Protein Alignment CarT and SLC22A15

DIOPT Version :9

• Sequence 1: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_060890.2
• Gene: SLC22A15 / 55356
• HGNCID: 20301
• Length: 547
• Species: Homo sapiens
• Alignment Length: 642
• Identity: 173/642 - (26%)
• Similarity: 264/642 - (41%)
• Gaps: 138/642 - (21%)

  Fly    30 VDEAFDLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMAD----------TPDDYWC 84
            |:|||.      .:||.|.||..|.|.:.:          ..||::|.          ||..:|
Human     3 VEEAFQ------AVGEMGIYQMYLCFLLAV----------LLQLYVATEAILIALVGATPSYHW- 50

  Fly    85 RIPELLDLPLEQRKSLSIPKELDNDELVYSKCYTYGVNWTQLLESGEEDDLTTMEPNASWPLIKC 149
               :|.:|         :|.:...::                 .:||:      :....|.|  .
Human    51 ---DLAEL---------LPNQSHGNQ-----------------SAGED------QAFGDWLL--T 78

  Fly   150 PQGWEYNTSVVWS----SIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYF 210
            ..|.|.:..|.:|    ||..::.|:.::....:...:...:|..|||..||.|:||.||:..|.
Human    79 ANGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYL 143

  Fly   211 VCLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYT 275
            ...|..:..::....|..:..:|.:|.:||:....:..:.|::..|.||..|.:....:...|:.
Human   144 TGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFA 208

  Fly   276 SGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNG 340
            .||...:.:.|..|.|..|:.:.:|.....||....:|||||||..:|||.||.:.|..:||
Human   209 VGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAK--- 270

  Fly   341 REFPEAVHLKLEAQIRRDKLK-------KQKKKMANVG-LADLCRTPNMRLKTILITLSWFANET 397
                           |..|||       ...:.....| ..||.|...:...|:::...||....
Human   271 ---------------RNRKLKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSL 320

  Fly   398 VYLGLSYYGPALGTNQYVSFFLSAVVELPSY-LCCWYFMDTW-GRRWPLSLSMILGGVACVITVM 460
            ||.||:.....||.:.|.:..||.::|:||| ||.:.....| ||:..||..:.|||:||:|.:.
Human   321 VYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMF 385

  Fly   461 LPDD------AVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIP 519
            ||:.      ||..:..|.|:.|..:||:|.|:|.:..|||||.:|.:|:|..|....:|.|..|
Human   386 LPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAP 450

  Fly   520 FITYLGKDNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEE---------GEEFGKNWQFK 575
            ||..|......||.::.|...:..|:..|.|||||:..|.:|..:         ||| ..:.|..
Human   451 FIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEE-ALSLQAL 514

  Fly   576 DCCRCAQKPEILSQPASYENLDVLAGSSTNASEVELELRDSRRVREPAPRIDERTPL 632
            |..:|..|...|             ||.   ||.|.|..|:          ||.|.:
Human   515 DPQQCVDKESSL-------------GSE---SEEEEEFYDA----------DEETQM 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	150/546 (27%)
		MFS	182..551	CDD:119392	117/384 (30%)
SLC22A15	NP_060890.2	MFS	111..469	CDD:119392	114/375 (30%)
		MFS_1	111..450	CDD:284993	108/356 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	522..547		12/50 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920