DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CarT and slc22a2

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_998315.1	Gene:	slc22a2 / 406424	ZFINID:	ZDB-GENE-040426-2167	Length:	562	Species:	Danio rerio

Alignment Length:	578	Identity:	169/578 - (29%)
Similarity:	283/578 - (48%)	Gaps:	35/578 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDL------PLE 95
            :::|...|.||:.|..:....|| ..||..|.....:|...|| ::|||.|.:.::      .|:
Zfish     5 EEILEEAGTFGRSQIRIFCTFCL-VSIPFSFVYVGIVFQGFTP-EHWCRDPGVSEIRERCGWSLQ 67

  Fly    96 QRKSLSIPKELDNDELVYSKCYTYGVNWTQLLESGEEDD-------LTTMEPNASWPLIKCPQGW 153
            ..:..::|....:....||:|..:.|:|.....|.|..|       |:.|      |::.|..||
Zfish    68 DARRATVPLINGSSGASYSQCGRFDVDWNATGLSCENPDGDFNQSQLSVM------PMMSCVDGW 126

  Fly   154 EYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLA 218
            ||: .|...|.|.:|||||....|..:..|.|:.|..||....|.|.|:.||..|:.:....:..
Zfish   127 EYD-YVGRQSFVTEFDLVCGDAWYVDMFQATLSIGFLVGSIAIGYLADKYGRMKSFLMTNFFIGV 190

  Fly   219 GSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSG 283
            ..::.:.|.::.:....|.:.|..:...:.:.:::..||||.::|..|.|....|::.||:||..
Zfish   191 TGILVATSPNYISLLVFRALFGFGVKGGWMVGYVLITELVGVDHRRTVGVTYQLFFSMGILLLPL 255

  Fly   284 VTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVH 348
            :.|...:|..|..:.::|:..:..|.:.:||||||||.:.::.||::|.:.:||.|.:...:
Zfish   256 LAYFITNWRWLQVVFTVPYICFLTYYWFIPESPRWLLTQNKIAEAVEITKSIAKENRKTLSK--- 317

  Fly   349 LKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQ 413
             |:|. ::.|.:...    :.....||.:|..:|..|.:::.:||.:..||.||......||.|.
Zfish   318 -KIET-LKDDNIDSG----STASFMDLFKTAKLRTYTFILSFNWFTSAVVYQGLIMRLGILGGNV 376

  Fly   414 YVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKA 478
            ||.|.:|.:||||:.......::..|||.|.:.:.|:.|.||:||..:||........:..|.:.
Zfish   377 YVDFLISGIVELPAAFLILLTIERIGRRLPFATANIVAGAACLITAFIPDSMFWLKSAVACVGRL 441

  Fly   479 LLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITY-LGKDNLKLPLVIMGFLSML 542
            .::.:|.::.....|||||.:|.:|:...|.:..:|.|..||:.| |....|:|||:|.|.|:.:
Zfish   442 GITMAFEMVVFVNTELYPTVIRNLGVSVCSTLCDVGGIVAPFLLYRLAVIWLELPLIIFGALAFV 506

  Fly   543 GGMTGLRLPETLHHRLPQTIEEGEEFGKNWQFKDCCRCAQKPEILSQPASYENLDVLA 600
            .|...|.||||....||:||::.|...:|   |:..:.:|:.|.|......:|.||.|
Zfish   507 AGGLVLLLPETKGVPLPETIDDIEHPNRN---KENPQQSQQLENLMTSDVTKNKDVTA 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	156/530 (29%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	107/369 (29%)
slc22a2	NP_998315.1	2A0119	12..525	CDD:273328	156/530 (29%)
slc22a2	NP_998315.1	MFS	146..515	CDD:119392	108/377 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920