DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and SLC22A25

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	XP_016873173.1	Gene:	SLC22A25 / 387601	HGNCID:	32935	Length:	577	Species:	Homo sapiens

Alignment Length:	600	Identity:	147/600 - (24%)
Similarity:	242/600 - (40%)	Gaps:	104/600 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DLLPTIGEFGKYQKL-LVFGICLPACIPCGFCAFNQLFMADTP--------DDYWCRIPELLD-- 91
            |||..:|..|::|.| :||.|           .||.:....|.        .|:.|.: .:||
Human     5 DLLDQVGGLGRFQILQMVFLI-----------MFNVIVYHQTQLENFAAFILDHRCWV-HILDND 57

  Fly    92 -LP------LEQRKSLSIPKELDNDELVYSKCYTYGVNWTQLLESGEEDDLTTMEPNASWPLIK- 148
             :|      |.|...|.|....|:: |...||..:.....:|:.      |....||.|.|..:
Human    58 TIPDNDPGTLSQDALLRISIPFDSN-LRPEKCRRFVHPQWKLIH------LNGTFPNTSEPDTEP 115

  Fly   149 CPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRG---------- 203
            |..||.|:.|...|:||..:||||:.....::.......|..||..|:|.|:||.
Human   116 CVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRKPLSSPNHVST 180

  Fly   204 --------------------GR----RLSYF------VCLATLLAGSLMTSLSKDFWTWAGSRVI 238
                                ||    |.||.      .|.|  .|.:::...|..|...|.:..|
Human   181 DCDEGLEVPIAIHQHHVFWFGRKFVLRWSYLQLAIVGTCAA--FAPTILVYCSLRFLAGAATFSI 243

  Fly   239 VGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFY 303
            :..|:        ::.:|.:...:.:....:|....:.|.:.|..:.::.||...|..:.|.|.:
Human   244 IVNTV--------LLIVEWITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCF 300

  Fly   304 AYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEAQIRRDKLKK-----Q 363
            .:||:...:.||.|||::..:.||.||.|.:.|..||.:..|.:   |..::.:..:|:     |
Human   301 VFFLFSRWLAESARWLIINNKPEEGLKELRKAAHRNGMKNAEDI---LTMEVLKSTMKQELEAAQ 362

  Fly   364 KKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQYVSFFLSAVVELPSY 428
            ||.    .|.:|.|.||:..:...::...||:...:.||:.:...||.|.::...|...|.|.:.
Human   363 KKH----SLCELLRIPNICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLAN 423

  Fly   429 LCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALLSASFLIIYPFA-- 491
            ....:.::...||....|.|.|.....:..:.:|.:.  :||.:.|.:..:.:||..|....|
Human   424 CVAPWALNHMSRRLSQMLLMFLLATCLLAIIFVPQEM--QTLRVVLATLGVGAASLGITCSTAQE 486

  Fly   492 GELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGLRLPETLHH 556
            .||.|:.:||...|.:.....:|......:..|...:..||.:|.|..::|.|:..|.||||.:.
Human   487 NELIPSIIRGRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQ 551

  Fly   557 RLPQTIEEGEEFGKN 571
            .|..:|::.|..|.|
Human   552 PLLDSIQDVENEGVN 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	140/582 (24%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	94/415 (23%)
SLC22A25	XP_016873173.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010