 427

  Fly   462 PDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITY-LG 525
            |:........:..:.:..::.:|.|:|....|||||.:|..|:...|.:...|.|..||:.: |.
Human   428 PEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLA 492

  Fly   526 KDNLKLPLVIMGFL-SMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQFKDCCRCAQKPEILSQ 589
            ...|:|||:|.|.| |:.||:..| ||||....||:|:::.|:.|.    ...|:|.:..:   .
Human   493 AVWLELPLIIFGILASICGGLVML-LPETKGIALPETVDDVEKLGS----PHSCKCGRNKK---T 549

  Fly   590 PASYENL 596
            |.|..:|
Human   550 PVSRSHL 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	MFS_SLC22	152..551	CDD:340875	131/401 (33%)
		xylE	<306..>342	CDD:182225	20/35 (57%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	172/539 (32%)
		Proline-rich sequence. /evidence=ECO:0000305|PubMed:26979622	289..293		3/3 (100%)