Protein Alignment CarT and SLC22A1

DIOPT Version :10

• Sequence 1: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 160/522 - (30%)
• Similarity: 255/522 - (48%)
• Gaps: 45/522 - (8%)

  Fly    36 LDDLLPTIGEFGKYQKLLVFGICL------PACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPL 94
            :||:|..:||.|.:||.....:||      |.|:...|..|       |||.: |:.|.:.:  |
Human     4 VDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGF-------TPDHH-CQSPGVAE--L 58

  Fly    95 EQRKSLSIPKELD--------NDELVYSKCYTYGVNWTQLLESGEEDDLTTMEPNAS-WPLIKCP 150
            .||...|..:||:        ..|....:|..|.|:|.|...|. .|.|.::..|.| .||..|.
Human    59 SQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSC-VDPLASLATNRSHLPLGPCQ 122

  Fly   151 QGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTG---GPVGVYLFGLLNDRGGRRLSYF-V 211
            .||.|:|.  .||||.:|:|||.......:..:.||.|   |.:||   |...||.||:|... .
Human   123 DGWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGV---GYFADRFGRKLCLLGT 182

  Fly   212 CLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTS 276
            .|...::|.|| :.|.::.:....|::.||.....:...:.:..|.||...|..|.:|....:|.
Human   183 VLVNAVSGVLM-AFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTV 246

  Fly   277 GIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGR 341
            |::.|:|:.|....|..|....|||.:.:.||.:.:||||||||.:.|..||:||::.:|:.||:
Human   247 GLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGK 311

  Fly   342 EFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYG 406
            ..|        |.::...|::...:..:...|||.|||.:|.:|.::...||.:..:|.||..:.
Human   312 LPP--------ADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHM 368

  Fly   407 PALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLV 471
            .|...|.|:.|..||:||:|........:|..||.:|:::|.:|.|.||::.:.:..|.....::
Human   369 GATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNII 433

  Fly   472 LYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLK-LPLVI 535
            :..|.:..::.:..:|.....|||||.||.:|:...|.:..:|.|..|||.:..::..: |||::
Human   434 IMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLIL 498

  Fly   536 MG 537
            .|
Human   499 FG 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	MFS_SLC22	152..551	CDD:340875	121/391 (31%)
		xylE	<306..>342	CDD:182225	18/35 (51%)
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	156/512 (30%)