DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and SLC22A11

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_060954.1	Gene:	SLC22A11 / 55867	HGNCID:	18120	Length:	550	Species:	Homo sapiens

Alignment Length:	579	Identity:	147/579 - (25%)
Similarity:	247/579 - (42%)	Gaps:	107/579 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPLEQRKSLSIP 103
            ||...|..|.:|.|.|....|| |:                     .||..:   |.:..|.:||
Human     6 LLEQAGGVGLFQTLQVLTFILP-CL---------------------MIPSQM---LLENFSAAIP 45

  Fly   104 KELDNDELVYSKCYTYGVNWTQLLESGEEDDLTTMEPNA-----------------------SWP 145
            ..         :|      ||.:|::|.... |.|.|.|                       .|.
Human    46 GH---------RC------WTHMLDNGSAVS-TNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQ 94

  Fly   146 LI---------------KCPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYL 195
            |:               .|..||.|:.||..|:||..:||||.......:..:...:|..||.::
Human    95 LLDPNATATSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFI 159

  Fly   196 FGLLNDRGGRR--LSYFVCLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELV 258
            :|||:.|.||:  ||: .||...:||: .|..:..|..:.|.|.:....:..::.....:.:|..
Human   160 WGLLSYRFGRKPMLSW-CCLQLAVAGT-STIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWT 222

  Fly   259 GENYRSF-VTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMR 322
            ..:.|:. :||:.|.| ::|...|.|:.:..|||..|....|:||:|..|..:.:|||.|||:::
Human   223 TTSRRAVTMTVVGCAF-SAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIK 286

  Fly   323 GRLEEALKILERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANV----GLADLCRTPNMRL 383
            |:.::||:.|.::|::||.:  ||.:|.:|.     .:...|:::|:.    .:.||...|.:|.
Human   287 GKPDQALQELRKVARINGHK--EAKNLTIEV-----LMSSVKEEVASAKEPRSVLDLFCVPVLRW 344

  Fly   384 KTILITLSWFANETVYLGLSYYG-----PALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWP 443
            ::..:.:..|:     |.:||||     .:||.:.::...|...|:..........:...|||..
Human   345 RSCAMLVVNFS-----LLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTI 404

  Fly   444 LSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASS 508
            .:.|..:.|:|.:..:::|.|.....:|..::.|.....|...:..:..||:||.||....|...
Human   405 QAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILH 469

  Fly   509 YIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGL-RLPETLHHRLPQTIEEGE 566
            .:|.||.:..|.|....:....||.::.|.:|:...:..| .||||....||.||::.|
Human   470 TVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLE 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	142/567 (25%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	98/381 (26%)
SLC22A11	NP_060954.1	Sugar_tr	11..523	CDD:331684	142/567 (25%)
SLC22A11	NP_060954.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.020