DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CarT and Slc22a4

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_071606.1	Gene:	Slc22a4 / 64037	RGDID:	621149	Length:	553	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	173/562 - (30%)
Similarity:	292/562 - (51%)	Gaps:	36/562 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPLEQRKS 99
            |.|:::..:|::|.:|:|:.| :...:.||.||...:.:|:|.|| ::.|.:|..::|....|..
  Rat     3 DYDEVIAFLGDWGPFQRLIFF-LLSASIIPNGFNGMSVVFLAGTP-EHRCLVPHTVNLSSAWRNH 65

  Fly   100 LSIPKELDNDELVYSKCYTYGV----NWTQL-LESGEEDDLTTMEPNASWPLIKCPQGWEYNTSV 159
             |||.|..:...|...|..|.:    |::.| ||.|.:.||..:|..:      |..||||:..|
  Rat    66 -SIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGLDVDLEQLEQES------CLDGWEYSKDV 123

  Fly   160 VWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLAGSLMTS 224
            ..|:||.:::|||:.|....:..:....|...|.::.|.|:||.||:...|..:|.....|.:..
  Rat   124 FLSTIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGFSFVQI 188

  Fly   225 LSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYR-SFVTVMTCTFYTSGIMLLSGVTYLE 288
            .|.::..:.....|||:...:.|.:.||:..|::.::.| .|.|:..|||:..|.|:|....|..
  Rat   189 FSTNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRILFSTLGVCTFFAIGYMVLPLFAYFI 253

  Fly   289 RDWVRLSYITSLP-FYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLE 352
            |||..|....:|| .:...|:.|: |||||||:.:.|.|||.:|:::.||:||...|..:...||
  Rat   254 RDWRMLLLALTLPGLFCVPLWWFI-PESPRWLISQRRFEEAEQIIQKAAKMNGIMAPAVIFDPLE 317

  Fly   353 AQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQYVSF 417
            .| ..:.||:||     |.:.||.:|.|:...|::..:.|......|..||...|.|..:.|::.
  Rat   318 LQ-ELNSLKQQK-----VFILDLFKTRNIATITVMSVMLWMLTSVGYFALSLNVPNLHGDVYLNC 376

  Fly   418 FLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALLSA 482
            |||.::|:|:|...|..:.|..||:.::..:..||...::..::|:|....::.|.::.|..:::
  Rat   377 FLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLVQVVPEDYNFVSIGLVMLGKFGVTS 441

  Fly   483 SFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTG 547
            :|.::|.|..|||||.||.:.:|.:|....:|.|..|:..|||..|..||.::||.|::|.|:..
  Rat   442 AFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVLIGIIT 506

  Fly   548 LRLPETLHHRLPQTIEEGEE---FGKNWQFKDCCRCAQKPEI 586
            |..||:....||:.:|:.::   |          ||.:|..:
  Rat   507 LFFPESFGVTLPENLEQMQKVRGF----------RCGKKSTV 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	166/523 (32%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	117/370 (32%)
Slc22a4	NP_071606.1	2A0119	12..519	CDD:273328	165/522 (32%)
Slc22a4	NP_071606.1	MFS	123..510	CDD:119392	125/393 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9198
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D375160at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.030