DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Slc22a12

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	XP_038941497.1	Gene:	Slc22a12 / 365398	RGDID:	621628	Length:	578	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	163/581 - (28%)
Similarity:	258/581 - (44%)	Gaps:	85/581 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQL--FMADTPDDYWCRIPELLDLPLEQRKSL 100
            :||..:|..|::|.|....:..|.   ......|.|  |.|..| .:.|.:| |||....|   .
  Rat     5 ELLDRVGGRGRFQLLQAVALVTPI---LWVTTQNMLENFSAAVP-HHRCWVP-LLDNSTSQ---A 61

  Fly   101 SIPKELDNDELVY-----------SKCYTYGVNWTQLLESGEE----DDLTTMEPNASWPLIKCP 150
            |||.:...|.|:.           .:|..:.....||:||...    .|..| ||        |.
  Rat    62 SIPGDFGRDVLLAVSIPPGPDQRPHQCLRFRQPQWQLIESNTTATNWSDADT-EP--------CE 117

  Fly   151 QGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRR----LSYFV 211
            .||.|:.|...|:||..:|||||......:..:....|..||..:.|..:||.|||    .||.:
  Rat   118 DGWVYDHSTFRSTIVTTWDLVCDSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLL 182

  Fly   212 -----------------CL-----ATLLAGSLMTSLSKDFWTWAGSRVIVG----LTIPAVYQIP 250
                             ||     |:.:||.:|.:.|...:.     |::|    :..|.:....
  Rat   183 VSVSGTIAALMPTFPLYCLFRFLVASAVAGVMMNTASLCMFP-----VVLGREGYMQDPELTPSL 242

  Fly   251 FIISLELVGENYRSFVTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPES 315
            .:..:|.........:..:....::.|.:|...|.|..|.|..|....|.||:.:|:|.:.:|||
  Rat   243 LLAVMEWTSAQAGPLMMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPES 307

  Fly   316 PRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPN 380
            .|||:..|||:::|:.|:|:|.||.|: .||..|.:|. :|....::.....|...|..|..||.
  Rat   308 ARWLITVGRLDQSLRELQRVAAVNRRK-AEADTLTVEV-LRSAMQEEPNGNQAGARLGTLLHTPG 370

  Fly   381 MRLKTILITLSWFANETVYLGLSYYG-----PALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGR 440
            :||:|.:..|.|||     .|.::||     .|||:|.::...|..:|:||..:.....:...||
  Rat   371 LRLRTFISMLCWFA-----FGFTFYGLALDLQALGSNIFLLQALIGIVDLPVKMGSLLLLSRLGR 430

  Fly   441 RWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVR--GIG 503
            |...:.|::|.|:..:..:::|.:.......|.::....|.|:|..:..|:.||:||.:|  .:|
  Rat   431 RLCQASSLVLPGLCILANILVPREMGILRSSLAVLGLGSLGAAFTCVTIFSSELFPTVIRMTAVG 495

  Fly   504 IGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEE 564
            :|..:..|| .::| |.:..||.....|||::.|.:.:|.|:..|.||||.:..||.||::
  Rat   496 LGQVAARGG-AMLG-PLVRLLGVYGSWLPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQD 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	159/570 (28%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	110/405 (27%)
Slc22a12	XP_038941497.1	MFS_OAT	109..541	CDD:340932	127/454 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020