DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Orct2

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	174/587 - (29%)
Similarity:	299/587 - (50%)	Gaps:	42/587 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPLEQRKSLS 101
            |:.:..:|:||:|||::.|.|||.: ||..|.....:|:...| |:.|.      ||.|...|..
  Fly     4 DEAIIHLGDFGRYQKIIYFLICLTS-IPVAFHKLAGVFLLAKP-DFRCA------LPFENGSSYD 60

  Fly   102 IPKELDNDELVY---SKCYTYGVNWTQLLESGEEDDLTTMEPNASWPLIKCPQGWEYNTSVVWSS 163
            :|..|.|  |.|   .:|..|.|::|       |:.|....|.:|.....| ..:.|:.|...:|
  Fly    61 LPTHLWN--LSYPENERCSYYDVDYT-------EEYLNGSIPRSSNETKTC-SSYVYDRSKYLNS 115

  Fly   164 IVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLAGSLMTSLSKD 228
            .|.:::|||.:|.......:....|..:|..:||.|:|:.||:...|..|...:...::..::.:
  Fly   116 AVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPE 180

  Fly   229 FWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSGVTYLERDWVR 293
            ::|:..:|::||.|...|:.:.:::::|:||.:.|.:..:....|::.|.||.:...|...||..
  Fly   181 YFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRW 245

  Fly   294 LSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREF-PEAVHLKLEAQIRR 357
            |....:||...:..|.:::|||.||||::||.:.|:..:::.|:.|..|. .||:...|:.....
  Fly   246 LQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGENS 310

  Fly   358 DKLKKQKKKMANV------GLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQYVS 416
            ::..|||.:...:      .:.||...||:|.||:||.|.|.....||.|||:....||.|..::
  Fly   311 EEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLN 375

  Fly   417 FFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALLS 481
            |.:|..||:|:|:.....::.||||..|...:::.|::.:.||::|.......:...::.|..::
  Fly   376 FVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLAIT 440

  Fly   482 ASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMT 546
            ||:..:|.|:.|.:||.||.:.:||:|.:..:..:..||:.:|......|||:|.|.|:::.|:.
  Fly   441 ASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLL 505

  Fly   547 GLRLPETLHHRLPQTIEEGEEFGKNWQFKDCCRCAQK---PEILSQPASYENLDVLAGS-STNAS 607
            .|.||||.:..:.:||.:||.|||..:........|:   ||  :||        |.|| .||.|
  Fly   506 SLLLPETHNKPMLETIADGERFGKKTKADVYLETGQELRAPE--AQP--------LKGSGETNGS 560

  Fly   608 EV 609
            .:
  Fly   561 TI 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	155/526 (29%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	108/375 (29%)
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	155/526 (29%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	107/375 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1021
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm1022
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	7.960